Author name: Kristen Hartman

Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2025) Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning. Blood ICT 1(3):100012. doi: 10.1016/j.bict.2025.100012 PMID: 41574174 Objective: To develop and validate a modular streptavidin based antibody drug conjugate platform for optimizing antibody mediated hematopoietic stem cell transplant conditioning. Summary: The […]

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Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer

Park JS, Kenum C, He L, Khan AG, Pohl MA, White TE, Kodangattil SR, Rudin CM, Balderes PJ, Lorenz IC, Massagué J, anesh K (2025) Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer. bioRxiv 2025.10.01.679843. doi: 10.1101/2025.10.01.679843 PMID: 41256399 Objective: To develop L1CAM-targeted antibody-drug conjugates (ADCs) using high-affinity monoclonal antibodies and assess their

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Progress, opportunity, and perspective on long term preservation of extracellular vesicles

Du R, Zhang Y, Wu S, Zixing W, Jing W (2025) Progress, opportunity, and perspective on long term preservation of extracellular vesicles. SSRN ssrn.5553381. doi: 10.2139/ssrn.5553381 Objective: To provide an overview of the biology, function, and biomedical application of Extracellular vesicles (EVs) and introduce the method to evaluate the storage stability of EVs. Summary: While

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The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice

Gan JH, Wang MJ, Li CY, Huang Y, Liu ZH, Bai WL, Xu WJ, Sun MH, Kang MT, Morgan I, Wang N, Li SM (2025) The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice. Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-025-06950-2 PMID: 41026222

The interplay between form deprivation and dopamine signaling in regulating the expression of circadian rhythm-related genes in the retina of mice Read More »

Cerebellar contributions to spatial learning and memory: Effects of discrete immunotoxic lesions

Leanza MH, Storelli E, D’Arco D, de Leo G, Kleiner G, Arancio L, Capodieci G, Gulino R, Bava A, Leanza G (2025) Cerebellar contributions to spatial learning and memory: Effects of discrete immunotoxic lesions. Int J Mol Sci 26(19):9553. doi: 10.3390/ijms26199553 PMID: 41096819 Objective: To analyze the behavioral and anatomical effects of discrete injections, in

Cerebellar contributions to spatial learning and memory: Effects of discrete immunotoxic lesions Read More »

CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice

Herrerias A, Oliverio A, Dvorácskó S, Thyagarajan A, Chedester L, Liu J, Cinar R, Iyer MR, Kunos G, Godlewski G (2026) CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice. Mol Psychiatry 31(1):48-61. doi: 10.1038/s41380-025-03266-9 PMID: 40975751 Objective: To investigate how peripheral CB1 receptors on vagal afferent neurons regulate

CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice Read More »

Long-term scratching analysis of mice using machine learning

Kobayashi K, Miyazaki Y, Sakamoto N, Yamamoto M, Nagat N, Murata T (2025) Long-term scratching analysis of mice using machine learning. PNAS Nexus 4(9):pgaf292. doi: 10.1093/pnasnexus/pgaf292 PMID: 41030291 Objective: To objectively quantify mouse scratching behavior across light and dark cycles using automated, long-term machine learning analysis. Summary: Naïve BALB/c mice exhibited more frequent and persistent

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Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab

Alampi MM, Kozlíková M, Mariangeli M, Civita S, Delcanale P, Mussini A, Diaspro A, Bianchini P, Weyergang A, Skarpen E, Berg K, Viappiani C, Abbruzzetti S, Selbo PK (2025) Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab. Biomed Pharmacother 191:118550. doi: 10.1016/j.biopha.2025.118550 PMID: 40946581 Objective: To optimize the cytotoxic efficacy of a photoimmunoconjugate

Light-enhanced cytotoxicity and intracellular trafficking of the PD-L1-targeting photoimmunoconjugate EITC-atezolizumab Read More »

Melanopsin Antibody Recent Publications

We’re highlighting one of our antibodies, a rabbit polyclonal against Melanopsin. This antibody is offered as both serum (AB-N38) and affinity purified (AB-N39). Intrinsically photosensitive retinal ganglion cells (ipRGCs) are cells that express melanopsin. These ipRGCs, with their long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Our

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Focal irradiation regulates distal neural stem and progenitor cell behaviour

Handfield J (2025) Focal irradiation regulates distal neural stem and progenitor cell behaviour. Univ Toronto Thesis. Objective: To investigate how focal irradiation (IR) impacts non-irradiated neural stem cell (NSC) niches along the neuraxis and whether microglia mediate these long-distance effects. Summary: Focal cranial IR decreased spinal cord-derived NSCs, while spinal IR reduced neuroblasts and NSCs

Focal irradiation regulates distal neural stem and progenitor cell behaviour Read More »

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