Targeted Toxins

Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery.

The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized).

The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface.

The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death.

Cells that do not have the cell surface marker are not affected.

192-IgG-SAP (Cat. #IT-01)cells that express p75NTR in rat
Acetylated LDL-SAP (Cat. #IT-08)cells that express microglia in primary cell cultures
Anti-6 His-SAP (Cat. #IT-52)cells with extracellular expression of 6 His-tagged proteins
Anti-CD103-SAP (Cat. #IT-50)cells that express CD103
Anti-CD105-SAP (Cat. #IT-80)cells that express human CD105 (Endoglin)
Anti-CD117-SAP (Cat. #IT-83)cells that express CD117 in mice
Anti-CD133-SAP (Cat. #IT-82)cells that express CD133 in human
Anti-CD22-SAP human (Cat. #IT-37)cells that possess the group-A epitope of the human B-cell antigen, CD22 in human
Anti-CD25-SAP human (Cat. #IT-24)cells that express Interleukin-2 (IL-2) receptor in human
Anti-CD25-SAP mouse (Cat. #IT-29)cells that express Interleukin-2 (IL-2) receptor in mouse
Anti-CD44-SAP (Cat. #IT-72)cells that express all isoforms of the CD44 receptor in multiple species
Anti-CD45.2-SAP (Cat. #IT-91)cells that express mouse CD45.2 in mouse
Anti-ChAT-SAP (Cat. #IT-42)cells that express choline acetyltransferase in multiple species
Anti-DAT-SAP (Cat. #IT-25)cells that express dopamine transporter (DAT-ECD) in rat or human
Anti-DBH-SAP (Cat. #IT-03)cells that express dopamine beta-hydroxylase in rat
Anti-FLAG (M5)-SAP (Cat. #IT-59)cells with extracellular expression of FLAG-tagged proteins
Anti-GFP-SAP (Cat. #IT-53)cells with extracellular expression of GFP-tagged proteins
Anti-PD-L1-SAP (Cat. #IT-45)cells that express human programmed death-ligand 1 (PD-L1)
Anti-SERT-SAP (Cat. #IT-23)cells that express serotonin re-uptake transporter
Anti-V5-SAP (Cat. #IT-58)cells with extracellular expression of V5-tagged proteins
Anti-vGAT-SAP (Cat. #IT-71)cells that express express the vesicular GABA transporter
Anti-YFP-SAP (Cat. #IT-66)cells with extracellular expression of YFP and EYFP-tagged proteins
Bombesin-SAP (Cat. #IT-40)cells that express gastrin releasing peptide (GRP) receptor
CCK-SAP (Cat. #IT-31)cells that express CCK Receptor
Chlorotoxin-SAP (Cat. #IT-86)cells that express MMP-2 isoforms
CRF-SAP (Cat. #IT-13)cells that express the corticotropin-releasing factor (hormone) receptor 1
CTB-SAP (Cat. #IT-14)cells that express the GM1 receptor
Dermorphin-SAP / MOR-SAP (Cat. #IT-12)cells that express the mu-opioid receptor (MOR)
Dyno-SAP (Dynorphin-SAP) (Cat. #IT-68)cells that express kappa-opioid receptor
Ex4-SAP (GLP-1-SAP) (Cat. #IT-90)cells that express GLP-1R
FGF-SAP (Cat. #IT-38)cells that express FGF receptor
Galanin-SAP (Cat. #IT-34)cells that express galanin-1 receptor
GAT1-SAP (Cat. #IT-32)cells that express GABA-1 transporter in mutiple species
Hemokinin 1-SAP (Cat. #IT-76)cells that express neurokinin-1 (NK-1) receptor
IB4-SAP (Cat. #IT-10)cells that express α-D-galactopyranoside residues
Leptin-SAP (Cat. #IT-47)cells that express leptin receptor
Mac-1-SAP mouse/human (Cat. #IT-06)cells that express Mac-1 (CD11b) receptor in mouse or human
ME20.4-SAP (Cat. #IT-15)cells that express p75NTR in multiple species
Melanopsin-SAP (Cat. #IT-44)cells that express melanopsin in mouse intrinsically photosensitive retinal ganglion cells
MOA-SAP (Cat. #IT-92)cells that express specific galactose residues
mu p75-SAP (Cat. #IT-16)cells that express p75NTR in mouse
Neurotensin-SAP (Cat. #IT-56)cells that express neurotensin receptor
NKB-SAP (Cat. #IT-63)cells that express NK3 (NKB receptor)
NMB-SAP (Cat. #IT-70)cells that express Neuromedin B receptor
Nppb-SAP (Cat. #IT-69)cells that express Neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor
NPY-SAP (Cat. #IT-28)cells that express the Neuropeptide Y (NPY)
Orexin-B-SAP (Cat. #IT-20)cells that express the orexin-2 receptor
Oxytocin-SAP (Cat. #IT-46)cells that express oxytocin receptor
PACAP-SAP (Cat. #IT-84)cells that express VPAC1, VPAC2, or PAC1 receptors
SSP-SAP (Cat. #IT-11)cells that express substance P receptor (NK-1)

View a complete listing here.

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