Kristen

A Brief History of Saporin and its Contributions to Neuroscience

ABSTRACT When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to unique extracellular target), and appropriate place to begin is with the Nobel Prize-winning work of Paul Ehrlich and his concept of the “magic bullet.” Over 100 years later, the use of targeted toxins to perform molecular neurosurgery has become …

A Brief History of Saporin and its Contributions to Neuroscience Read More »

FENS 2022

Join us at Europe’s largest international neuroscience conference, covering all domains in modern brain research from basic to translational research Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 48, July 10-13 …

FENS 2022 Read More »

EACR 2022

EACR 2022 Congress – Innovative Cancer Science: Translating Biology to Medicine 20-23 June 2022, Seville, Spain Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 12, June 20-23 and find out how …

EACR 2022 Read More »

Mab-ZAP binds to Fc portion of mouse IgG

Q: Does Mab-ZAP (Cat. #IT-04) bind to the FC portion of mouse IgG? A: The antibody used to create our Mab-ZAP (IT-04), will react with whole molecule mouse IgG, which includes the Fc portion and the two antigen binding Fab portions. Related Products: ZAP Conjugates

Worked to the bone: antibody-based conditioning as the future of transplant biology

Griffin JM, Healy FM, Dahal LN, Floisand Y, Woolley JF (2022) Worked to the bone: antibody-based conditioning as the future of transplant biology. J Hematol Oncol 15(1):65. doi: 10.1186/s13045-022-01284-6 Objective: To analyze the current status of antibody-based drugs in pre-transplant conditioning regimens and assess their potential in the future of transplant biology. Summary: This review …

Worked to the bone: antibody-based conditioning as the future of transplant biology Read More »

Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior

Krieger JP, Asker M, Van der Velden P, Börchers S, Richard JE, Maric I, Longo F, Singh A, De Larigue G, Skibicka KP (2022) Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior. Biological Psychiatry in press. doi: 10.1016/j.biopsych.2022.04.020 Objective: To determine how the sensing …

Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior Read More »

Immunology 2022

Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 339 May 7-9 and find out how you can use Molecular Surgery to accelerate your Immunology research!

Targeting Trends 2021 Review

Read the complete 2021 Review. Targeted Ablation with IB4-SAP: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Scientific References Top 20 Targeting Tools