Author name: Kristen Hartman

Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review

Ishtiaque S, Ahman S, Farooqui A, Siddiqui MH, Faridi SA (2025) Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review. IJERT 13(6) Objective: To examine innovative multifunctional nanoparticle strategies designed to overcome transporter-mediated efflux mechanism. Summary: Authors analyze nanocarrier platforms enabling targeted co-delivery of chemotherapeutics with transporter inhibitors, gene-silencing approaches […]

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Disease-Modeling Saporin Conjugates

Uncategorized /

Product Disease Model 192-IgG-SAP (Cat. #IT-01) Alzheimer’s Disease Acetylated LDL-SAP (Cat. #IT-08) Alzheimer’s Disease Anti-ChAT-SAP (Cat. #IT-42) Alzheimer’s Disease, Down syndrome, Rett syndrome Anti-DAT-SAP (Cat. #IT-25) Parkinson’s Disease Anti-DBH-SAP (Cat. #IT-03) Alzheimer’s Disease CTB-SAP (Cat. #IT-14) Lou Gehrig’s Disease (Amyotrophic lateral sclerosis, ALS) GAT1-SAP (Cat. #IT-32) Epilepsy Mac-1-SAP mouse/human (Cat. #IT-06) Alzheimer’s Disease ME20.4-SAP (Cat.

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Saporin as the Scalpel

News Article, Video /

Saporin as the Scalpel The Proxima recently hosted a 2-day joint conference on Dementia, Alzheimer’s and Parkinson’s diseases (DAPD-2025) and Neurodegenerative & Neuromuscular diseases (NND-2025).  The hybrid conferences took place in the beautiful city of Barcelona, Spain and online during June 19-20, 2025.   As authors of the publication, “Saporin as a Commercial Reagent: Its Uses

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Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes

Szysiak N, Kosior-Korzecka U, longo V, Patkowski K, Greguła-Kania M, Nowakiewicz A, Bochniarz M,Junkuszew A (2025) Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res 69(1):121-129. doi: 10.2478/jvetres-2025-0003 PMID: 40144066 Objective: The aim of the study was to analyze the

Influence of neurokinin b, dynorphin a and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes Read More »

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats

Orciani C, Foret MK, Cuello AC, Carmo SD (2025) Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats. Neurobiology of Aging 150:132-145. doi: 10.1016/j.neurobiolaging.2025.03.006 PMID: 40121723 Objective: To investigate the effects of the Basal forebrain cholinergic neurons (BFCNs) input on neurovascular unit (NVU) components. Summary:

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats Read More »

The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction

Lauer LT, Decarie-Spain L, Hayes AMR, Suarez AN, Bashaw A, Klug ME, Kao AE, Cheng R, Rea JJ, Subramanian KS, Nourbash A, Donohue KN, Schier LA, Myers K, Kanoski SE (2025) The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction. bioRxiv 2025.06.11.659206. Objective: To demonstrate that nutrient consumption promotes hippocampal-dependent memory

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A systemic clock brake: Period1 stabilizes the circadian network under environmental stress

Kim P, Kumar V, Garner N, Jayasingh O, Roman G, Walters S, Vo T, Nguyen Q, Bowles J, Woodruff T, Inder W, Hunt J, Heyde I, Oster H, Rawashdeh O (2025) A systemic clock brake: Period1 stabilizes the circadian network under environmental stress. bioRxiv 2025.06.12.659230. doi: 10.1101/2025.06.12.659230 Objective: To investigate the role of the core

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