Author name: Kristen Hartman

Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line

Kuroda M, Komatsu N, Kosai A, Hamakubo T, Abe T (2025) Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line. 37(3):450-454. doi: 10.1016/j.ajoms.2024.11.003 Objective: To confirm the antitumor effects of IT-Cetuximab (IT-Cmab= saporin-conjugated anti-EGFR antibody), which is cetuximab conjugated with a toxin, targeting salivary gland cancers—a type of cancer with […]

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Approaches for studying neuroimmune interactions in Alzheimer’s disease

Lin CCJ, Tian Y, Tanzi RE, Jorfi M (2024) Approaches for studying neuroimmune interactions in Alzheimer’s disease. Trends Immunol S1471-4906(24)00248-5. doi: 10.1016/j.it.2024.10.002 PMID: 39537528 Objective: To examine cutting-edge strategies – encompassing animal and cellular models – used to investigate the roles of peripheral immune cells in AD. Summary: Recent studies using rodent models and innovative

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Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat

Malatiali S, Oriowo M (2024) Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat. Thyroid Res 17(1):22. doi: 10.1186/s13044-024-00211-w PMID: 39491028 Objective: To elaborate the role of AngII in thyroxine-induced renal injury and the possible protective role of Ang 1–7. Summary: Losartan is more protective than captopril against thyroxine-induced

Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat Read More »

Cognitive improvement via cortical cannabinoid receptors and choline-containing lipids

Moreno-Rodríguez M, Martínez-Gardeazabal J, Bengoetxea de Tena I, Llorente-Ovejero A, Lombardero L, González de San Román E, Giménez-Llort L, Manuel I, Rodríguez-Puertas R (2024) Cognitive improvement via cortical cannabinoid receptors and choline-containing lipids. Br J Pharmacol 182(4):1038-1058. doi: 10.1111/bph.17381 PMID: 39489624 Objective: Authors hypothesized that activation of the endocannabinoid system may confer neuroprotection against cholinergic

Cognitive improvement via cortical cannabinoid receptors and choline-containing lipids Read More »

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

Chuang KH, Zhou XA, Xia Y, Li z, Qian L, Eeles E, Ngiam G, Fripp J, Coulson EJ (2024) Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux. bioRxiv 2024.08.25.609536. doi: 10.1101/2024.08.25.609536 Objective: To show that vascular-CSF coupling correlates with cortical cholinergic activity in non-demented aged humans. Summary: Waste from the brain is

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux Read More »

Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation

Blanco T, Nakagawa H, Musayeva A, Krauthammer M, Singh RB, Narimatsu A, Ge H, Shoushtari SI, Dana R (2024) Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation. JCI Insight 9(20):e182469. doi: 10.1172/jci.insight.182469 PMID: 39235864 Objective: To investigate the interaction between antigen-presenting cell subsets, specifically CD11b+ dendritic cells (DC2) and CD103+ dendritic

Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation Read More »

Progressive cancer targeting by programmable aptamer-tethered nanostructures

Mohammadi F, Zahraee H, Zibadi F, Khoshbin Z, Ramezani M, Alibolandi M, Abnous K, Taghdisi SM (2024) Progressive cancer targeting by programmable aptamer-tethered nanostructures. MedComm (2020) 5(11):e775. doi: 10.1002/mco2.775 PMID: 39434968 Objective: This review focuses on the significance of different aptamer-assembled nanoconstructs as multifunctional nucleic acid oligomeric nanoskeletons in efficient drug delivery. Summary: Saporin was

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Divergent sensory pathways of sneezing and coughing

Jiang H, Cui H, Chen M, Li F, Shen X, Guo CJ, Hoekel GE, Zhu Y, Han L, Wu K, Holtzman MJ, Liu Q (2024) Divergent sensory pathways of sneezing and coughing. Cell 187(21):5981-5997. doi: 10.1016/j.cell.2024.08.009 PMID: 39243765 Objective: To study the difference in sensory receptors and neurotransmission/modulation mechanisms between sneezing and coughing. Summary: Sneezing

Divergent sensory pathways of sneezing and coughing Read More »

Unveiling the dynamic interplay between cancer stem cells and the tumor microenvironment in melanoma: Implications for novel therapeutic strategies

Limonta P, Chiaramonte R, Casati L (2024) Unveiling the dynamic interplay between cancer stem cells and the tumor microenvironment in melanoma: Implications for novel therapeutic strategies. Cancers (Basel) 16(16):2861. doi: 10.3390/cancers16162861 PMID: 39199632 Objective: To review the bidirectional communication between melanoma cancer stem cells (CSCs) and the tumor microenvironment, highlighting its role in drug resistance

Unveiling the dynamic interplay between cancer stem cells and the tumor microenvironment in melanoma: Implications for novel therapeutic strategies Read More »

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