Burd E, Attari M, Smith C, Bunyak F, Lever, T, Nichols N (2025) Genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.0879 Objective: To develop a novel rodent model using intralingual injections of cholera toxin B conjugated to saporin (CTB-SAP) to induce targeted loss […]
Oti GO, Basak A, Eason G, Kington S, Drago C, Smith L, Osman K, Smith CL, Keilholz A, Lever TE, Nichols NL (2025) Therapeutic potential of tongue exercise on tongue force/strength during swallowing in a rodent model of hypoglossal (xii) motor neuron loss. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.1188 Objective: To develop a rodent model
Lewis R, Smith C, Burd E, Nichols N (2025) Phrenic motor nucleus astrocytic density and morphology in a rodent model of respiratory motor neuron death. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.1115 Objective: Authors hypothesized that astrocytic density would be increased and astrocytic morphology would be altered in the phrenic motor nucleus over the course of
Janes TA, Parra Sanchez AS, Cardani S, Pagliardini S (2025) Progestin infusion into the hypothalamus of CO2-chemoreflex impaired female rats enhances the hypercapnic ventilatory response. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.1430 Objective: Authors hypothesized that etonogestrel (ETO) infusion into the dorsomedial hypothalamus (DMH) would elicit CO2-chemo reflex recovery similar to that observed in systemically treated
Keilholz A, Henry J, Osman K, Smith C, Haxton C, Ozden I, Lever T, Nichols N (2025) Impact of TrkB receptor modulation on tongue exercise-induced plasticity in an inducible rodent model of hypoglossal (xii) motor neuron death. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.0788 Objective: Authors hypothesized that the source of tongue exercise-induced plasticity in CTB-SAP
Kozlova E, Lam A, Alam S, Shum J, Denys M, Berdasco C, de-Lartigue G, Curras-Collazo M (2025) Do CCKA receptor containing vagal afferent neurons mediate gut-brain inflammatory signals?. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.2035 Objective: To investigate whether CCKA receptor, containing vagal afferent neurons (VANs), mediate gut-brain inflammatory signaling and contribute to the systemic immune
Shibata Y, Matsumoto Y, Kohno K, Nakashima Y, Tsuda M (2025) Microgliosis in the spinal dorsal horn early after peripheral nerve injury is associated with damage to primary afferent aβ-fibers. Cells 14(9):666. doi: 10.3390/cells14090666 PMID: 40358190 Objective: To investigate the spatial relationship between microgliosis and the projections of injured nerves by generating mice that had
Kiyama T, Chen CK, Altay HY, Chen YJ, Sigala L, Su D, Eliason S, Amendt BA, Mao CA (2025) Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. bioRxiv 2025.04.29.651262. doi: 10.1101/2025.04.29.651262 PMID: 40654872 Objective: To demonstrate that two Tbr2-dependent transcription factors, Iroquois‑related homeobox 1 (Irx1) and T-box containing factor 20 (Tbx20), are key
Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes Read More »
Question: We have been using your human fab-pHast (PH-01) product for a while now and are very happy with the results in our imaging applications (we have seen signal to noise of over 70k). However I have recently tried running a black bottom plate on a plate reader, same set up, and am getting a
Fab-pHast background signal with black-bottom plates Read More »
Hung LY, Alves ND, Del Colle A, Talati A, Najjar SA, Bouchard V, Gillet V, Tong Y, Huang Z, Browning KN, Hua J, Liu Y, Woodruff JO, Juarez D, Medina M, Posner J, Tonello R, Yalcinkaya N, Israelyan N, Ringel R, Yang L, Leong KW, Yang M, Sze JY, Savidge T, Gingrich J, Shulman RJ,