Author name: Kristen Hartman

Nociception and acute pain: Neurotransmitters and neuromodulators

Windhorst U, Dibaj P (2025) Nociception and acute pain: Neurotransmitters and neuromodulators. Preprints.org preprints202508.0487.v1. doi: 10.20944/preprints202508.0487.v1 Objective: To review the huge variety of additional neurotransmitters, neuromodulators and hormones in the nociceptive and pain system Summary: Nociception and acute pain are governed by a dynamic interplay of structures and substances, modulated by internal and external factors, […]

Nociception and acute pain: Neurotransmitters and neuromodulators Read More »

The pharmacotherapeutic potential of neuropeptide Y for chronic pain

Nie AA, Taylor BK (2025) The pharmacotherapeutic potential of neuropeptide Y for chronic pain. J Intern Med 298(4):280-896. doi: 10.1111/joim.20118 PMID: 40754889 Objective: To evaluate how neuropeptide Y (NPY) and its receptor subtypes (Y1 and Y2) regulate acute and chronic pain, and to explore the therapeutic potential of targeting these pathways for the treatment of

The pharmacotherapeutic potential of neuropeptide Y for chronic pain Read More »

Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement

Pandala N, De Melo Haefeli L, Lang M, Stone EM, Mullins RF, Tucker BA, Han IC (2025) Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement. bioRxiv 2025.07.29.667466. doi: 10.1101/2025.07.29.667466 PMID: 40766580 Objective: To report a new targeted choroidal injury model using saporin conjugates and compare them

Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement Read More »

Programmable protein ligation on cell surfaces

Kofoed C, Erkalo G, Tay NES, Ye X, Lin Y, Muir TW (2025) Programmable protein ligation on cell surfaces. Nature 10.1038/s41586-025-09287-2. doi: 10.1038/s41586-025-09287-2 PMID: 40739351 Objective: To describe an autonomous decision-making device driven by proximity-gated protein trans-splicing that allows local generation of an active protein from two otherwise inactive polypeptide fragments Summary: Authors showed that

Programmable protein ligation on cell surfaces Read More »

Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery

Li Y, Liu J, Yao L, Mao T, Wang X, He Z, Lyu J, Wang W (2025) Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery. JACS Au 5(8):3951-3959. doi: 10.1021/jacsau.5c00592 PMID: 40881396 Objective: To design and develop a new versatile branched poly (β-aminoester) (PAE)-based delivery system by incorporating the synergistic effects

Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery Read More »

Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta)

Nazmuddin M, Stammes MA, Klink PC, Vernes MK, Bakker J, Langermans JAM, van Laar T, Philippens IHCHM (2026) Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta). J Neuropathol Exp Neurol 85(1):58-70. doi: 10.1093/jnen/nlaf081 PMID: 40673943 Objective: To describe a procedure to

Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta) Read More »

Search
Shopping Cart
Scroll to Top