Gupta S (2026) Modelling Temporal Lobe Epilepsy with Sclerosis in the SSP-Saporin ‘Trojan Horse’ Model. Univ Calgary Thesis.
Objective: To confirm that the SSP-SAP model reproduces the defining features of human TLE and that a primary and selective GABAergic defect is sufficient to trigger epileptogenesis that results in TLE-HS+.
Summary: The author hypothesized that intrahippocampal SSP-SAP administration will first cause rats to exhibit reactive behavioural seizures, followed by self-generated epileptiform activity that will develop into electrographic seizures. Rats will also develop TLE anatomically characterized by progressive principal cell loss and astrogliosis.
Usage: Rats were stereotaxically injected with 150 nL of SSP-SAP (IT-11, 0.04 ng/nL) at 4 sites in the hippocampus.
Related Products: SSP-SAP (Cat. #IT-11)