Author name: Kristen Hartman

Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis

Lim-Paik C, Zeng Q, Beyea R, Boohaker R, Wang P (2026) Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis. Biomedicines 14(3):626. doi: 10.3390/biomedicines14030626 Objective: To identify structurally defined novel natural saponins and evaluate their ability to enhance anticancer cytotoxicity. Summary: Saponins have recently emerged as promising natural products that […]

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40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway

Chen J, Xu T, Zhang C, Li L, He Y, Sun Z, He J, Yao Z, Cai P, Huang Y, Ye F, Guo W, Jia M, Qu J, Chen JF, Zhang Y (2026) 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway. Cell Res doi: 10.1038/s41422-026-01227-7 PMID: 41781500 Objective: To

40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway Read More »

uPAR-targeting cytotoxic antibody–drug conjugates selectively deplete proinflammatory myeloid cells for autoimmune indications

Xiang H, Mortenson GP, Lang SB, Jakkaraju S, Chirala A, Zhu Y, Jia M, Wen J, Chen Y, Baghela A, Chen YC, Sze MA, Hegde LG, Zhang-Hoover J, Willingham A, Handa M, Chi A, Baltus GA, Kamath RV, Levesque M, Vollmann EH (2026) uPAR-targeting cytotoxic antibody–drug conjugates selectively deplete proinflammatory myeloid cells for autoimmune indications.

uPAR-targeting cytotoxic antibody–drug conjugates selectively deplete proinflammatory myeloid cells for autoimmune indications Read More »

Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice

Hamakubo S, Komatsu N, Kosai A, Kuroda M, Sawada M, Shimizu R, Ohashi R, Suenaga H, Hamakubo T, Abe T (2026) Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice. Biomedicines 14:573. doi: 10.3390/biomedicines14030573 Objective: To investigate the in vivo therapeutic efficacy of intelligent Targeted Antibody Phototherapy (iTAP), utilizing

Enhanced antitumor efficacy of a combination of immunotoxin and photosensitizer under illumination in xenograft mice Read More »

PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway

Wang W, Zhang Y, Li L, Xu Y, Zhang W, Chen X, Wang X, Tong G, Zhang P (2026) PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway. Biochem Biophys Res Commun 808:153462. doi: 10.1016/j.bbrc.2026.153462 PMID: 41702189 Objective: To investigate the mechanism of PACAP in ipRGC–VLPO light-induced sleep. Summary: Partial ablation of ipRGCs by Melanopsin-SAP

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Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers

Tendler S, De Gregorio R, Balderes P, Michel AL, Hoang TT, Bauer D, Tully KM, Korsen JA, Lorenz IC, Khan AG, Carter L, Vergnolle O, Lebedeva IV, Nyakatura EK, Bodei L, Morris MJ, Poirier JT, Rudin CM, Lewis JS (2026) Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers. Proc Natl Acad Sci U

Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers Read More »

Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8

Maria NI, Xia Y, Raparia C, Lin K, Martinez S, Yi Z, Zhang W, Aziz M, Wang P, Guerra M, Salmon, J, Sones JL, Arazi A, Hoover P, Davidson A (2026) Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8. bioRxiv 2026.02.07.701591. doi: 10.64898/2026.02.07.701591 Objective: To explore human TLR8 (huTLR8) in

Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8 Read More »

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