The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.
This antibody recognizes the p75NTR in mouse. The antisera was developed in rabbit using an extracellular fragment from the mouse p75 receptor (amino acids 43-161). The antibody is routinely tested by flow cytometry.
Applications include immunohistochemistry, immunoprecipitation, immunoblotting, flow cytometry, and blocking the function of nerve growth factor receptor.
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