Author name: Kristen Hartman

Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy

Movahed AY, Bagheri R, Savatier P, Šarić T, Moradi S (2025) Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy. Stem Cell Reports 102543. doi: 10.1016/j.stemcr.2025.102543 PMID: 40541178 Objective: To review and evaluate current strategies for eliminating tumorigenic pluripotent stem cells (PSCs) from differentiated […]

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Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment

Zhang Z, He F, Li W, Liu B, Deng C, Qin X (2025) Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment. J Funct Biomater 16(6):213. doi: 10.3390/jfb16060213 PMID: 40558899 Objective: To examine nanomaterial applications in Osteosarcoma (OS) therapy through a materials science lens, analyzing mechanism specific interventions. The analysis establishes a framework for developing

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A characterization of mouse retinal ganglion cell types labeled with AAV tools

Son S, Beaudoin DL, Hassan AR, Akpo MS, Ichinose T, Garrett AM (2025) A characterization of mouse retinal ganglion cell types labeled with AAV tools. bioRxiv 2025.06.02.657062. doi: 10.1101/2025.06.02.657062 Objective: To characterize the cell-type specificity and functional diversity of retinal ganglion cells (RGCs) labeled by AAV vectors carrying synthetic promoters ProA13 and ProA27 in the

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A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Konturek-Ciesla A, Zhang Q, Kharazi S, Bryder D (2025) A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice. Nat Commun 16(1):5129. doi: 10.1038/s41467-025-60464-3 PMID: 40456713 Objective: Application of Hematopoietic stem cell (HSC) transplantation leads to treatment toxicity. Therefore, authors employed a murine transplantation model based on low-intensity conditioning protocols using

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Neural mechanisms of context-sensitive behavior in the adult male zebra finch

Anderson KL (2025) Neural mechanisms of context-sensitive behavior in the adult male zebra finch. City Univ NY Thesis. Objective: To test whether oxytocin and dopamine mediate the influence of the social behavior network on the vocal control network in songbirds, enabling context-dependent changes to song. Summary: The study reveals direct anatomical links between hypothalamic nodes

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bTRM control of murine cytomegalovirus cns reactivation

Chauhan P, Hu S, Sheng WS, Prasad S, Lokensgard JR (2025) bTRM control of murine cytomegalovirus cns reactivation. 26(11):5275. doi: 10.3390/ijms26115275 PMID: 40508083 Objective: To determine the role of CD8+ and CD103+ brain-resident memory T cells (bTRMs) in controlling murine cytomegalovirus (MCMV) reactivation in the central nervous system. Summary: Depleting CD103+ bTRMs led to transient

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Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform

McLeod CM, Son S, Haque MN, Garrett AM (2025) Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform. bioRxiv 2025.05.29.656828. doi: 10.1101/2025.05.29.656828 PMID: 40502005 Objective: To determine whether the γC4 isoform of the protocadherin-γ (Pcdhg) gene cluster is sufficient to mediate neuronal self-avoidance in starburst amacrine cells (SACs) in the mouse

Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform Read More »

Differentiation of brain mural cells from human pluripotent stem cell-derived neural crest by activation of notch3 signaling

Gastfriend BD, Palecek SP, Shusta EV (2025) Differentiation of brain mural cells from human pluripotent stem cell-derived neural crest by activation of notch3 signaling. (eds. Barichello, T.). Blood-Brain Barrier 221:11-35. Humana, New York, NY. doi: 10.1007/978-1-0716-4474-4_2 Objective: To describe a serum-free method to differentiate brain mural cells from human pluripotent stem cells (hPSCs), using lentiviral

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Enteropancreatic neurons drive the glucoregulatory response to ingested lipid

Roberts AG, Meyer L, Norton M, Phuah P, Alonso AM, Dowsett GKC, Cheng S, Dunsterville C, Liu J, Chung PE, Tao Y, Smitherman-Cairns T, Deutsch AB, Chatterjee A, Lam BYH, Hanyaloglu AC, Jones B, Yeo GSH, Salem V, Murphy KG (2025) Enteropancreatic neurons drive the glucoregulatory response to ingested lipid. bioRxiv 2025.05.09.652620. doi: 10.1101/2025.05.09.652620 Objective:

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Magnetic fields influence visual responses in mice

Semo M, Hughes S, Smyllie NJ, Patton AP, Pothecary CA, Tam SKE, Buckland J, Brown LA (2025) Magnetic fields influence visual responses in mice. bioRxiv 2025.05.12.653455. doi: 10.1101/2025.05.12.653455 Objective: To investigate whether magnetic fields influence mammalian retinal function and to determine the role of cryptochromes in mediating this effect. Summary: This study demonstrates that magnetic

Magnetic fields influence visual responses in mice Read More »

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