Hor CC (2025) The dual nature of cold: Unraveling the neural circuits for cool sensing and cold allodynia. Univ Michigan
Objective: To elucidate the neural mechanisms underlying innocuous cool sensation from the skin to the brain and the spinal circuitry changes that drive cold allodynia under pathological conditions.
Summary: The study identified distinct spinal interneuron populations mediating innocuous cool sensation (Trhr⁺ neurons) and cold allodynia (Tac1⁺/Calb1⁺ neurons). Ablation of these neurons demonstrated their modality-specific contributions, with Trhr⁺ interneurons responsible for cool detection and Tac1⁺/Calb1⁺ neurons for pathological cold hypersensitivity, revealing a spinal circuit basis for temperature discrimination and pain plasticity.
Usage: Bombesin-SAP (IT-40) or Blank-SAP (IT-21) was administered intrathecally at a single dose of 400 ng in 10 µL sterile saline to ablate spinal GRPR⁺ neurons involved in thermal and itch processing.
Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21)