Du R, Zhang Y, Wu S, Zixing W, Jing W (2025) Progress, opportunity, and perspective on long term preservation of extracellular vesicles. SSRN ssrn.5553381. doi: 10.2139/ssrn.5553381 Objective: To provide an overview of the biology, function, and biomedical application of Extracellular vesicles (EVs) and introduce the method to evaluate the storage stability of EVs. Summary: While […]
Gan JH, Wang MJ, Li CY, Huang Y, Liu ZH, Bai WL, Xu WJ, Sun MH, Kang MT, Morgan I, Wang N, Li SM (2025) The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice. Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-025-06950-2 PMID: 41026222
Leanza MH, Storelli E, D’Arco D, de Leo G, Kleiner G, Arancio L, Capodieci G, Gulino R, Bava A, Leanza G (2025) Cerebellar contributions to spatial learning and memory: Effects of discrete immunotoxic lesions. Int J Mol Sci 26(19):9553. doi: 10.3390/ijms26199553 PMID: 41096819 Objective: To analyze the behavioral and anatomical effects of discrete injections, in
Herrerias A, Oliverio A, Dvorácskó S, Thyagarajan A, Chedester L, Liu J, Cinar R, Iyer MR, Kunos G, Godlewski G (2026) CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice. Mol Psychiatry 31(1):48-61. doi: 10.1038/s41380-025-03266-9 PMID: 40975751 Objective: To investigate how peripheral CB1 receptors on vagal afferent neurons regulate
Kobayashi K, Miyazaki Y, Sakamoto N, Yamamoto M, Nagat N, Murata T (2025) Long-term scratching analysis of mice using machine learning. PNAS Nexus 4(9):pgaf292. doi: 10.1093/pnasnexus/pgaf292 PMID: 41030291 Objective: To objectively quantify mouse scratching behavior across light and dark cycles using automated, long-term machine learning analysis. Summary: Naïve BALB/c mice exhibited more frequent and persistent
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Alampi MM, Kozlíková M, Mariangeli M, Civita S, Delcanale P, Mussini A, Diaspro A, Bianchini P, Weyergang A, Skarpen E, Berg K, Viappiani C, Abbruzzetti S, Selbo PK (2025) Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab. Biomed Pharmacother 191:118550. doi: 10.1016/j.biopha.2025.118550 PMID: 40946581 Objective: To optimize the cytotoxic efficacy of a photoimmunoconjugate
We’re highlighting one of our antibodies, a rabbit polyclonal against Melanopsin. This antibody is offered as both serum (AB-N38) and affinity purified (AB-N39). Intrinsically photosensitive retinal ganglion cells (ipRGCs) are cells that express melanopsin. These ipRGCs, with their long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Our
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Hor CC (2025) The dual nature of cold: Unraveling the neural circuits for cool sensing and cold allodynia. Univ Michigan Thesis. Objective: To elucidate the neural mechanisms underlying innocuous cool sensation from the skin to the brain and the spinal circuitry changes that drive cold allodynia under pathological conditions. Summary: The study identified distinct spinal
Handfield J (2025) Focal irradiation regulates distal neural stem and progenitor cell behaviour. Univ Toronto Thesis. Objective: To investigate how focal irradiation (IR) impacts non-irradiated neural stem cell (NSC) niches along the neuraxis and whether microglia mediate these long-distance effects. Summary: Focal cranial IR decreased spinal cord-derived NSCs, while spinal IR reduced neuroblasts and NSCs
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Lipari NR (2025) Investigating anxiety-like behaviors and basolateral amygdala dysfunction in a novel rat model of Parkinson’s disease. SUNY Binghamton Thesis. Objective: To create a unique model of PD with improved face validity, and non-motor symptoms. Summary: This work helped further characterize motor and non-motor symptoms while providing potential underlying physiological markers for early disease