Kristen Hartman

Streptavidin-saporin: Converting biotinylated materials into targeted toxins

This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and research performed using Streptavidin-ZAP and its impact on academia and industry for research and drug development are presented. Read the full article as …

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Streptavidin-saporin: Converting biotinylated materials into targeted toxins

Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2023) Streptavidin-saporin: Converting biotinylated materials into targeted toxins. Toxins 15(3):181. doi: 10.3390/toxins15030181 Summary: This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and …

Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »

Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility

Bolaina-Lorenzo E, Martínez-Ramos C, Monleón-Pradas M, Herrera-Kao W, Cauich-Rodríguez JV, Cervantes-Uc JM (2016) Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility. Biomed Mater 12(1):015008. doi: 10.1088/1748-605x/12/1/015008 PMID: 27934786 Objective: To study the effect of scaffold compositions on its physicochemical and biological properties. Summary: Immunochemistry analysis with p75 analysis confirmed that …

Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility Read More »

Equimolar mixing of Streptavidin-ZAP and Biotinylated Molecule

Question: I was wondering if you could elaborate on why the Streptavidin-ZAP product recommends to be used at an equimolar ratio with the targeting reagent, when it is capable of binding up to four biotins/molecule? Answer: It’s a question we get asked sometimes and it’s a good question. You are correct that streptavidin is capable …

Equimolar mixing of Streptavidin-ZAP and Biotinylated Molecule Read More »

Which type of RIP is saporin?

Q: I read on your website that, “There are two types of RIPs: type I, which are much less cytotoxic due to the lack of the B chain and type II, which are distinguished from type I RIPs by the presence of the B chain and their ability to enter cells on their own.” In …

Which type of RIP is saporin? Read More »

Latest Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP

Happy New Year! Check out the latest Saporin publication. Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060. We would be pleased to send you our …

Latest Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP Read More »

Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease

Leanza G, Zorec R (2023) Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease. Function (Oxf) 4(1):zqac060., IT. doi: 10.1093/function/zqac060 PMID: 36590326 Summary: These results indicate a prominent role of NA-neurons vs. ACh neurons in impairments of working memory, relevant for AD, and are consistent with an astrocyte-specific metabolic impairment in a mouse model of intellectual disability. …

Towards astroglia-based noradrenergic hypothesis of Alzheimer’s disease Read More »

2023 Calendars

We would be pleased to send you our 2023 ATS calendar. Please choose your options and provide us with a shipping address to send your calendar. Happy Holidays! Renaissance Wall Calendar Knockout Mouse 12-month Desktop Calendar Or please complete this form and indicate which calendar you prefer (or both)! Happy Holidays!

Happy Holidays and 2023 Calendars

Thank you for the amazing scientific data you have published in 2022. We appreciate your creativity and ingenuity using the Saporin targeting technology. We would be pleased to send you our 2023 ATS calendar. Click here to provide us your shipping address to send your calendar.

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190 Objective: To use a new murine testing model …

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells Read More »