Author name: Kristen Hartman

Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis

Lim-Paik C, Zeng Q, Beyea R, Boohaker R, Wang P (2026) Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis. Biomedicines 14(3):626. doi: 10.3390/biomedicines14030626 Objective: To identify structurally defined novel natural saponins and evaluate their ability to enhance anticancer cytotoxicity. Summary: Saponins have recently emerged as promising natural products that […]

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Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice

Hamakubo S, Komatsu N, Kosai A, Kuroda M, Sawada M, Shimizu R, Ohashi R, Suenaga H, Hamakubo T, Abe T (2026) Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice. Biomedicines 14:573. doi: 10.3390/biomedicines14030573 Objective: To investigate the in vivo therapeutic efficacy of intelligent Targeted Antibody Phototherapy (iTAP), utilizing

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PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway

Wang W, Zhang Y, Li L, Xu Y, Zhang W, Chen X, Wang X, Tong G, Zhang P (2026) PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway. Biochem Biophys Res Commun 808:153462. doi: 10.1016/j.bbrc.2026.153462 PMID: 41702189 Objective: To investigate the mechanism of PACAP in ipRGC–VLPO light-induced sleep. Summary: Partial ablation of ipRGCs by Melanopsin-SAP

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An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins

Yang Y, Jia H, Yang L, He B, Zhang K, Liu H (2026) An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins. Int J Nanomedicine 21:1-14. doi: 10.2147/IJN.S557672 Summary: The authors report a novel AIEgen (Aggregation-induced emission luminogen) -based carrier, MTPABP-Guided-Intracellular-Carrier (MAGIC), that achieves high efficiency in delivering native proteins into the cytosol. MAGIC

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