Archive by Author

Targeting Glioblastoma

Glioblastoma, or glioblastoma multiforme (GBM), is a rare disease, with a global incidence of <10 per 100,000 people; the prognosis is very poor.  Here are a couple of recent studies testing targeted saporin therapies. Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Munksgaard Thorén M, Chmielarska Masoumi K, Krona C, […]

Q1 2019 Scientific Review

IT-01: 192-IgG-SAP     • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print]  Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with […]

Targeting motor neuron disease

Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. When there are disruptions in the signals between the lowest motor neurons and the muscle, the muscles do not work properly; the muscles gradually weaken and […]

Call for Proposals

Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for […]

Targeting Tools: Top Twenty of 2018

Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide […]

Targeting Topics: 2018 Scientific References

TARGETED TOXINS – Targeting agent attached to Saporin IT-01 192-IgG-SAPNeuropharmacology of attention. Burk JA, et al. Eur J Pharmacol 835: 162-168, 2018 Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Cho JS, et al. Yonsei Med J 59: (3):406-415, 2018.Intracerebroventricular Administration of […]

The 2018 Poster of the Year Award Goes To . . .

Nilupaer Abudukeyoumu! Her poster was presented at the 2018 Society for Neuroscience meeting that was held in San Diego, CA: Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons Authors on the winning poster are pictured below L. to R.: Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, and Gordon W. Arbuthnott. Nilupaer Abudukeyoumu is a […]

Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons

by Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, Gordon W. Arbuthnott.Brain Mechanism for Behavior Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan Cholinergic interneurons (ChIs) are sparsely distributed within the striatum, a nucleus that plays important roles in voluntary motor control, associated learning, procedural memory, execution of movement, action selection, and planning.[1] ChIs […]

Targeting Trends 2018 Review

Below are links to view the 2018 annual review newsletter Targeting Trends. You can also download the full PDF here. If you would like to be added to the mailing list, please subscribe here.