Author name: Kristen Hartman

Focal irradiation regulates distal neural stem and progenitor cell behaviour

Handfield J (2025) Focal irradiation regulates distal neural stem and progenitor cell behaviour. Univ Toronto Thesis. Objective: To investigate how focal irradiation (IR) impacts non-irradiated neural stem cell (NSC) niches along the neuraxis and whether microglia mediate these long-distance effects. Summary: Focal cranial IR decreased spinal cord-derived NSCs, while spinal IR reduced neuroblasts and NSCs […]

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The dual nature of cold: Unraveling the neural circuits for cool sensing and cold allodynia

Hor CC (2025) The dual nature of cold: Unraveling the neural circuits for cool sensing and cold allodynia. Univ Michigan Thesis. Objective: To elucidate the neural mechanisms underlying innocuous cool sensation from the skin to the brain and the spinal circuitry changes that drive cold allodynia under pathological conditions. Summary: The study identified distinct spinal

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Hole in one: CD137-ADC eliminates GVHD

Nierkens S, Lindemans CA (2025) Hole in one: CD137-ADC eliminates GVHD. Blood 146(9):1038-1040. doi: 10.1182/blood.2025029867 PMID: 40875553 Objective: To show that a single dose of CD137-ADC can prevent acute graft-versus-host disease (GVHD) while pre-serving immune reconstitution in a nonhuman primate (NHP) model of stem cell transplantation. Summary: Results showed that animals treated with CD137-ADC exhibited

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Assessing the hematological cancer stem cell landscape to improve immunotherapy clinical decisions

Diamantoudis SC, Miliotou AN, Galatou E, Telliou S, Sideris K, Grigoriadis N, Vizirianakis IS (2025) Assessing the hematological cancer stem cell landscape to improve immunotherapy clinical decisions. Biocell 49(10):1799-1858. doi: 10.32604/biocell.2025.067216 Objective: To combine existing information and clinical evidence to assess and bring to the spotlight targets related to Hematological cancer stem cells (HCSCs) that

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How many antibody molecules can ZAP bind to? What’s the recommended concentration?

Question I am using your Fab-ZAP Human (IT-51) and I want to know how many antibody molecules can a secondary antibody conjugate theoretically bind to? Answer A whole IgG (bivalent) secondary antibody in theory is capable of binding two antigen molecules.  Since our Fab-ZAP conjugates actually use a monovalent secondary antibody, in theory they would

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Meningeal macrophages mask incision pain sensitization in male rats

Kolahdouzan M, Ghazisaeidi S, Tu Y, Muley M, Gambeta E, Salter M (2025) Meningeal macrophages mask incision pain sensitization in male rats. Mol Pain 21. doi: 10.1177/17448069251383593 PMID: 40958149 Objective: To investigate whether CD206+macrophages in the meninges play a role in regulating nociception and pain hypersensitivity. Summary: The results indicate that while CD206+ meningeal macrophages

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The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex

Shang Y, Gan X, Dang Y, Liu J, Liu P (2025) The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex. J Cell Mol Med 29(15):e70794. doi: 10.1111/jcmm.70794 PMID: 40801824 Objective: To furnish a robust theoretical foundation for the prospective utilization of polarity proteins and their complex as cancer markers and therapeutic

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Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain

Yuan M, Zhang L, Zhu H, Xie M (2025) Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain. PLoS One 20(8):e0330207. doi: 10.1371/journal.pone.0330207 PMID: 40811566 Objective: To examine the expression and localization of BDNF and NE neuron-specific proteins in the locus coeruleus (LC) of mice with cancer-induced

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