ME20.4-SAP provides researchers with a powerful lesioning tool more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species, including rabbit and primate. Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75NTR)-positive cells in rabbit. Tissue-directed injection in primates causes loss of p75NTR-positive neurons. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.
ME20.4-SAP is a chemical conjugate of the p75NTR monoclonal antibody and the ribosome-inactivating protein, saporin. It specifically eliminates p75NTR-positive neurons in human, primate, rabbit, raccoon, dog, cat, pig and sheep.
keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, basal forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, ME20.4, p75, cholinergic forebrain neurons, Upper cervical ganglion, brain, neuroscience