192-IgG is the antibody to the p75 neurotrophin receptor (p75NTR). The p75NTR, also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.
This fluorescent conjugate recognizes p75 receptor-positive cells in rat. It was prepared using mouse monoclonal antibody 192-IgG conjugated to Alexa 488. This product is routinely tested by flow cytometry.
Applications include flow cytometry, fluorescence spectroscopy, fluorescence anisotropy, epifluorescence microscopy, qualitative probe of binding to membrane-bound IgG’s and the cytoskeleton.
keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, basal forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, 192-IgG, p75, fluorescent, Alexa488