Author name: Kristen Hartman

An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins

Yang Y, Jia H, Yang L, He B, Zhang K, Liu H (2026) An AIEgen-based carrier enables efficient cytosolic delivery of bioactive proteins. Int J Nanomedicine 21:1-14. doi: 10.2147/IJN.S557672 Summary: The authors report a novel AIEgen (Aggregation-induced emission luminogen) -based carrier, MTPABP-Guided-Intracellular-Carrier (MAGIC), that achieves high efficiency in delivering native proteins into the cytosol. MAGIC […]

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Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice

Gao JL, Li Z, Calderon-Perez R, Pavek A, Kim L, McDermott DH, Murphy PM (2026) Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice. J Clin Invest 136(5):e202073. doi: 10.1172/JCI202073 PMID: 41505207 Objective: To provide proof of principle that CRISPR/Cas9-mediated inactivation of the Cxcr4 disease allele, combined with nongenotoxic HSC- targeted

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Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model

Gupta S (2026) Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model. Univ Calgary Thesis. Objective: To confirm that the SSP-SAP model reproduces the defining features of human TLE and that a primary and selective GABAergic defect is sufficient to trigger epileptogenesis that results in TLE-HS+. Summary: The author hypothesized that intrahippocampal

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Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis

Cheng K, Zhang F, Bao Y, Xu Z, Kong H, Yuan D, Zheng Z, Zhao YD, Xia J (2026) Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis. Theranostics 16(6):2705-2720. doi: 10.7150/thno.121865 PMID: 41510156 Objective: To demonstrate that curcumin, the active ingredient in the spice turmeric, forms phase-separated fluorescent coacervates when diluted from a

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Lesion-remote astrocytes govern microglia-mediated white matter repair

McCallum S, Suresh KB, Islam TS, Tripathi MK, Saustad AW, Shelest O, Patil A, Lee D, Kwon B, Leitholf K, Yenokian I, Shaka SE, Beveridge CH, Manchandra P, Randolph CE, Meares GP, Dutta R, Plummer J, Calsavara VF, Kawaguchi R, Knott SRV, Chopra G, Burda JE (2026) Lesion-remote astrocytes govern microglia-mediated white matter repair. Nature

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Summarizing the role of selected adipokines in parkinson’s disease: What is known about leptin, adiponectin, resistin, visfatin, and progranulin in neurodegeneration?

Milanowski J, Pawłowska M, Woźniak A, Szewczyk-Golec K (2025) Summarizing the role of selected adipokines in parkinson’s disease: What is known about leptin, adiponectin, resistin, visfatin, and progranulin in neurodegeneration?. Molecules 30(22):4431. doi: 10.3390/molecules30224431 PMID: 41302488 Objective: To summarize current evidence and identify potential targets for Parkinson’s disease (PD) treatment or as biomarkers of disease

Summarizing the role of selected adipokines in parkinson’s disease: What is known about leptin, adiponectin, resistin, visfatin, and progranulin in neurodegeneration? Read More »

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