Bombesin-SAP [IT-40]

a tool for eliminating cells that express gastrin releasing peptide (GRP) receptor; targeted via bombesin, eliminated via saporin

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SKU: IT-40 Category: Product Size: 25 ug, 100 ug, 250 ug, 1 mg | Conjugate: saporin | Usage: eliminates cells |

Description

Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. Bombesin-SAP specifically targets GRP receptor-positive cells. All other cells are left untouched. Elimination of cells expressing GPR receptor is useful in studying the role of bombesin in itch and eating behaviors.

Bombesin-SAP specifically targets GRP receptor-positive cells.

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