The low affinity nerve growth factor receptor (p75) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75 is expressed in various parts of the brain, notably in the basal forebrain by cholinergic neurons. Loss of these neurons is one of the hallmarks of Alzheimer’s disease.
This antibody recognizes the rat p75 low-affinity nerve growth factor receptor. The immunogen is isolated n-octoglucoside stabilized proteins containing p75 receptor from PC-12 cells. The antibody was produced in ascites fluid and purified by 50% (NH4)2SO4 precipitation followed by protein A column chromatography.
Applications include flow cytometry, immunohistochemistry, and targeting.
To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols