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Noradrenaline production reduced after treatment with Anti-DBH-SAP

Changes in the Secretory Activity of Organs Producing Noradrenaline Upon Inhibition of Its Synthesis in Neonatal Rat Brain. Murtazina, AR, Dilmukhametova, LK, Nikishina, YO, Sapronova, AY, Volina, EV, & Ugrumov, MV. (2017). Russian Journal of Developmental Biology, 48 (5):295-300. This study demonstrates that synthesis of noradrenaline after destruction of noradrenergic neurons was switched off by stereotactically […]

Neuroscientists in Spain report work with 192-IgG-SAP

Two posters using ATS products are being presented this week at SENC (17 Congreso Nacional de Sociedad Española de Neurociencia). LEARNING AND MEMORY IMPAIRMENT IN RATS WITH CHOLINERGIC BASAL FOREBRAIN LESION IS RELATED TO CB1 CANNABINNOID RECEPTORS UP REGULATION  Moreno-Rodríguez M., Villanueva D., Martínez-Gardeazabal J., Llorente-Ovejero A., Manuel I., Rodríguez-Puertas R. Department of Pharmacology, Faculty […]

Visualizing Retinal Ganglion Cells with Anti-Melanopsin

3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths. Bray, ER, Noga, M, Thakor, K, et al. (2017). eNeuro DOI “Our study demonstrates extensive and circuitous RGC axon elongation both in pre- and post-lesion regions, highlighting the need to better understand the factors that inhibit direct axon growth in the […]

Got an itch? Bombesin-SAP may help

Itch Induces Conditioned Place Aversion in Mice. Mu, D, & Sun, Y-G. (2017). Neuroscience Letters, http://dx.doi.org/10.1016/j.neulet.2017.08.046 “Consistently, ablation of itch‐specific neurons that express gastrin‐releasing peptide receptor in the spinal cord also abolished itch‐induced Conditioned Place Aversion (CPA), confirming that itch‐induced CPA is dependent on the spinal itch circuit.” Mice were given a single intrathecal injection […]

Cholera Toxin B-Saporin: A targeting tool to study ALS

Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death. Nichols NL, Craig TA, & Tanner MA. (2017) Respiratory Physiology & Neurobiology. Available online 16 August 2017. In Press, Corrected Proof. There are currently no approved treatment options to significantly preserve/restore breathing capacity in patients with Amyotrophic lateral sclerosis (ALS). Intrapleural CTB-SAP (Cat. #IT-14) mimics […]

Parkinson’s Disease, Unsteady Gait, and the ChAT Walk

Selective Cholinergic Depletion of Pedunculopontine Tegmental Nucleus Aggravates Freezing of Gait in Parkinsonian Rats.  Xiao, H, Li, M, Cai, J, et al. (2017). Neurosci Lett [Epub 10 August 2017]. PMID: 28803956 Many patients with advanced Parkinson’s disease suffer from gait and postural impairments.  The authors used Anti-ChAT-SAP (Cat. #IT-42) to specifically lesion neurons in the Pedunculopontine Tegmental Nucleus (PPTg) to examine the […]

Blocking Microglial Channels: Mac-1-SAP as a Targeting Tool

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.  Burma, N.E., R.P. Bonin, H. Leduc-Pessah, et al.  Nat Med, 2017. 23(3): p. 355-360. PMID: 28134928 The authors investigated the mechanisms underlying opiate withdrawal in rat.  Depletion of spinal lumbar microglia by intrathecal injections of Mac-1–SAP (Cat. #IT-33; 20 mcg) decreased withdrawal behaviors and attenuated the severity of […]

MOR-expressing neurons in Pain, Addiction and Mast Cell Function

The rostromedial tegmental nucleus and alcohol addiction. Ye J-H, Fu R, He W. (2017). Impact Journals. 2017;8(12):18624-18625. The authors discuss their work (1) with Dermorphin-SAP (Cat. #IT-12) and their demonstration that damage of RMTg MOR-expressing GABAergic neurons by Dermorphin-SAP increased the intake and preference for alcohol, boosted the expression and slowed down the extinction of alcohol […]

192-IgG-SAP and the Sleep Regulatory System

Acute Effects of Alcohol on Sleep Are Mediated by Components of Homeostatic Sleep Regulatory System: An Editorial Highlight for ‘Lesions of the Basal Forebrain Cholinergic Neurons Attenuates Sleepiness and Adenosine after Alcohol Consumption.’ Alam, MN, & McGinty, D. (2017). J Neurochem 2017/07/25. In the study, titled ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and […]

CCK-SAP: a novel selective vagal deafferentation technique

Validation and Characterization of a Novel Method for Selective Vagal Deafferentation of the Gut. Diepenbroek C, Quinn D, Stephens R, Zollinger B, Anderson S, Pan A, de Lartigue G. Am J Physiol Gastrointest Liver Physiol 2017. PMID: 28705805 The authors Injected CCK-SAP (Cat. #IT-31) into the nodose ganglia (NG) of rats to specifically ablate GI‐VAN […]