A dedicated skin-to-brain circuit for cool sensation in mice
Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21) episode14, episode38
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Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery
Li Y, Liu J, Yao L, Mao T, Wang X, He Z, Lyu J, Wang W (2025) Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery. JACS Au 5(8):3951-3959. doi: 10.1021/jacsau.5c00592 PMID: 40881396 Objective: To design and develop a new versatile branched poly (β-aminoester) (PAE)-based delivery system by incorporating the synergistic effects
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Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta)
Nazmuddin M, Stammes MA, Klink PC, Vernes MK, Bakker J, Langermans JAM, van Laar T, Philippens IHCHM (2026) Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta). J Neuropathol Exp Neurol 85(1):58-70. doi: 10.1093/jnen/nlaf081 PMID: 40673943 Objective: To describe a procedure to
The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions
Nollet M, Ba W, Soto BA, Yin C, Lignos L, Jovic K, Vyssotski AL, Yustos R, Franks NP, Wisden W (2025) The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions. bioRxiv 2025.07.09.663930. doi: 10.1101/2025.07.09.663930 Objective: To look genetically at
Alternative treatments and potential cures for type 1 diabetes
Peterson D (2025) Alternative treatments and potential cures for type 1 diabetes. SD State Univ Thesis. Objective: To discuss alternative treatment for type one diabetes. Summary: The use of immunological therapies and stem cells differentiated in insulin-like secreting beta cells is at the forefront of therapies aimed at preserving beta cell function and the potential
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Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies
Huang C, Gudlur S, Maricar S, Chen Z, Shebanova A, Sun Y, Saliba V, Xu C, Zou Y, Zhang J, Boujday S, Miserez A (2025) Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies. APL Bioeng 9(3):036101. doi: 10.1063/5.0279643 PMID: 40642324 Objective: To present a solution for intracellular delivery of large molecules
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats
Noble EE, Harris RBS (2025) Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats. Am J Physiol Endocrinol Metab 329(1):E1-E17. doi: 10.1152/ajpendo.00090.2025 PMID: 40418155 Objective: To determine whether leptin receptor–expressing neurons in the ventromedial hypothalamus (VMH) contribute to the initial overconsumption of a high-fat diet in rats. Summary: Ablation of
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