Author name: Kristen Hartman

Modulation of orexinergic neurons in the perifornical region of the hypothalamus impacts tongue motility and hypoglossal motor output in an inducible rodent model of hypoglossal motor neuron degeneration

Keilholz A, Ahmadzadeh E, Cornelius-Green J, Osman K, Smith C, Cummings K, Lever T, Nichols N (2026) Modulation of orexinergic neurons in the perifornical region of the hypothalamus impacts tongue motility and hypoglossal motor output in an inducible rodent model of hypoglossal motor neuron degeneration. American Physiology Summit 41(S1) doi: 10.1152/physiol.2026.41.S1.2300706 Objective: To examine role […]

Modulation of orexinergic neurons in the perifornical region of the hypothalamus impacts tongue motility and hypoglossal motor output in an inducible rodent model of hypoglossal motor neuron degeneration Read More »

Impact of targeted tongue exercise on genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death

Burd E, Keilholz A, Attari M, Smith C, Bunyak F, Lever T, Nichols N (2026) Impact of targeted tongue exercise on genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death. American Physiology Summit 41(S1) doi: 10.1152/physiol.2026.41.S1.2301276 Objective: To establish a rodent model for studying the impact of XII LMN degeneration

Impact of targeted tongue exercise on genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death Read More »

Impact of tongue exercise on hypoglossal nucleus TrkB expression in a rodent model of hypoglossal motor neuron degeneration

Miller J, Keilholz A, Smith C, Lever T, Nichols N (2026) Impact of tongue exercise on hypoglossal nucleus TrkB expression in a rodent model of hypoglossal motor neuron degeneration. American Physiology Summit 41(S1) doi: 10.1152/physiol.2026.41.S1.2300331 Objective: To investigate treatments to improve upper airway function primarily due to loss of hypoglossal lower motor neurons (XII LMNs)

Impact of tongue exercise on hypoglossal nucleus TrkB expression in a rodent model of hypoglossal motor neuron degeneration Read More »

Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration

Keilholz AN, Lopez S, Attari M, Nguyen NP, Henry J, Smith CL, Feldberg A, Osman KL, Golzy M, Bunyak F, Lever TE, Nichols NL (2026) Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration. J Neurophysiol doi: 10.1152/jn.00631.2024 PMID: 42012472 Objective: To investigate the

Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration Read More »

Visualization of endosomal escape of intracellularly delivered protein with unexpected photochemical internalization of trypan blue

Yao Z, Shi Z, Hu P, Wang C, Wang H (2026) Visualization of endosomal escape of intracellularly delivered protein with unexpected photochemical internalization of trypan blue. Adv Sci (Weinh) e16456. doi: 10.1002/advs.202516456 PMID: 41961480 Objective: To demonstrate trypan blue as a simple yet powerful tool for advancing intracellular protein delivery and tracking. Summary: Upon 590

Visualization of endosomal escape of intracellularly delivered protein with unexpected photochemical internalization of trypan blue Read More »

In utero HSC transplantation for sickle cell disease: A potential therapeutic approach that overcomes complications of current therapies

Babatunde OO, Bibby MG, Atala A, Almeida-Porada G, Porada CD (2026) In utero HSC transplantation for sickle cell disease: A potential therapeutic approach that overcomes complications of current therapies. Prenat Diagn doi: 10.1002/pd.70142 PMID: 41936060 Objective: To examine current evidence and recent advances for treatment of sickle cell disease (SCD). Summary: Biotinylated anti‐c‐kit/CD117 mAb coupled

In utero HSC transplantation for sickle cell disease: A potential therapeutic approach that overcomes complications of current therapies Read More »

Photodynamic therapy-based strategies targeted at cancer stem cells: A scoping review

Serambeque B, Dias I, Mestre C, Marto CM, Botelho MF, Carvalho MJ, Laranjo M (2026) Photodynamic therapy-based strategies targeted at cancer stem cells: A scoping review. Cancers (Basel) 18(7):1162. doi: 10.3390/cancers18071162 PMID: 41976384 Objective: To examine strategies for targeting cancer stem cells using photodynamic therapy. Summary: Photochemical internalization (PCI) is a widely adopted approach for

Photodynamic therapy-based strategies targeted at cancer stem cells: A scoping review Read More »

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