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Targeting Trends 2018 Review

Below are links to view the 2018 annual review newsletter Targeting Trends. You can also download the full PDF here. If you would like to be added to the mailing list, please subscribe here.

News from Science: Nppb in Itch / CRH antibody cross-reactivity

In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.1  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.2   The figure below illustrates the specificity […]

News from Science: Nppb in Itch / CRH antibody cross-reactivity

Cat. #IT-69 Nppb-SAP Meng, Qing-Tao and Liu, Xian-Yu and Liu, Xue-Ting and Barry, Devin M. and Jin, Hua and Yang, Qianyi and Sun, Yu and Wan, Li and Jin, Jin-Hua and Munanairi, Admire and Kim, Ray and Yin, Jun and Tao, Ailin and Chen, Zhou-Feng, Cross-Talk between Distinct Receptors Shapes Itch Behavior in the Spinal […]

CTB-SAP and Targeted Ablation of dCSF-CNs

Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease.  Qiu M, Li J, Tan L, Zhang M, Zhou G, Zeng T, Li A.  Front Physiol. https://doi.org/10.3389/fphys.2018.01640 CTB-SAP (Cat. #KIT-14) CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in […]

NGF p75 antibody for brain research

Two more publications this week using an ATS exclusive antibody: NGFR (mu p75) Antibody (Cat. #AB-N38) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of Golgi structure. Pottorf T, Mann A, Fross S, Mansel C, & Vohra BPS. (2018). Neurochem Intl Objective:  investigated the link between NMNAT2 loss, Golgi fragmentation and axon […]

New Publications – Retinal Ganglion Cells and Cerebellar Purkinje Cells

Two publications out this week using ATS antibodies: Anti-Melanopsin (Cat. #AB-N38) and Anti-Metabotrophic Glutamate Receptor 2 (mGluR2; Cat. #AB-N32) Sabbah S et al.  Synaptic circuits for irradiance coding by intrinsically photosensitive retinal ganglion cells. (2018) bioRxiv  doi: https://doi.org/10.1101/442954 Objective:  To explore the synaptic networks responsible for the unique capacity of intrinsically photosensitive retinal ganglion cells (ipRGCs) to […]

Screening antibodies for cancer therapeutics

Conservation of Oncofetal Antigens on Human Embryonic Stem Cells Enables Discovery of Monoclonal Antibodies against Cancer. Tan HL, Yong C, Tan BZ, Fong WJ, Padmanabhan J, Chin A, Ding V, Lau A, Zheng L, Bi X, Yang Y, & Choo A. (2018). Scientific Reports, 8 (1):11608. This study used both Hum-ZAP (Cat. #IT-22) and Streptavidin-ZAP (Cat. #IT-27) […]

Cytoplasmic Delivery of Aptamers

Screening Aptamers as Targeting Agents to deliver Payloads. Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for […]

Dedicated Scientific Staff

The ATS scientific staff is dedicated to providing quality targeting tools and prompt, courteous support for all of our research products. L to R: Leonardo, Raschel, Sydney, Patrick, Miguel.

Antibody Samples – Tools to study Programmed Cell Death

Antibodies you can rely on. The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo […]