Tools to study Programmed Cell Death

Antibodies you can rely on.

The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo apoptosis.

Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. Donnelly CR, Gabreski NA, Suh EB, Chowdhury M, & Pierchala BA. (2018) J Cell Biol Biol, 217 (9):327.

Cat. #AB-N01 Anti-p75

Dose:  Proximity ligation assays (1:500); Western blotting (1:1,000)

NIH/3T3 cells were transfected as indicated (Ret51 and p75 [left] or HA-tagged Ret51 and p75 [right], with higher magnification panels displayed on bottom), followed by brief fixation. DuoLink proximity ligation assays were performed using Anti-p75 (Cat. #AB-N01) and Anti-HA primary antibodies. Red staining indicates colocalization pattern observed in 3T3 cells transfected with HA-Ret51 and p75 compared with Ret51 and p75-transfected 3T3 cells. Bar, 20 μm.
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