Yuan M, Zhang L, Zhu H, Xie M (2025) Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain. PLoS One 20(8):e0330207. doi: 10.1371/journal.pone.0330207 PMID: 40811566 Objective: To examine the expression and localization of BDNF and NE neuron-specific proteins in the locus coeruleus (LC) of mice with cancer-induced […]
Park S, Lu GL, Zheng YC, Davison EK, Li Y (2025) Nanoparticle-based delivery strategies for combating drug resistance in cancer therapeutics. Cancers (Basel) 17(16):2628. doi: 10.3390/cancers17162628 PMID: 40867257 Objective: To explore how nanoparticle-based drug delivery systems can address the challenge of resistance to chemotherapy and targeted therapy by improving drug accumulation in tumors, enhancing targeting
Noh M, Corrigan KA, Williams SG, Peirs C, Leone MJ, Headrick DJ, Guvercin M, Lee S, Phan BN, Yeramosu D, Babu S, Brown AR, Van De Weerd R, Zhao X, Dunn RP, Mathys H, Pfenning AR, Seal RP (2025) A molecular and spinal circuit basis for the functional segregation of itch and pain. bioRxiv 2025.07.31.667966.
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Windhorst U, Dibaj P (2025) Nociception and acute pain: Neurotransmitters and neuromodulators. Preprints.org preprints202508.0487.v1. doi: 10.20944/preprints202508.0487.v1 Objective: To review the huge variety of additional neurotransmitters, neuromodulators and hormones in the nociceptive and pain system Summary: Nociception and acute pain are governed by a dynamic interplay of structures and substances, modulated by internal and external factors,
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Nie AA, Taylor BK (2025) The pharmacotherapeutic potential of neuropeptide Y for chronic pain. J Intern Med 298(4):280-896. doi: 10.1111/joim.20118 PMID: 40754889 Objective: To evaluate how neuropeptide Y (NPY) and its receptor subtypes (Y1 and Y2) regulate acute and chronic pain, and to explore the therapeutic potential of targeting these pathways for the treatment of
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Pandala N, De Melo Haefeli L, Lang M, Stone EM, Mullins RF, Tucker BA, Han IC (2025) Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement. bioRxiv 2025.07.29.667466. doi: 10.1101/2025.07.29.667466 PMID: 40766580 Objective: To report a new targeted choroidal injury model using saporin conjugates and compare them
Kofoed C, Erkalo G, Tay NES, Ye X, Lin Y, Muir TW (2025) Programmable protein ligation on cell surfaces. Nature 10.1038/s41586-025-09287-2. doi: 10.1038/s41586-025-09287-2 PMID: 40739351 Objective: To describe an autonomous decision-making device driven by proximity-gated protein trans-splicing that allows local generation of an active protein from two otherwise inactive polypeptide fragments Summary: Authors showed that
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