The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.
This antibody recognizes the p75NTR (low affinity neurotrophin receptor) in human, primate, rabbit, sheep, dog, cat, and pig. It was derived from immunization of mice with WM245 melanoma cells. It has been conjugated to biotin via an amide bond. The antibody is routinely tested by flow cytometry.
Applications include flow cytometry, immunoprecipitation, immunohistochemistry, electron microscopy, immunocytochemistry, and radioimmunoassay.
keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, basal forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, ME20.4, p75, biotin, brain, neuroscience