Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. When there are disruptions in the signals between the lowest motor neurons and the muscle, the muscles do not work properly; the muscles gradually weaken and […]
Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for […]
Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide […]
TARGETED TOXINS – Targeting agent attached to Saporin IT-01 192-IgG-SAPNeuropharmacology of attention. Burk JA, et al. Eur J Pharmacol 835: 162-168, 2018 Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Cho JS, et al. Yonsei Med J 59: (3):406-415, 2018.Intracerebroventricular Administration of […]
Nilupaer Abudukeyoumu! Her poster was presented at the 2018 Society for Neuroscience meeting that was held in San Diego, CA: Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons Authors on the winning poster are pictured below L. to R.: Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, and Gordon W. Arbuthnott. Nilupaer Abudukeyoumu is a […]
by Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, Gordon W. Arbuthnott.Brain Mechanism for Behavior Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan Cholinergic interneurons (ChIs) are sparsely distributed within the striatum, a nucleus that plays important roles in voluntary motor control, associated learning, procedural memory, execution of movement, action selection, and planning.[1] ChIs […]
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In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.1 Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.2 The figure below illustrates the specificity […]
Cat. #IT-69 Nppb-SAP Meng, Qing-Tao and Liu, Xian-Yu and Liu, Xue-Ting and Barry, Devin M. and Jin, Hua and Yang, Qianyi and Sun, Yu and Wan, Li and Jin, Jin-Hua and Munanairi, Admire and Kim, Ray and Yin, Jun and Tao, Ailin and Chen, Zhou-Feng, Cross-Talk between Distinct Receptors Shapes Itch Behavior in the Spinal […]