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TOOLS FOR SELECTIVELY ALTERING CELLS
BASED ON CELL-SURFACE MARKERS
A TARGETING AGENT IS CONJUGATED TO A PAYLOAD. HERE THE CONJUGATE IS AN ANTIBODY LINKED TO A SMALL MOLECULE
THE TARGETED CONJUGATE BINDS ONLY THE CELLS THAT ARE SPECIFIC TO THE ANTIBODY CAUSING THE RECEPTOR TO INTERNALIZE
THE INTERNALIZED CONJUGATE IS DIGESTED BY ENZYMES RELEASING THE PAYLOAD INTO THE CYTOSOL. THE PAYLOAD IS THEN FREE TO ALTER THE CELL.
