Huang C, Gudlur S, Maricar S, Chen Z, Shebanova A, Sun Y, Saliba V, Xu C, Zou Y, Zhang J, Boujday S, Miserez A (2025) Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies. APL Bioeng 9(3):036101. doi: 10.1063/5.0279643 PMID: 40642324 Objective: To present a solution for intracellular delivery of large molecules […]
Nazmuddin M, Stammes MA, Klink PC, Vernes MK, Bakker J, Langermans JAM, van Laar T, Philippens IHCHM (2025) Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta). J Neuropathol Exp Neurol nlaf081. doi: 10.1093/jnen/nlaf081 PMID: 40673943 Objective: To describe a procedure to
Ishtiaque S, Ahman S, Farooqui A, Siddiqui MH, Faridi SA (2025) Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review. IJERT 13(6) Objective: To examine innovative multifunctional nanoparticle strategies designed to overcome transporter-mediated efflux mechanism. Summary: Authors analyze nanocarrier platforms enabling targeted co-delivery of chemotherapeutics with transporter inhibitors, gene-silencing approaches
Noble EE, Harris RBS (2025) Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats. Am J Physiol Endocrinol Metab 329(1):E1-E17. doi: 10.1152/ajpendo.00090.2025 PMID: 40418155 Objective: To determine whether leptin receptor–expressing neurons in the ventromedial hypothalamus (VMH) contribute to the initial overconsumption of a high-fat diet in rats. Summary: Ablation of
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Product Disease Model 192-IgG-SAP (Cat. #IT-01) Alzheimer’s Disease Acetylated LDL-SAP (Cat. #IT-08) Alzheimer’s Disease Anti-ChAT-SAP (Cat. #IT-42) Alzheimer’s Disease, Down syndrome, Rett syndrome Anti-DAT-SAP (Cat. #IT-25) Parkinson’s Disease Anti-DBH-SAP (Cat. #IT-03) Alzheimer’s Disease CTB-SAP (Cat. #IT-14) Lou Gehrig’s Disease (Amyotrophic lateral sclerosis, ALS) GAT1-SAP (Cat. #IT-32) Epilepsy Mac-1-SAP mouse/human (Cat. #IT-06) Alzheimer’s Disease ME20.4-SAP (Cat.
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Bai J, Cheng K, Zhang N, Chen Y, Ni J, Wang Z (2025) Research advances in dysphagia animal models. Animal Model Exp Med doi: 10.1002/ame2.70054 PMID: 40566744 Objective: To summarize the establishment and evaluation of dysphagia animal models in stroke, Parkinson’s disease, and ALS, in three kinds of experimental animals, providing a basis for the
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Saporin as the Scalpel The Proxima recently hosted a 2-day joint conference on Dementia, Alzheimer’s and Parkinson’s diseases (DAPD-2025) and Neurodegenerative & Neuromuscular diseases (NND-2025). The hybrid conferences took place in the beautiful city of Barcelona, Spain and online during June 19-20, 2025. As authors of the publication, “Saporin as a Commercial Reagent: Its Uses
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Szysiak N, Kosior-Korzecka U, longo V, Patkowski K, Greguła-Kania M, Nowakiewicz A, Bochniarz M,Junkuszew A (2025) Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res doi: 10.2478/jvetres-2025-0003 Objective: The aim of the study was to analyze the direct effect of