What to know about Custom Biotinylation Service
episode7, episode31
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The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Nie AA, Taylor BK (2025) The pharmacotherapeutic potential of neuropeptide Y for chronic pain. J Intern Med 298(4):280-896. doi: 10.1111/joim.20118 PMID: 40754889 Objective: To evaluate how neuropeptide Y (NPY) and its receptor subtypes (Y1 and Y2) regulate acute and chronic pain, and to explore the therapeutic potential of targeting these pathways for the treatment of
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Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement
Pandala N, De Melo Haefeli L, Lang M, Stone EM, Mullins RF, Tucker BA, Han IC (2025) Development of a targeted choroidal injury model for the study of retinal degenerations and therapeutic cell replacement. bioRxiv 2025.07.29.667466. doi: 10.1101/2025.07.29.667466 PMID: 40766580 Objective: To report a new targeted choroidal injury model using saporin conjugates and compare them
Programmable protein ligation on cell surfaces
Kofoed C, Erkalo G, Tay NES, Ye X, Lin Y, Muir TW (2025) Programmable protein ligation on cell surfaces. Nature 10.1038/s41586-025-09287-2. doi: 10.1038/s41586-025-09287-2 PMID: 40739351 Objective: To describe an autonomous decision-making device driven by proximity-gated protein trans-splicing that allows local generation of an active protein from two otherwise inactive polypeptide fragments Summary: Authors showed that
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A dedicated skin-to-brain circuit for cool sensation in mice
Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21) episode14, episode38
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Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery
Li Y, Liu J, Yao L, Mao T, Wang X, He Z, Lyu J, Wang W (2025) Synergistic effect of guanidinium and tertiary amine groups on boosting gene delivery. JACS Au 5(8):3951-3959. doi: 10.1021/jacsau.5c00592 PMID: 40881396 Objective: To design and develop a new versatile branched poly (β-aminoester) (PAE)-based delivery system by incorporating the synergistic effects
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Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta)
Nazmuddin M, Stammes MA, Klink PC, Vernes MK, Bakker J, Langermans JAM, van Laar T, Philippens IHCHM (2026) Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta). J Neuropathol Exp Neurol 85(1):58-70. doi: 10.1093/jnen/nlaf081 PMID: 40673943 Objective: To describe a procedure to