Author name: Kristen Hartman

Saporin-produced Temporal Lobe Epilepsy Animal Model

Developing reliable animal models can be time-consuming, complex, and difficult to control. Our saporin-based approach enables targeted elimination of specific cell populations, allowing you to create precise animal models for studying disease, behavior, and biological function—without the long timelines of traditional methods. This approach has been widely used to generate models for neurological and disease-specific research, where selective […]

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Antimetabolites synergize with antibody drug conjugate-based non-genotoxic conditioning facilitating hematopoietic stem cell-directed lentiviral gene therapy

Okalova J, Alexander JS, Patel SR, Branella GM, Barichello de Quevedo C, Baldwin WH, Prince C, Chandrakasan S, Brown HC, Doering CB, Spencer HT (2026) Antimetabolites synergize with antibody drug conjugate-based non-genotoxic conditioning facilitating hematopoietic stem cell-directed lentiviral gene therapy. Mol Ther Adv doi: 10.1016/j.omta.2026.201780 Objective: To investigate the hypothesis that anti-CD117-sap is not effective

Antimetabolites synergize with antibody drug conjugate-based non-genotoxic conditioning facilitating hematopoietic stem cell-directed lentiviral gene therapy Read More »

The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling

Tierno Lauer L, Hayes AMR, Suarez AN, Bashaw A, Klug ME, Kao AE, Cheng R, Rea JJ, Subramanian KS, Nourbash A, Donohue KN, Schier LA, Myers K, Décarie-Spain L, Kanoski SE (2026) The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling. Nat Commun doi: 10.1038/s41467-026-73896-2 PMID: 42236727 Objective: To demonstrate that nutrient

The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling Read More »

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P-saporin

Gupta S, Kesler MT, Scantlebury MH, Sloviter RS, Teskey GC (2026) Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P-saporin. Epilepsia doi: 10.1002/epi.70322 PMID: 42220243 Objective: To determine the time course of SSP-­SAP-­induced epileptogenesis, as well as the loss of principal cells and astrogliosis, two defining features of

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P-saporin Read More »

Cerebrospinal fluid-contacting nucleus mediates the balance of depth during general anesthesia in mice

Zhang YW, Jia WX, Wang YQ, Zhou P, Zhang XY, Liu CW, Wang J, Lu XF, Dai CF (2026) Cerebrospinal fluid-contacting nucleus mediates the balance of depth during general anesthesia in mice. Neuropharmacology 111037. doi: 10.1016/j.neuropharm.2026.111037 PMID: 42214455 Objective: To investigate the role of the cerebrospinal fluid-contacting nucleus (CSF-CN), which directly interfaces with the CSF,

Cerebrospinal fluid-contacting nucleus mediates the balance of depth during general anesthesia in mice Read More »

Overexpression of WNT3a in the hippocampus can partly alleviate deficits in animal models of Alzheimer’s Disease

Gerasimov KA, Ignasheva YE, Dobryakova YV, Korotkova TA, Koryagina AA, Markevich VA, Bolshakov AP (2026) Overexpression of WNT3a in the hippocampus can partly alleviate deficits in animal models of Alzheimer’s Disease. Neurochem Res 51(3):174. doi: 10.1007/s11064-026-04793-9 PMID: 42185674 Objective: To investigate whether enhancing WNT signaling through hippocampal overexpression of the WNT3a ligand can mitigate functional

Overexpression of WNT3a in the hippocampus can partly alleviate deficits in animal models of Alzheimer’s Disease Read More »

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets

Voisin T, Gheziel N, El Samrout C, Martin J, Bradaia A, Iftinca M, Defaye M, Charron A, Abdullah NS, Changenot C, Gonzalez AA, Depluech A, Labit E, Saint-Laurent N, Staurengo-Ferrari L, Erdogan O, Tauber M, Loste A, Serhan N, Villa-Hernandez S, Chiu IM, Moqrich A, Altier C, Basso L, Gaudenzio N (2026) Skin inflammation and

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets Read More »

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