mu p75-SAP [IT-16, KIT-16]

a tool for eliminating cells that express p75NTR in mouse; targeted via NGFR affinity-purified rabbit polyclonal antibody, eliminated via saporin

SKU: IT-16 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Antibody Type: affinity-purified, Polyclonal | Host: Rabbit | Reactivity: Mouse | Conjugate: saporin | Usage: eliminates cells |

Conjugation of a low affinity nerve growth factor receptor (p75NTR) antibody to saporin has produced a cytotoxin that eliminates the CBF neurons, while sparing neighboring neurons that express GAD, calbindin and parvalbumin. mu p75-SAP eliminates cells expressing p75NTR in mouse. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

mu p75-SAP is a chemical conjugate of the affinity-purified rabbit polyclonal antibody p75NTR and the ribosome-inactivating protein, saporin. It specifically eliminates p75NTR-positive cells in mouse.

To eliminate p75NTR-expressing cells in rat, use 192-IgG-SAP (Cat. #IT-01). To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP (Cat. #IT-15).

mu p75-SAP is available individually (Cat. #IT-16) or as a kit (Cat. #KIT-16) which includes mu p75-SAP and Rabbit IgG-SAP (Cat. #IT-35).