Bai J, Cheng K, Zhang N, Chen Y, Ni J, Wang Z (2025) Research advances in dysphagia animal models. Animal Model Exp Med doi: 10.1002/ame2.70054 PMID: 40566744
Objective: To summarize the establishment and evaluation of dysphagia animal models in stroke, Parkinson’s disease, and ALS, in three kinds of experimental animals, providing a basis for the selection of appropriate animal models of dysphagia.
Summary: There are very few studies of diseases such as stroke, PD, and ALS using other mammal and NHP dysphagia models. Moreover, there are substantial labor, cost, time, and ethics-related issues that limit the widespread use of these animal models in research. Nevertheless, large animal models serve as a crucial intermediary between rodent studies and clinical trials, significantly enhancing the translational potential of preclinical research findings.
Usage: Lori et al. used an ALS model created by intralingual injection of cholera toxin B conjugated to saporin (CTB-SAP) to induce apoptosis of sublingual motoneurons to study the effect of hypoglossal motor neuron death without many complications.
Related Products: CTB-SAP (Cat. #IT-14)
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