Author name: Kristen Hartman

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats

Orciani C, Foret MK, Cuello AC, Carmo SD (2025) Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats. Neurobiology of Aging 150:132-145. doi: 10.1016/j.neurobiolaging.2025.03.006 PMID: 40121723 Objective: To investigate the effects of the Basal forebrain cholinergic neurons (BFCNs) input on neurovascular unit (NVU) components. Summary: […]

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats Read More »

The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction

Lauer LT, Decarie-Spain L, Hayes AMR, Suarez AN, Bashaw A, Klug ME, Kao AE, Cheng R, Rea JJ, Subramanian KS, Nourbash A, Donohue KN, Schier LA, Myers K, Kanoski SE (2025) The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction. bioRxiv 2025.06.11.659206. Objective: To demonstrate that nutrient consumption promotes hippocampal-dependent memory

The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction Read More »

A systemic clock brake: Period1 stabilizes the circadian network under environmental stress

Kim P, Kumar V, Garner N, Jayasingh O, Roman G, Walters S, Vo T, Nguyen Q, Bowles J, Woodruff T, Inder W, Hunt J, Heyde I, Oster H, Rawashdeh O (2025) A systemic clock brake: Period1 stabilizes the circadian network under environmental stress. bioRxiv 2025.06.12.659230. doi: 10.1101/2025.06.12.659230 Objective: To investigate the role of the core

A systemic clock brake: Period1 stabilizes the circadian network under environmental stress Read More »

CD320 receptor and vitamin B12 as potential targets for anti-cancer therapy

Tolymbekova A, Lezina L (2025) CD320 receptor and vitamin B12 as potential targets for anti-cancer therapy. Int J Mol Sci 26(12):5652. doi: 10.3390/ijms26125652 PMID: 40565117 Objective: To develop therapies discriminating between healthy and cancerous cells to prevent unwanted toxicity of anticancer agents. Summary: One possible method is to target proteins overexpressed in cancer but not

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Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion

Zhu M, Wu Y, Gao H, Qi F, Zhang X, Ran Y (2025) Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion. Commun Biol 8(1):911. doi: 10.1038/s42003-025-08314-2 PMID: 40500296 Objective: To explore why intrinsically photosensitive retinal ganglion cells (ipRGCs) are more resistant to ischemia/reperfusion (I/R) injury than other RGC

Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion Read More »

Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice

Ren X, Wang Y, Zhang Y (2025) Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. Cell Discov 11:56. doi: 10.1038/s41421-025-00810-3 PMID: 40490480 Objective: To develop and evaluate a targeted strategy for depleting dysfunctional, myeloid-biased CD150-high hematopoietic stem cells (HSCs) in aged mice to restore balanced hematopoiesis and mitigate aging-related blood

Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice Read More »

Saporin Conjugates

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Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery ZAP conjugates are non-targeted saporin conjugates that “piggyback” on to your primary targeting agent Controls are a vital part of the scientific procedure. These control conjugates are the same molecular weight, consist of similar, comparable materials and are

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Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy

Movahed AY, Bagheri R, Savatier P, Šarić T, Moradi S (2025) Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy. Stem Cell Reports 102543. doi: 10.1016/j.stemcr.2025.102543 PMID: 40541178 Objective: To review and evaluate current strategies for eliminating tumorigenic pluripotent stem cells (PSCs) from differentiated

Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy Read More »

Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment

Zhang Z, He F, Li W, Liu B, Deng C, Qin X (2025) Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment. J Funct Biomater 16(6):213. doi: 10.3390/jfb16060213 PMID: 40558899 Objective: To examine nanomaterial applications in Osteosarcoma (OS) therapy through a materials science lens, analyzing mechanism specific interventions. The analysis establishes a framework for developing

Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment Read More »

A characterization of mouse retinal ganglion cell types labeled with AAV tools

Son S, Beaudoin DL, Hassan AR, Akpo MS, Ichinose T, Garrett AM (2025) A characterization of mouse retinal ganglion cell types labeled with AAV tools. bioRxiv 2025.06.02.657062. doi: 10.1101/2025.06.02.657062 Objective: To characterize the cell-type specificity and functional diversity of retinal ganglion cells (RGCs) labeled by AAV vectors carrying synthetic promoters ProA13 and ProA27 in the

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