3. Fujita, et al. Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model (2018). Korean J Pain. AB-N33AP; Anti-NK-1 receptor. 4. SGrillo, et al. Melanopsin retinal ganglion cells are not labeled in Thy-1YFP-16 transgenic mice (2018). Neuroreport. AB-N39: Anti-Melanopsin. 5. Hamano, et al. Extracellular […]
The following products have been discontinued. Please check out IT-06 Mac-1-SAP to eliminate Mac-1 positive (CD11b positive) cells in mouse/human. Discontinued: AB-N06, IT-33, KIT-33
In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.[1] Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.[2] Melanopsin has since been found to be […]
Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model. Fujita M, Fukuda T, Sato Y, Takasusuki T, & Tanaka M. (2018). Korean J Pain, 31 (1):10-15. Applications include immunohistochemistry, flow cytometry, immunoblotting, and ELISA. The objective in the study published by Fujita et al. […]
Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and […]
Li J, Rao D, & Gibbs RB. Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. (2018). Neuroscience, 384 203-213. Dose: Rats received intraseptal injections of 2.0 ml (0.2 mg/ml) or icv injections of 0.4 mcg. Lesions resulted in loss of ChAT-positive cells in the septum, and […]
F055 Behavioral effects of immunotoxin 192IgG-saporin depends on the type of its administration to rats. Yulia Dobryakova, Alexey Bolshakov, Maria Zaichenko, Mikhail Stepanichev, Vlaimir Markevich featuring IT-01 192-IgG-SAP (Sunday 2:00pm-5:30pm) It is known that degeneration of cholinergic neurons is one of key events during development of Alzheimer’s disease. We used immunotoxin 192IgG-saporin, a conjugate of antibody to […]
Targeting Results from FENS (The Federation of European Neuroscience Societies) will be presented at this year’s meeting in Berlin. Advanced Targeting Systems congratulates the researchers on their work and looks forward to viewing the posters and interacting with scientists from around the world at this year’s meeting in Berlin. Come visit us at Booth 165 […]
Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse […]
Enhanced Targeting of Triple-Negative Breast Carcinoma and Malignant Melanoma by Photochemical Internalization of CSPG4-Targeting Immunotoxins. Eng MS, Kaur J, Prasmickaite L, Engesaeter BO, Weyergang A, Skarpen E, Berg K, Rosenblum MG, Maelandsmo GM, Hogset A, Ferrone S, & Selbo PK. (2018). Photochemical & Photobiological Sciences 17(5):539-551. Conclusion: The combination of the drug delivery technology PCI […]