Author name: Kristen Hartman

The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions

Nollet M, Ba W, Soto BA, Yin C, Lignos L, Jovic K, Vyssotski AL, Yustos R, Franks NP, Wisden W (2025) The selective amyloid-driven failure of cholinergic medial septal neurons in aging mice perturbs REM sleep, cognition and emotion, and broadcasts amyloid to other brain regions. bioRxiv 2025.07.09.663930. doi: 10.1101/2025.07.09.663930 Objective: To look genetically at […]

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Alternative treatments and potential cures for type 1 diabetes

Peterson D (2025) Alternative treatments and potential cures for type 1 diabetes. SD State Univ Thesis. Objective: To discuss alternative treatment for type one diabetes. Summary: The use of immunological therapies and stem cells differentiated in insulin-like secreting beta cells is at the forefront of therapies aimed at preserving beta cell function and the potential

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Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies

Huang C, Gudlur S, Maricar S, Chen Z, Shebanova A, Sun Y, Saliba V, Xu C, Zou Y, Zhang J, Boujday S, Miserez A (2025) Peptide coacervates as intracellular delivery vehicles for synergistic cancer photothermal- and chemo-therapies. APL Bioeng 9(3):036101. doi: 10.1063/5.0279643 PMID: 40642324 Objective: To present a solution for intracellular delivery of large molecules

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Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review

Ishtiaque S, Ahman S, Farooqui A, Siddiqui MH, Faridi SA (2025) Multifunctional nanoparticles to over come ABC transporter-mediated drug resistance in cancer: A short review. IJERT 13(6) Objective: To examine innovative multifunctional nanoparticle strategies designed to overcome transporter-mediated efflux mechanism. Summary: Authors analyze nanocarrier platforms enabling targeted co-delivery of chemotherapeutics with transporter inhibitors, gene-silencing approaches

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Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats

Noble EE, Harris RBS (2025) Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats. Am J Physiol Endocrinol Metab 329(1):E1-E17. doi: 10.1152/ajpendo.00090.2025 PMID: 40418155 Objective: To determine whether leptin receptor–expressing neurons in the ventromedial hypothalamus (VMH) contribute to the initial overconsumption of a high-fat diet in rats. Summary: Ablation of

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Disease-Modeling Saporin Conjugates

Uncategorized /

Product Disease Model 192-IgG-SAP (Cat. #IT-01) Alzheimer’s Disease Acetylated LDL-SAP (Cat. #IT-08) Alzheimer’s Disease Anti-ChAT-SAP (Cat. #IT-42) Alzheimer’s Disease, Down syndrome, Rett syndrome Anti-DAT-SAP (Cat. #IT-25) Parkinson’s Disease Anti-DBH-SAP (Cat. #IT-03) Alzheimer’s Disease CTB-SAP (Cat. #IT-14) Lou Gehrig’s Disease (Amyotrophic lateral sclerosis, ALS) GAT1-SAP (Cat. #IT-32) Epilepsy Mac-1-SAP mouse/human (Cat. #IT-06) Alzheimer’s Disease ME20.4-SAP (Cat.

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Saporin as the Scalpel

News Article, Video /

Saporin as the Scalpel The Proxima recently hosted a 2-day joint conference on Dementia, Alzheimer’s and Parkinson’s diseases (DAPD-2025) and Neurodegenerative & Neuromuscular diseases (NND-2025).  The hybrid conferences took place in the beautiful city of Barcelona, Spain and online during June 19-20, 2025.   As authors of the publication, “Saporin as a Commercial Reagent: Its Uses

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