Disease Treatment without the current toxicities
episode16, episode40
Disease Treatment without the current toxicities Read More »
Photochemical enhancement of PD-L1-SAP immunotoxin efficacy in non-small cell lung cancer cell lines
Kozlíková M, Aukrust IKF, Rohlíčková M, Macháček M, Berg K, Weyergang A, Selbo PK (2026) Photochemical enhancement of PD-L1-SAP immunotoxin efficacy in non-small cell lung cancer cell lines. Front Immunol 17:1750003. doi: 10.3389/fimmu.2026.1750003 PMID: 41909645 Objective: To investigate photochemical internalization (PCI), a light–controlled endosomal escape technology, as a strategy to enhance intracellular delivery and efficacy
Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis
Lim-Paik C, Zeng Q, Beyea R, Boohaker R, Wang P (2026) Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis. Biomedicines 14(3):626. doi: 10.3390/biomedicines14030626 Objective: To identify structurally defined novel natural saponins and evaluate their ability to enhance anticancer cytotoxicity. Summary: Saponins have recently emerged as promising natural products that
40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway
Chen J, Xu T, Zhang C, Li L, He Y, Sun Z, He J, Yao Z, Cai P, Huang Y, Ye F, Guo W, Jia M, Qu J, Chen JF, Zhang Y (2026) 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway. Cell Res doi: 10.1038/s41422-026-01227-7 PMID: 41781500 Objective: To
uPAR-targeting cytotoxic antibody–drug conjugates selectively deplete proinflammatory myeloid cells for autoimmune indications
Xiang H, Mortenson GP, Lang SB, Jakkaraju S, Chirala A, Zhu Y, Jia M, Wen J, Chen Y, Baghela A, Chen YC, Sze MA, Hegde LG, Zhang-Hoover J, Willingham A, Handa M, Chi A, Baltus GA, Kamath RV, Levesque M, Vollmann EH (2026) uPAR-targeting cytotoxic antibody–drug conjugates selectively deplete proinflammatory myeloid cells for autoimmune indications.
Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice
Hamakubo S, Komatsu N, Kosai A, Kuroda M, Sawada M, Shimizu R, Ohashi R, Suenaga H, Hamakubo T, Abe T (2026) Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice. Biomedicines 14:573. doi: 10.3390/biomedicines14030573 Objective: To investigate the in vivo therapeutic efficacy of intelligent Targeted Antibody Phototherapy (iTAP), utilizing
Eliminating CD150-expressing HSCs
episode10, episode34
Eliminating CD150-expressing HSCs Read More »