Hung LY, Alves ND, Del Colle A, Talati A, Najjar SA, Bouchard V, Gillet V, Tong Y, Huang Z, Browning KN, Hua J, Liu Y, Woodruff JO, Juarez D, Medina M, Posner J, Tonello R, Yalcinkaya N, Israelyan N, Ringel R, Yang L, Leong KW, Yang M, Sze JY, Savidge T, Gingrich J, Shulman RJ, […]
Ren L, Zhao Z, Chao Y, Yu P, Mei Z, Du B, Cheng Y (2025) Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy. Adv Sci (Weinh) e2500844. doi: 10.1002/advs.202500844 PMID: 40056044 Objective: To develop a family of Lipid Nanoparticles (LNPs) with robust high efficiency in addressing
Guo S, Xu H, Cheng Z, Wang L, Yang P, Wang R (2025) Efficient cytosolic delivery of protein by preorganized amidiniums on pillar[5]arene. CCL 111022. doi: 10.1016/j.cclet.2025.111022 Objective: To use amidinium functionalized pillar[5]arene (AP5) as a small molecular carrier to facilitate intracellular delivery of proteins with different sizes and isoelectric points. Summary: The densely preorganized
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Griesgraber MJ, Coolen LM, Onslow KM, Corey JR, Rice RE, Aerts EG, Bowdridge EC, Hardy SL, Lehman MN, Goodman RL, Hileman SM (2025) Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge. J Neuroendocrinol e70010. doi: 10.1111/jne.70010 PMID: 40033679 Objective: To examine the functional role of arcuate nucleus
Saavedra FM, Brotto DB, Joag V, Matson CA, Nesmiyanov PP, Herzberg MC, Vezys V, Masopust D, Stolley JM (2025) Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis. Mucosal Immunol S1933-0219(25)00021-2. doi: 10.1016/j.mucimm.2025.02.003 PMID: 39988203 Objective: To determine if local reactivation of antigen-specific oral CD8+ TRM exacerbates ligature-induced periodontitis (LIP) in mice. Summary: Topical application
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Prince C, Kumar D, Chambliss C, Okalava J, Malik S, Doering CB, Spencer HT, Archer D. Chandrakasan S (2025) Clinically relevant non-genotoxic conditioning with cd117 immunotoxin promotes robust donor chimerism and amelioration of sickle cell disease in a murine model. Transplantation and Cellular Therapy 31(2):S178. doi: 10.1016/j.jtct.2025.01.274 Objective: To investigate the efficacy of an Anti-CD117-Saporin
Dib C, Queenan J, Willner H, Swartzrock L, Charlesworth C, Denis M, Davis J, Nakauchi H, Liu DR (2025) Combining hsc base-editing with anti-cd117 antibody conditioning to correct severe combined immunodeficiency disorder in a novel mouse model. Transplantation and Cellular Therapy 31(2):S253-S354. doi: 10.1016/j.jtct.2025.01.385 Objective: To test whether base-edited hematopoietic stem cells (HSPCs) combined with
Bohl JM, Hassan AR, Sharpe ZJ, Kola M, Shehu A, Beaudoin DL, Ichinose T (2025) Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions. 19:1547066. doi: 10.3389/fncel.2025.1547066 PMID: 39990971 Objective: To examine the roles of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the pupillary light reflex (PLR) by ablating
García-Domínguez M (2025) NGF in neuropathic pain: Understanding its role and therapeutic opportunities. Curr Issues Mol Biol 47(2):93. doi: 10.3390/cimb47020093 PMID: 39996814 Objective: To determine the use of NGF as an important biomarker and therapeutic target in the management of neuropathic pain Summary: Taking advantage of the multifaceted dynamics of NGF could provide effective pain
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Turner KL, Brockway DF, Hossain MdS, Griffith KR, Greenwalt DI, Zhang Q, gheres KW, Crowley NA, Drew PJ (2025) type-I nNOS neurons orchestrate cortical neural activity and vasomotion. bioRxiv 2025.01.21.634042. doi: 10.1101/2025.01.21.634042 PMID: 39896560 Objective: To uncover the role of a sparse but unusual population of genetically-distinct interneurons known as type-I nNOS neurons, using a
type-I nNOS neurons orchestrate cortical neural activity and vasomotion Read More »