Author name: Kristen Hartman

Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis

Saavedra FM, Brotto DB, Joag V, Matson CA, Nesmiyanov PP, Herzberg MC, Vezys V, Masopust D, Stolley JM (2025) Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis. Mucosal Immunol S1933-0219(25)00021-2. doi: 10.1016/j.mucimm.2025.02.003 PMID: 39988203 Objective: To determine if local reactivation of antigen-specific oral CD8+ TRM exacerbates ligature-induced periodontitis (LIP) in mice. Summary: Topical application […]

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Clinically relevant non-genotoxic conditioning with cd117 immunotoxin promotes robust donor chimerism and amelioration of sickle cell disease in a murine model

Prince C, Kumar D, Chambliss C, Okalava J, Malik S, Doering CB, Spencer HT, Archer D. Chandrakasan S (2025) Clinically relevant non-genotoxic conditioning with cd117 immunotoxin promotes robust donor chimerism and amelioration of sickle cell disease in a murine model. Transplantation and Cellular Therapy 31(2):S178. doi: 10.1016/j.jtct.2025.01.274 Objective: To investigate the efficacy of an Anti-CD117-Saporin

Clinically relevant non-genotoxic conditioning with cd117 immunotoxin promotes robust donor chimerism and amelioration of sickle cell disease in a murine model Read More »

Combining hsc base-editing with anti-cd117 antibody conditioning to correct severe combined immunodeficiency disorder in a novel mouse model

Dib C, Queenan J, Willner H, Swartzrock L, Charlesworth C, Denis M, Davis J, Nakauchi H, Liu DR (2025) Combining hsc base-editing with anti-cd117 antibody conditioning to correct severe combined immunodeficiency disorder in a novel mouse model. Transplantation and Cellular Therapy 31(2):S253-S354. doi: 10.1016/j.jtct.2025.01.385 Objective: To test whether base-edited hematopoietic stem cells (HSPCs) combined with

Combining hsc base-editing with anti-cd117 antibody conditioning to correct severe combined immunodeficiency disorder in a novel mouse model Read More »

Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions

Bohl JM, Hassan AR, Sharpe ZJ, Kola M, Shehu A, Beaudoin DL, Ichinose T (2025) Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions. 19:1547066. doi: 10.3389/fncel.2025.1547066 PMID: 39990971 Objective: To examine the roles of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the pupillary light reflex (PLR) by ablating

Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions Read More »

NGF in neuropathic pain: Understanding its role and therapeutic opportunities

García-Domínguez M (2025) NGF in neuropathic pain: Understanding its role and therapeutic opportunities. Curr Issues Mol Biol 47(2):93. doi: 10.3390/cimb47020093 PMID: 39996814 Objective: To determine the use of NGF as an important biomarker and therapeutic target in the management of neuropathic pain Summary: Taking advantage of the multifaceted dynamics of NGF could provide effective pain

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type-I nNOS neurons orchestrate cortical neural activity and vasomotion

Turner KL, Brockway DF, Hossain MdS, Griffith KR, Greenwalt DI, Zhang Q, gheres KW, Crowley NA, Drew PJ (2025) type-I nNOS neurons orchestrate cortical neural activity and vasomotion. bioRxiv 2025.01.21.634042. doi: 10.1101/2025.01.21.634042 PMID: 39896560 Objective: To uncover the role of a sparse but unusual population of genetically-distinct interneurons known as type-I nNOS neurons, using a

type-I nNOS neurons orchestrate cortical neural activity and vasomotion Read More »

Gravitostat: A homeostatic regulator of body weight

Zlatkovic J (2025) Gravitostat: A homeostatic regulator of body weight. Univ of Gothenburg Thesis. Objective: To focus on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. Summary: The main findings in this thesis include the identification of a group of neurons activated by increased load in the medial Nucleus of Solitary Tract

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Targeted delivery of cytotoxic proteins via lipid-based nanoparticles to primary Langerhans cells

Rahhal N, Rentzsch M, Seiser S, Freystätter C, Elbe-Bürger A, Rademacher C (2025) Targeted delivery of cytotoxic proteins via lipid-based nanoparticles to primary Langerhans cells. Nanoscale 17(7):4038-4046. doi: 10.1039/d4nr03638g PMID: 39775685 Summary: Saporin was used as a model protein to showcase the potential of delivering intact proteins to Langerhans cells. Authors observed specific killing of

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Guanidyl-rich α-helical polypeptide enables efficient cytosolic pro-protein delivery and CRISPR-Cas9 genome editing

Zhao Z, Zhang H, Li W, Wang Y, Wang Y, Yang H, Yin L, Liu X (2025) Guanidyl-rich α-helical polypeptide enables efficient cytosolic pro-protein delivery and CRISPR-Cas9 genome editing. J Mater Chem B 13(6):1991-2002. doi: 10.1039/d4tb02009j PMID: 39760520 Objective: To develop an efficient strategy via cationic alpha-helical polypeptide-mediated anionic proprotein delivery. Summary: The protein was

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CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

Nakano T, Okita K, Okazaki S, Yoshimoto S, Masuko S, Yagi H, Kato K, Tomioka Y, Imai K, Hamada Y, Masuko K, Shimada-Takaura K, Nagai N, Saya H, Arai T, Ishiwata T, Masuko T (2025) CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb. FEBS

CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb Read More »

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