Author name: Kristen Hartman

PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway

Wang W, Zhang Y, Li L, Xu Y, Zhang W, Chen X, Wang X, Tong G, Zhang P (2026) PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway. Biochem Biophys Res Commun 808:153462. doi: 10.1016/j.bbrc.2026.153462 PMID: 41702189 Objective: To investigate the mechanism of PACAP in ipRGC–VLPO light-induced sleep. Summary: Partial ablation of ipRGCs by Melanopsin-SAP […]

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Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers

Tendler S, De Gregorio R, Balderes P, Michel AL, Hoang TT, Bauer D, Tully KM, Korsen JA, Lorenz IC, Khan AG, Carter L, Vergnolle O, Lebedeva IV, Nyakatura EK, Bodei L, Morris MJ, Poirier JT, Rudin CM, Lewis JS (2026) Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers. Proc Natl Acad Sci U

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An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins

Yang Y, Jia H, Yang L, He B, Zhang K, Liu H (2026) An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins. Int J Nanomedicine 21:1-14. doi: 10.2147/IJN.S557672 Summary: The authors report a novel AIEgen (Aggregation-induced emission luminogen) -based carrier, MTPABP-Guided-Intracellular-Carrier (MAGIC), that achieves high efficiency in delivering native proteins into the cytosol. MAGIC

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Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice

Gao JL, Li Z, Calderon-Perez R, Pavek A, Kim L, McDermott DH, Murphy PM (2026) Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice. J Clin Invest 136(5):e202073. doi: 10.1172/JCI202073 PMID: 41505207 Objective: To provide proof of principle that CRISPR/Cas9-mediated inactivation of the Cxcr4 disease allele, combined with nongenotoxic HSC- targeted

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Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model

Gupta S (2026) Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model. Univ Calgary Thesis. Objective: To confirm that the SSP-SAP model reproduces the defining features of human TLE and that a primary and selective GABAergic defect is sufficient to trigger epileptogenesis that results in TLE-HS+. Summary: The author hypothesized that intrahippocampal

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Lesion-remote astrocytes govern microglia-mediated white matter repair

McCallum S, Suresh KB, Islam TS, Tripathi MK, Saustad AW, Shelest O, Patil A, Lee D, Kwon B, Leitholf K, Yenokian I, Shaka SE, Beveridge CH, Manchandra P, Randolph CE, Meares GP, Dutta R, Plummer J, Calsavara VF, Kawaguchi R, Knott SRV, Chopra G, Burda JE (2026) Lesion-remote astrocytes govern microglia-mediated white matter repair. Nature

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