Keilholz AN, Lopez S, Attari M, Nguyen NP, Henry J, Smith CL, Feldberg A, Osman KL, Golzy M, Bunyak F, Lever TE, Nichols NL (2026) Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration. J Neurophysiol doi: 10.1152/jn.00631.2024 PMID: 42012472
Objective: To investigate the effects of a high-repetition/low-resistance tongue exercise paradigm on XII axis survival, structure, and output in adult male Sprague Dawley rats.
Summary: Intralingual injections of CTB-SAP result in decreased XII motor neuron survival and degenerative changes in the XII nerve consistent with what is seen in many motor neuron diseases. While these deficits are not mitigated by tongue exercise, the authors observed increased microglial fractional area/density in the XII nucleus of CTB-SAP + exercise rats.
Usage: Rats received intralingual injection of either CTB-SAP (IT-14) or unconjugated CTB + SAP (PR-01).
Related Products: CTB-SAP (Cat. #IT-14), Saporin (Cat. #PR-01)