Targeted choroidal injury to understand retinal degeneration
episode11, episode35
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Eliminating CD150-expressing HSCs
episode10, episode34
Eliminating CD150-expressing HSCs Read More »
PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway
Wang W, Zhang Y, Li L, Xu Y, Zhang W, Chen X, Wang X, Tong G, Zhang P (2026) PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway. Biochem Biophys Res Commun 808:153462. doi: 10.1016/j.bbrc.2026.153462 PMID: 41702189 Objective: To investigate the mechanism of PACAP in ipRGC–VLPO light-induced sleep. Summary: Partial ablation of ipRGCs by Melanopsin-SAP
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Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers
Tendler S, De Gregorio R, Balderes P, Michel AL, Hoang TT, Bauer D, Tully KM, Korsen JA, Lorenz IC, Khan AG, Carter L, Vergnolle O, Lebedeva IV, Nyakatura EK, Bodei L, Morris MJ, Poirier JT, Rudin CM, Lewis JS (2026) Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers. Proc Natl Acad Sci U
Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8
Maria NI, Xia Y, Raparia C, Lin K, Martinez S, Yi Z, Zhang W, Aziz M, Wang P, Guerra M, Salmon, J, Sones JL, Arazi A, Hoover P, Davidson A (2026) Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8. bioRxiv 2026.02.07.701591. doi: 10.64898/2026.02.07.701591 Objective: To explore human TLR8 (huTLR8) in
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An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins
Yang Y, Jia H, Yang L, He B, Zhang K, Liu H (2026) An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins. Int J Nanomedicine 21:1-14. doi: 10.2147/IJN.S557672 Summary: The authors report a novel AIEgen (Aggregation-induced emission luminogen) -based carrier, MTPABP-Guided-Intracellular-Carrier (MAGIC), that achieves high efficiency in delivering native proteins into the cytosol. MAGIC
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Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice
Gao JL, Li Z, Calderon-Perez R, Pavek A, Kim L, McDermott DH, Murphy PM (2026) Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice. J Clin Invest 136(5):e202073. doi: 10.1172/JCI202073 PMID: 41505207 Objective: To provide proof of principle that CRISPR/Cas9-mediated inactivation of the Cxcr4 disease allele, combined with nongenotoxic HSC- targeted
Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model
Gupta S (2026) Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model. Univ Calgary Thesis. Objective: To confirm that the SSP-SAP model reproduces the defining features of human TLE and that a primary and selective GABAergic defect is sufficient to trigger epileptogenesis that results in TLE-HS+. Summary: The author hypothesized that intrahippocampal
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Lesion-remote astrocytes govern microglia-mediated white matter repair
McCallum S, Suresh KB, Islam TS, Tripathi MK, Saustad AW, Shelest O, Patil A, Lee D, Kwon B, Leitholf K, Yenokian I, Shaka SE, Beveridge CH, Manchandra P, Randolph CE, Meares GP, Dutta R, Plummer J, Calsavara VF, Kawaguchi R, Knott SRV, Chopra G, Burda JE (2026) Lesion-remote astrocytes govern microglia-mediated white matter repair. Nature
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Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis
Cheng K, Zhang F, Bao Y, Xu Z, Kong H, Yuan D, Zheng Z, Zhao YD, Xia J (2026) Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis. Theranostics 16(6):2705-2720. doi: 10.7150/thno.121865 PMID: 41510156 Objective: To demonstrate that curcumin, the active ingredient in the spice turmeric, forms phase-separated fluorescent coacervates when diluted from a