Antagonists vs. Targeted Toxins
episode9, episode33
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Meningeal macrophages mask incision pain sensitization in male rats
Kolahdouzan M, Ghazisaeidi S, Tu Y, Muley M, Gambeta E, Salter M (2025) Meningeal macrophages mask incision pain sensitization in male rats. Mol Pain doi: 10.1177/17448069251383593 Objective: To investigate whether CD206+macrophages in the meninges play a role in regulating nociception and pain hypersensitivity. Summary: The results indicate that while CD206+ meningeal macrophages do not regulate
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The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex
Shang Y, Gan X, Dang Y, Liu J, Liu P (2025) The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex. J Cell Mol Med 29(15):e70794. doi: 10.1111/jcmm.70794 PMID: 40801824 Objective: To furnish a robust theoretical foundation for the prospective utilization of polarity proteins and their complex as cancer markers and therapeutic
Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain
Yuan M, Zhang L, Zhu H, Xie M (2025) Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain. PLoS One 20(8):e0330207. doi: 10.1371/journal.pone.0330207 PMID: 40811566 Objective: To examine the expression and localization of BDNF and NE neuron-specific proteins in the locus coeruleus (LC) of mice with cancer-induced
Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics
Park S, Lu GL, Zheng YC, Davison EK, Li Y (2025) Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics. Cancers (Basel) 17(16):2628. doi: 10.3390/cancers17162628 PMID: 40867257 Objective: To explore how nanoparticle-based drug delivery systems can address the challenge of resistance to chemotherapy and targeted therapy by improving drug accumulation in tumors, enhancing targeting
A molecular and spinal circuit basis for the functional segregation of itch and pain
Noh M, Corrigan KA, Williams SG, Peirs C, Leone MJ, Headrick DJ, Guvercin M, Lee S, Phan BN, Yeramosu D, Babu S, Brown AR, Van De Weerd R, Zhao X, Dunn RP, Mathys H, Pfenning AR, Seal RP (2025) A molecular and spinal circuit basis for the functional segregation of itch and pain. bioRxiv 2025.07.31.667966.
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Nociception and acute pain: Neurotransmitters and neuromodulators
Windhorst U, Dibaj P (2025) Nociception and acute pain: Neurotransmitters and neuromodulators. Preprints.org preprints202508.0487.v1. doi: 10.20944/preprints202508.0487.v1 Objective: To review the huge variety of additional neurotransmitters, neuromodulators and hormones in the nociceptive and pain system Summary: Nociception and acute pain are governed by a dynamic interplay of structures and substances, modulated by internal and external factors,
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The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Nie AA, Taylor BK (2025) The pharmacotherapeutic potential of neuropeptide Y for chronic pain. J Intern Med doi: 10.1111/joim.20118 PMID: 40754889 Objective: To evaluate how neuropeptide Y (NPY) and its receptor subtypes (Y1 and Y2) regulate acute and chronic pain, and to explore the therapeutic potential of targeting these pathways for the treatment of neuropathic
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