Author name: Kristen Hartman

Hole in one: CD137-ADC eliminates GVHD

Nierkens S, Lindemans CA (2025) Hole in one: CD137-ADC eliminates GVHD. Blood 146(9):1038-1040. doi: 10.1182/blood.2025029867 PMID: 40875553 Objective: To show that a single dose of CD137-ADC can prevent acute graft-versus-host disease (GVHD) while pre-serving immune reconstitution in a nonhuman primate (NHP) model of stem cell transplantation. Summary: Results showed that animals treated with CD137-ADC exhibited […]

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Assessing the hematological cancer stem cell landscape to improve immunotherapy clinical decisions

Diamantoudis SC, Miliotou AN, Galatou E, Telliou S, Sideris K, Grigoriadis N, Vizirianakis IS (2025) Assessing the hematological cancer stem cell landscape to improve immunotherapy clinical decisions. Biocell 49(10):1799-1858. doi: 10.32604/biocell.2025.067216 Objective: To combine existing information and clinical evidence to assess and bring to the spotlight targets related to Hematological cancer stem cells (HCSCs) that

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How many antibody molecules can ZAP bind to? What’s the recommended concentration?

Question I am using your Fab-ZAP Human (IT-51) and I want to know how many antibody molecules can a secondary antibody conjugate theoretically bind to? Answer A whole IgG (bivalent) secondary antibody in theory is capable of binding two antigen molecules.  Since our Fab-ZAP conjugates actually use a monovalent secondary antibody, in theory they would

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Meningeal macrophages mask incision pain sensitization in male rats

Kolahdouzan M, Ghazisaeidi S, Tu Y, Muley M, Gambeta E, Salter M (2025) Meningeal macrophages mask incision pain sensitization in male rats. Mol Pain 21. doi: 10.1177/17448069251383593 PMID: 40958149 Objective: To investigate whether CD206+macrophages in the meninges play a role in regulating nociception and pain hypersensitivity. Summary: The results indicate that while CD206+ meningeal macrophages

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The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex

Shang Y, Gan X, Dang Y, Liu J, Liu P (2025) The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex. J Cell Mol Med 29(15):e70794. doi: 10.1111/jcmm.70794 PMID: 40801824 Objective: To furnish a robust theoretical foundation for the prospective utilization of polarity proteins and their complex as cancer markers and therapeutic

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Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain

Yuan M, Zhang L, Zhu H, Xie M (2025) Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain. PLoS One 20(8):e0330207. doi: 10.1371/journal.pone.0330207 PMID: 40811566 Objective: To examine the expression and localization of BDNF and NE neuron-specific proteins in the locus coeruleus (LC) of mice with cancer-induced

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Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics

Park S, Lu GL, Zheng YC, Davison EK, Li Y (2025) Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics. Cancers (Basel) 17(16):2628. doi: 10.3390/cancers17162628 PMID: 40867257 Objective: To explore how nanoparticle-based drug delivery systems can address the challenge of resistance to chemotherapy and targeted therapy by improving drug accumulation in tumors, enhancing targeting

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A molecular and spinal circuit basis for the functional segregation of itch and pain

Noh M, Corrigan KA, Williams SG, Peirs C, Leone MJ, Headrick DJ, Guvercin M, Lee S, Phan BN, Yeramosu D, Babu S, Brown AR, Van De Weerd R, Zhao X, Dunn RP, Mathys H, Pfenning AR, Seal RP (2025) A molecular and spinal circuit basis for the functional segregation of itch and pain. bioRxiv 2025.07.31.667966.

A molecular and spinal circuit basis for the functional segregation of itch and pain Read More »

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