Author name: Kristen Hartman

Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit

Yu C, Li M, Shen F, Gao S, Wang J, He C, Wang L, Wu Y, Du Y (2025) Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit. Chin Med 20(1):188. doi: 10.1186/s13020-025-01230-x PMID: 41233833 Objective: To demonstrate efficacy in ameliorating Alzheimer’s disease (AD)-related […]

Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit Read More »

Does amyotrophic lateral sclerosis (als) have metabolic causes from human evolution?

Spedding M (2025) Does amyotrophic lateral sclerosis (als) have metabolic causes from human evolution?. Cells 14(21):1734. doi: 10.3390/cells14211734 PMID: 41227379 Objective: To evaluate if recent human genetic variants play major roles in Amyotrophic Lateral Sclerosis (ALS), changing metabolism. Summary: The authors reviewed Cholera Toxin B (CTB) binding as a tool to study GM1 and fucosylated

Does amyotrophic lateral sclerosis (als) have metabolic causes from human evolution? Read More »

Immune tolerance induction using the thyrotropin receptor epitope 78-94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice

Inaba H, Nonaka I, Hashimoto D, Hirono M, Morita S, Kimura H, Iwakura H, Akamizu T, Nakata M (2025) Immune tolerance induction using the thyrotropin receptor epitope 78-94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice. Front Immunol 16:1633350. doi: 10.3389/fimmu.2025.1633350 PMID: 41256857 Objective: To investigate whether pre-immunization with the immunodominant TSH-R–derived peptide spanning residues

Immune tolerance induction using the thyrotropin receptor epitope 78-94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice Read More »

Real-time in vivo monitoring of cholinergic neurotransmission in the mouse brain using a microelectrochemical choline biosensor

Doyle S, Doran MM, Cunningham C, Lowry JP (2025) Real-time in vivo monitoring of cholinergic neurotransmission in the mouse brain using a microelectrochemical choline biosensor. Eur J Neurosci 62)9):e70291. doi: 10.1111/ejn.70291 PMID: 41185145 Objective: To refine an established choline oxidase (ChOx) microelectrochemical biosensor to validate its use for long-term recording in the freely moving mouse.

Real-time in vivo monitoring of cholinergic neurotransmission in the mouse brain using a microelectrochemical choline biosensor Read More »

Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors

Tateda Y, Suzuki T, Sato T, Izuhara K, Ise K, Shimada H, Murakami K, Murakami K, Nakamura Y, Ohta N (2025) Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors. Histol Histopathol 25013. doi: 10.14670/HH-25-013 PMID: 41178409 Objective: To investigate the expression and role of D-β-aspartic acid and periostin in the formation

Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors Read More »

Retinal glia regulate development of the circadian photoentrainment circuit

Brown TW, Vilallongue N, Hales SC, Srikanta S, Rochon PL, Rangel Olguin AG, Waxman SB, Tufford A, Van Prooijen J, Krishnaswamy A, Cermakian N, Cayouette M (2025) Retinal glia regulate development of the circadian photoentrainment circuit. Cell Rep 44(11):116464. doi: 10.1016/j.celrep.2025.116464 PMID: 41150857 Objective: To examine the role of Müller glia in the development of

Retinal glia regulate development of the circadian photoentrainment circuit Read More »

Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2025) Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning. Blood ICT 1(3):100012. doi: 10.1016/j.bict.2025.100012 PMID: 41574174 Objective: To develop and validate a modular streptavidin based antibody drug conjugate platform for optimizing antibody mediated hematopoietic stem cell transplant conditioning. Summary: The

Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning Read More »

Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer

Park JS, Kenum C, He L, Khan AG, Pohl MA, White TE, Kodangattil SR, Rudin CM, Balderes PJ, Lorenz IC, Massagué J, anesh K (2025) Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer. bioRxiv 2025.10.01.679843. doi: 10.1101/2025.10.01.679843 PMID: 41256399 Objective: To develop L1CAM-targeted antibody-drug conjugates (ADCs) using high-affinity monoclonal antibodies and assess their

Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer Read More »

Progress, opportunity, and perspective on long term preservation of extracellular vesicles

Du R, Zhang Y, Wu S, Zixing W, Jing W (2025) Progress, opportunity, and perspective on long term preservation of extracellular vesicles. SSRN ssrn.5553381. doi: 10.2139/ssrn.5553381 Objective: To provide an overview of the biology, function, and biomedical application of Extracellular vesicles (EVs) and introduce the method to evaluate the storage stability of EVs. Summary: While

Progress, opportunity, and perspective on long term preservation of extracellular vesicles Read More »

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