Author name: Kristen Hartman

CD320 receptor and vitamin B12 as potential targets for anti-cancer therapy

Tolymbekova A, Lezina L (2025) CD320 receptor and vitamin B12 as potential targets for anti-cancer therapy. Int J Mol Sci 26(12):5652. doi: 10.3390/ijms26125652 PMID: 40565117 Objective: To develop therapies discriminating between healthy and cancerous cells to prevent unwanted toxicity of anticancer agents. Summary: One possible method is to target proteins overexpressed in cancer but not […]

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Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion

Zhu M, Wu Y, Gao H, Qi F, Zhang X, Ran Y (2025) Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion. Commun Biol 8(1):911. doi: 10.1038/s42003-025-08314-2 PMID: 40500296 Objective: To explore why intrinsically photosensitive retinal ganglion cells (ipRGCs) are more resistant to ischemia/reperfusion (I/R) injury than other RGC

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Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice

Ren X, Wang Y, Zhang Y (2025) Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. Cell Discov 11:56. doi: 10.1038/s41421-025-00810-3 PMID: 40490480 Objective: To develop and evaluate a targeted strategy for depleting dysfunctional, myeloid-biased CD150-high hematopoietic stem cells (HSCs) in aged mice to restore balanced hematopoiesis and mitigate aging-related blood

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Saporin Conjugates

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Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery ZAP conjugates are non-targeted saporin conjugates that “piggyback” on to your primary targeting agent Controls are a vital part of the scientific procedure. These control conjugates are the same molecular weight, consist of similar, comparable materials and are

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Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy

Movahed AY, Bagheri R, Savatier P, Šarić T, Moradi S (2025) Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy. Stem Cell Reports 102543. doi: 10.1016/j.stemcr.2025.102543 PMID: 40541178 Objective: To review and evaluate current strategies for eliminating tumorigenic pluripotent stem cells (PSCs) from differentiated

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Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment

Zhang Z, He F, Li W, Liu B, Deng C, Qin X (2025) Material-driven therapeutics: Functional nanomaterial design paradigms revolutionizing osteosarcoma treatment. J Funct Biomater 16(6):213. doi: 10.3390/jfb16060213 PMID: 40558899 Objective: To examine nanomaterial applications in Osteosarcoma (OS) therapy through a materials science lens, analyzing mechanism specific interventions. The analysis establishes a framework for developing

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A characterization of mouse retinal ganglion cell types labeled with AAV tools

Son S, Beaudoin DL, Hassan AR, Akpo MS, Ichinose T, Garrett AM (2025) A characterization of mouse retinal ganglion cell types labeled with AAV tools. bioRxiv 2025.06.02.657062. doi: 10.1101/2025.06.02.657062 Objective: To characterize the cell-type specificity and functional diversity of retinal ganglion cells (RGCs) labeled by AAV vectors carrying synthetic promoters ProA13 and ProA27 in the

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A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Konturek-Ciesla A, Zhang Q, Kharazi S, Bryder D (2025) A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice. Nat Commun 16(1):5129. doi: 10.1038/s41467-025-60464-3 PMID: 40456713 Objective: Application of Hematopoietic stem cell (HSC) transplantation leads to treatment toxicity. Therefore, authors employed a murine transplantation model based on low-intensity conditioning protocols using

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Neural mechanisms of context-sensitive behavior in the adult male zebra finch

Anderson KL (2025) Neural mechanisms of context-sensitive behavior in the adult male zebra finch. City Univ NY Thesis. Objective: To test whether oxytocin and dopamine mediate the influence of the social behavior network on the vocal control network in songbirds, enabling context-dependent changes to song. Summary: The study reveals direct anatomical links between hypothalamic nodes

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Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform

McLeod CM, Son S, Haque MN, Garrett AM (2025) Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform. bioRxiv 2025.05.29.656828. doi: 10.1101/2025.05.29.656828 PMID: 40502005 Objective: To determine whether the γC4 isoform of the protocadherin-γ (Pcdhg) gene cluster is sufficient to mediate neuronal self-avoidance in starburst amacrine cells (SACs) in the mouse

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