pHast Conjugates, Fast Tools
episode4
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The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions
Nollet M, Ba W, Soto BA, Yin C, Lignos L, Jovic K, Vyssotski AL, Yustos R, Franks NP, Wisden W (2025) The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions. bioRxiv 2025.07.09.663930. doi: 10.1101/2025.07.09.663930 Objective: To look genetically at
Alternative treatments and potential cures for type 1 diabetes
Peterson D (2025) Alternative treatments and potential cures for type 1 diabetes. SD State Univ Thesis. Objective: To discuss alternative treatment for type one diabetes. Summary: The use of immunological therapies and stem cells differentiated in insulin-like secreting beta cells is at the forefront of therapies aimed at preserving beta cell function and the potential
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Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies
Huang C, Gudlur S, Maricar S, Chen Z, Shebanova A, Sun Y, Saliba V, Xu C, Zou Y, Zhang J, Boujday S, Miserez A (2025) Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies. APL Bioeng 9(3):036101. doi: 10.1063/5.0279643 PMID: 40642324 Objective: To present a solution for intracellular delivery of large molecules
Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review
Ishtiaque S, Ahman S, Farooqui A, Siddiqui MH, Faridi SA (2025) Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review. IJERT 13(6) Objective: To examine innovative multifunctional nanoparticle strategies designed to overcome transporter-mediated efflux mechanism. Summary: Authors analyze nanocarrier platforms enabling targeted co-delivery of chemotherapeutics with transporter inhibitors, gene-silencing approaches
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats
Noble EE, Harris RBS (2025) Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats. Am J Physiol Endocrinol Metab 329(1):E1-E17. doi: 10.1152/ajpendo.00090.2025 PMID: 40418155 Objective: To determine whether leptin receptor–expressing neurons in the ventromedial hypothalamus (VMH) contribute to the initial overconsumption of a high-fat diet in rats. Summary: Ablation of
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Disease-Modeling Saporin Conjugates
Product Disease Model 192-IgG-SAP (Cat. #IT-01) Alzheimer’s Disease Acetylated LDL-SAP (Cat. #IT-08) Alzheimer’s Disease Anti-ChAT-SAP (Cat. #IT-42) Alzheimer’s Disease, Down syndrome, Rett syndrome Anti-DAT-SAP (Cat. #IT-25) Parkinson’s Disease Anti-DBH-SAP (Cat. #IT-03) Alzheimer’s Disease CTB-SAP (Cat. #IT-14) Lou Gehrig’s Disease (Amyotrophic lateral sclerosis, ALS) GAT1-SAP (Cat. #IT-32) Epilepsy Mac-1-SAP mouse/human (Cat. #IT-06) Alzheimer’s Disease ME20.4-SAP (Cat.
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Research advances in dysphagia animal models
Bai J, Cheng K, Zhang N, Chen Y, Ni J, Wang Z (2025) Research advances in dysphagia animal models. Animal Model Exp Med 8(9):1579-1589. doi: 10.1002/ame2.70054 PMID: 40566744 Objective: To summarize the establishment and evaluation of dysphagia animal models in stroke, Parkinson’s disease, and ALS, in three kinds of experimental animals, providing a basis for
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