Herrerias A, Oliverio A, Dvorácskó S, Thyagarajan A, Chedester L, Liu J, Cinar R, Iyer MR, Kunos G, Godlewski G (2025) CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice. Mol Psychiatry doi: 10.1038/s41380-025-03266-9 PMID: 40975751 Objective: To investigate how peripheral CB1 receptors on vagal afferent neurons regulate voluntary […]
Kobayashi K, Miyazaki Y, Sakamoto N, Yamamoto M, Nagat N, Murata T (2025) Long-term scratching analysis of mice using machine learning. PNAS Nexus pgaf292. doi: 10.1093/pnasnexus/pgaf292 Objective: To objectively quantify mouse scratching behavior across light and dark cycles using automated, long-term machine learning analysis. Summary: Naïve BALB/c mice exhibited more frequent and persistent scratching during
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Alampi MM, Kozlíková M, Mariangeli M, Civita S, Delcanale P, Mussini A, Diaspro A, Bianchini P, Weyergang A, Skarpen E, Berg K, Viappiani C, Abbruzzetti S, Selbo PK (2025) Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab. Biomed Pharmacother 191:118550. doi: 10.1016/j.biopha.2025.118550 PMID: 40946581 Objective: To optimize the cytotoxic efficacy of a photoimmunoconjugate
We’re highlighting one of our antibodies, a rabbit polyclonal against Melanopsin. This antibody is offered as both serum (AB-N38) and affinity purified (AB-N39). Intrinsically photosensitive retinal ganglion cells (ipRGCs) are cells that express melanopsin. These ipRGCs, with their long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Our
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Hor CC (2025) The dual nature of cold: Unraveling the neural circuits for cool sensing and cold allodynia. Univ Michigan Objective: To elucidate the neural mechanisms underlying innocuous cool sensation from the skin to the brain and the spinal circuitry changes that drive cold allodynia under pathological conditions. Summary: The study identified distinct spinal interneuron
Lipari NR (2025) Investigating anxiety-like behaviors and basolateral amygdala dysfunction in a novel rat model of Parkinson’s disease. SUNY Binghamton Thesis. Objective: To create a unique model of PD with improved face validity, and non-motor symptoms. Summary: This work helped further characterize motor and non-motor symptoms while providing potential underlying physiological markers for early disease
Handfield J (2025) Focal irradiation regulates distal neural stem and progenitor cell behaviour. Univ Toronto Thesis. Objective: To investigate how focal irradiation (IR) impacts non-irradiated neural stem cell (NSC) niches along the neuraxis and whether microglia mediate these long-distance effects. Summary: Focal cranial IR decreased spinal cord-derived NSCs, while spinal IR reduced neuroblasts and NSCs
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Nierkens S, Lindemans CA (2025) Hole in one: CD137-ADC eliminates GVHD. Blood 146(9):1038-1040. doi: 10.1182/blood.2025029867 PMID: 40875553 Objective: To show that a single dose of CD137-ADC can prevent acute graft-versus-host disease (GVHD) while pre-serving immune reconstitution in a nonhuman primate (NHP) model of stem cell transplantation. Summary: Results showed that animals treated with CD137-ADC exhibited
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Diamantoudis SC, Miliotou AN, Galatou E, Telliou S, Sideris K, Grigoriadis N, Vizirianakis IS (2025) Assessing the hematological cancer stem cell landscape to improve immunotherapy clinical decisions. Biocell doi: 10.32604/biocell.2025.067216 Objective: To combine existing information and clinical evidence to assess and bring to the spotlight targets related to Hematological cancer stem cells (HCSCs) that can
Question I am using your Fab-ZAP Human (IT-51) and I want to know how many antibody molecules can a secondary antibody conjugate theoretically bind to? Answer A whole IgG (bivalent) secondary antibody in theory is capable of binding two antigen molecules. Since our Fab-ZAP conjugates actually use a monovalent secondary antibody, in theory they would
How many antibody molecules can ZAP bind to? What’s the recommended concentration? Read More »