Author name: Kristen Hartman

Progestin infusion into the hypothalamus of CO2-chemoreflex impaired female rats enhances the hypercapnic ventilatory response

Janes TA, Parra Sanchez AS, Cardani S, Pagliardini S (2025) Progestin infusion into the hypothalamus of CO2-chemoreflex impaired female rats enhances the hypercapnic ventilatory response. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.1430 Objective: Authors hypothesized that etonogestrel (ETO) infusion into the dorsomedial hypothalamus (DMH) would elicit CO2-chemo reflex recovery similar to that observed in systemically treated […]

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Do CCKA receptor containing vagal afferent neurons mediate gut-brain inflammatory signals?

Kozlova E, Lam A, Alam S, Shum J, Denys M, Berdasco C, de-Lartigue G, Curras-Collazo M (2025) Do CCKA receptor containing vagal afferent neurons mediate gut-brain inflammatory signals?. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.2035 Objective: To investigate whether CCKA receptor, containing vagal afferent neurons (VANs), mediate gut-brain inflammatory signaling and contribute to the systemic immune

Do CCKA receptor containing vagal afferent neurons mediate gut-brain inflammatory signals? Read More »

Genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death

Burd E, Attari M, Smith C, Bunyak F, Lever, T, Nichols N (2025) Genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.0879 Objective: To develop a novel rodent model using intralingual injections of cholera toxin B conjugated to saporin (CTB-SAP) to induce targeted loss

Genioglossus sarcomere and mitochondria morphology in a rodent model of hypoglossal motor neuron death Read More »

Microgliosis in the spinal dorsal horn early after peripheral nerve injury is associated with damage to primary afferent aβ-fibers

Shibata Y, Matsumoto Y, Kohno K, Nakashima Y, Tsuda M (2025) Microgliosis in the spinal dorsal horn early after peripheral nerve injury is associated with damage to primary afferent aβ-fibers. Cells 14(9):666. doi: 10.3390/cells14090666 PMID: 40358190 Objective: To investigate the spatial relationship between microgliosis and the projections of injured nerves by generating mice that had

Microgliosis in the spinal dorsal horn early after peripheral nerve injury is associated with damage to primary afferent aβ-fibers Read More »

Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes

Kiyama T, Chen CK, Altay HY, Chen YJ, Sigala L, Su D, Eliason S, Amendt BA, Mao CA (2025) Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. bioRxiv 2025.04.29.651262. doi: 10.1101/2025.04.29.651262 PMID: 40654872 Objective: To demonstrate that two Tbr2-dependent transcription factors, Iroquois‑related homeobox 1 (Irx1) and T-box containing factor 20 (Tbx20), are key

Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes Read More »

Intestinal epithelial serotonin as a novel target for treating disorders of gut-brain interaction and mood

Hung LY, Alves ND, Del Colle A, Talati A, Najjar SA, Bouchard V, Gillet V, Tong Y, Huang Z, Browning KN, Hua J, Liu Y, Woodruff JO, Juarez D, Medina M, Posner J, Tonello R, Yalcinkaya N, Israelyan N, Ringel R, Yang L, Leong KW, Yang M, Sze JY, Savidge T, Gingrich J, Shulman RJ,

Intestinal epithelial serotonin as a novel target for treating disorders of gut-brain interaction and mood Read More »

Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy

Ren L, Zhao Z, Chao Y, Yu P, Mei Z, Du B, Cheng Y (2025) Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy. Adv Sci (Weinh) e2500844. doi: 10.1002/advs.202500844 PMID: 40056044 Objective: To develop a family of Lipid Nanoparticles (LNPs) with robust high efficiency in addressing

Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy Read More »

Efficient cytosolic delivery of protein by preorganized amidiniums on pillar[5]arene

Guo S, Xu H, Cheng Z, Wang L, Yang P, Wang R (2025) Efficient cytosolic delivery of protein by preorganized amidiniums on pillar[5]arene. CCL 111022. doi: 10.1016/j.cclet.2025.111022 Objective: To use amidinium functionalized pillar[5]arene (AP5) as a small molecular carrier to facilitate intracellular delivery of proteins with different sizes and isoelectric points. Summary: The densely preorganized

Efficient cytosolic delivery of protein by preorganized amidiniums on pillar[5]arene Read More »

Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge

Griesgraber MJ, Coolen LM, Onslow KM, Corey JR, Rice RE, Aerts EG, Bowdridge EC, Hardy SL, Lehman MN, Goodman RL, Hileman SM (2025) Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge. J Neuroendocrinol e70010. doi: 10.1111/jne.70010 PMID: 40033679 Objective: To examine the functional role of arcuate nucleus

Critical role of arcuate nucleus kisspeptin and Kiss1R in regulation of the ovine luteinizing hormone surge Read More »

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