ME20.4-SAP [IT-15, KIT-15]

a tool for eliminating cells that express p75NTR in multiple species; targeted via NGFR monoclonal antibody (ME20.4), eliminated via saporin

SKU: IT-15 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Antibody Type: Monoclonal | Host: mouse | Reactivity: cat, dog, human, pig, primate, rabbit, raccoon, sheep | Conjugate: saporin | Usage: eliminates cells, retrograde transport |

ME20.4-SAP provides researchers with a powerful lesioning tool more specific and effective than chemical, surgical or electrolytic lesioning and is active in several species, including rabbit and primate.  Intraventricular injection of ME20.4-SAP results in elimination of low affinity nerve growth factor receptor (p75NTR)-positive cells in rabbit.  Tissue-directed injection in primates causes loss of p75NTR-positive neurons.  Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

ME20.4-SAP is a chemical conjugate of the p75NTR monoclonal antibody and the ribosome-inactivating protein, saporin. It specifically eliminates p75NTR-positive neurons in human, primate, rabbit, raccoon, dog, cat, pig and sheep.

To eliminate p75NTR-expressing cells in mouse, use mu p75-SAP (Cat. #IT-16). To eliminate p75NTR-expressing cells in rat, use 192-IgG-SAP (Cat.#IT-01).

ME20.4-SAP is available individually (Cat. #IT-15) or as a kit (Cat. #KIT-15) which includes ME20.4-SAP and Mouse IgG-SAP (Cat. #IT-18).

keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, basal forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, ME20.4, p75, cholinergic forebrain neurons, Upper cervical ganglion, brain, neuroscience


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Mouse IgG-SAP (Cat. #IT-18)

NGFR Products:

NGFR (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43) | Cy3-labeled (Cat. #AB-N43-FL3) | Alexa488-labeled (Cat. #AB-N43-FLA)

NGFR (mu p75) Rabbit Polyclonal (Cat. #AB-N01) | affinity-purified (Cat. #AB-N01AP) | biotin-labeled (Cat. #AB-N01AP-BT) | Cy3-labeled (Cat. #AB-N01AP-FL3) | Cy5-labeled (Cat. #AB-N01AP-FL5) | Alexa488-labeled (Cat. #AB-N01AP-FLA)

NGFR (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) | biotin-labeled (Cat. #AB-N07-BT) | Alexa488-labeled (Cat. #AB-N07-FLA)

192-IgG-SAP (Cat. #IT-01)

mu p75-SAP (Cat. #IT-16)

ME20.4-SAP (Cat. #IT-15)

Targeting Tools: ME20.4 Monoclonal and Immunotoxin

Animal Models

A Brief History of Saporin and its Contributions to Neuroscience

Molecular Neurosurgery with Targeted Toxins 

NGFR Antibodies

Cytotoxicity Assay for Targeted Toxins in vitro

Concentration Calculation Explained: Convert molarity to mg/ml and mg/ml to molarity

Preparing and Interpreting Cytotoxicity Data in vitro

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