Anti-CD63-SAP [IT-99, KIT-99]

Name: Anti-CD63-SAP [IT-99, KIT-99]
SKU: IT-99
Availability: InStock

a tool for eliminating cells that express human CD63; targeted via a mouse monoclonal antibody to human CD63, eliminated via saporin

Size

Clear

First time ordering this product? Consider purchasing a kit which also includes controls.

SKU: IT-99 Category: Targeted Toxins Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Antibody Type: Monoclonal | Host: mouse | Reactivity: human | Conjugate: saporin | Usage: eliminates cells |

CD63 is a protein that is expressed on the surface of various cell types, including certain immune cells (such as T-cells, B-cells, and macrophages), and tumor cells. CD63 is a member of the tetraspanin family of proteins, which are involved in processes like cell adhesion, endocytosis, signal transduction, and the formation of exosomes.

This targeted toxin recognizes cells that express human CD63. Anti-CD63-SAP is a chemical conjugate of the antibody to CD63 and the ribosome-inactivating protein, saporin.

Anti-CD63-SAP is available individually (Cat. #IT-99) or as a kit (Cat. #KIT-99) which includes Anti-CD63-SAP and Mouse IgG-SAP (Cat. #IT-18).

keywords: CD63, immune cells, T-cell, B-cell, macrophage, tumor, tetraspanin, adhesion, endocytosis, signal transduction, exosomes, saporin, targeted toxin

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View Data Sheet

Identification of lineage-specific markers for therapeutic targeting of mast cells.

Plum T (2019) Identification of lineage-specific markers for therapeutic targeting of mast cells. Ruperto-Carola University of Heidelberg, Germany Thesis. doi: 10.11588/heidok.00023555

Usage: Mice were injected i.v. with either 100 µg of 1:1 molar mixture of biotinylated CD63 antibody and Streptavidin-ZAP (60 µg mAb + 40 µg SAP) or with 40 µg SAP alone. All injections were performed in 200 µl PBS.

Related Products: Streptavidin-ZAP (Cat. #IT-27), Saporin (Cat. #PR-01), Anti-CD63-SAP (Cat. #IT-99)