Saporin as the Scalpel The Proxima recently hosted a 2-day joint conference on Dementia, Alzheimer’s and Parkinson’s diseases (DAPD-2025) and Neurodegenerative & Neuromuscular diseases (NND-2025). The hybrid conferences took place in the beautiful city of Barcelona, Spain and online during June 19-20, 2025. As authors of the publication, “Saporin as a Commercial Reagent: Its Uses […]
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Szysiak N, Kosior-Korzecka U, longo V, Patkowski K, Greguła-Kania M, Nowakiewicz A, Bochniarz M,Junkuszew A (2025) Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res 69(1):121-129. doi: 10.2478/jvetres-2025-0003 PMID: 40144066 Objective: The aim of the study was to analyze the
Orciani C, Foret MK, Cuello AC, Carmo SD (2025) Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats. Neurobiology of Aging 150:132-145. doi: 10.1016/j.neurobiolaging.2025.03.006 PMID: 40121723 Objective: To investigate the effects of the Basal forebrain cholinergic neurons (BFCNs) input on neurovascular unit (NVU) components. Summary:
Lauer LT, Decarie-Spain L, Hayes AMR, Suarez AN, Bashaw A, Klug ME, Kao AE, Cheng R, Rea JJ, Subramanian KS, Nourbash A, Donohue KN, Schier LA, Myers K, Kanoski SE (2025) The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction. bioRxiv 2025.06.11.659206. Objective: To demonstrate that nutrient consumption promotes hippocampal-dependent memory
Kim P, Kumar V, Garner N, Jayasingh O, Roman G, Walters S, Vo T, Nguyen Q, Bowles J, Woodruff T, Inder W, Hunt J, Heyde I, Oster H, Rawashdeh O (2025) A systemic clock brake: Period1 stabilizes the circadian network under environmental stress. bioRxiv 2025.06.12.659230. doi: 10.1101/2025.06.12.659230 Objective: To investigate the role of the core
Tolymbekova A, Lezina L (2025) CD320 receptor and vitamin B12 as potential targets for anti-cancer therapy. Int J Mol Sci 26(12):5652. doi: 10.3390/ijms26125652 PMID: 40565117 Objective: To develop therapies discriminating between healthy and cancerous cells to prevent unwanted toxicity of anticancer agents. Summary: One possible method is to target proteins overexpressed in cancer but not
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Zhu M, Wu Y, Gao H, Qi F, Zhang X, Ran Y (2025) Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion. Commun Biol 8(1):911. doi: 10.1038/s42003-025-08314-2 PMID: 40500296 Objective: To explore why intrinsically photosensitive retinal ganglion cells (ipRGCs) are more resistant to ischemia/reperfusion (I/R) injury than other RGC
Ren X, Wang Y, Zhang Y (2025) Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. Cell Discov 11:56. doi: 10.1038/s41421-025-00810-3 PMID: 40490480 Objective: To develop and evaluate a targeted strategy for depleting dysfunctional, myeloid-biased CD150-high hematopoietic stem cells (HSCs) in aged mice to restore balanced hematopoiesis and mitigate aging-related blood
Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery ZAP conjugates are non-targeted saporin conjugates that “piggyback” on to your primary targeting agent Controls are a vital part of the scientific procedure. These control conjugates are the same molecular weight, consist of similar, comparable materials and are
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