Author name: Kristen Hartman

Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules

Sun Y, Wu X, Li J, Radiom M, Mezzenga R, Verma CS, Yu J, Miserez A (2024) Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules. Nat Commun 15(1):10094. doi: 10.1038/s41467-024-54463-z PMID: 39572548 Objective: To systematically manipulate the sequence of Phase-separating peptides (PSPs) to unravel the relationships between their molecular structure, […]

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Fos expression in A1/C1 neurons of rats exposed to hypoxia, hypercapnia, or hypercapnic hypoxia

Kato K, Serizawa R, Yokoyama T, Nakamuta N, Yamamoto Y (2024) Fos expression in A1/C1 neurons of rats exposed to hypoxia, hypercapnia, or hypercapnic hypoxia. Neurosci Lett 843:138024. doi: 10.1016/j.neulet.2024.138024 PMID: 39442648 Objective: To compare the distribution of Fos expression in catecholaminergic neurons with immunoreactivity for dopamine-β-hydroxylase (DBH) of the ventrolateral medulla exposed to hypoxia

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Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters

Park HB, Kim KH, Kim JH, Kim SI, Oh YM, Kang M, Lee S, Hwang S, Lee H, Lee T, Park S, Lee JE, Jeong GR, Lee DH, Youn H, Choi EY, Son WC, Chung SJ, Chung J, Choi K (2024) Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters.

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Involvement of peptidergic Edinger-Westphal nucleus in the neurobiology of migraine and acute alcohol exposure

Ammar AO (2024) Involvement of peptidergic Edinger-Westphal nucleus in the neurobiology of migraine and acute alcohol exposure. Univ Pecs Thesis. Objective: To confirm the role of Edinger-Westphal nucleus/urocortin1 (EWcp/UCN1) neurons in migraine. They hypothesized that selective ablation of EWcp/UCN1 neurons will influence the migraine-related behaviors induced by CGRP. Summary: Upon selective ablation of EWcp/UCN1 neurons,

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Investigating the role of the ventral anterior cingulate cortex (vacc) in placebo analgesia

Rehal SK (2024) Investigating the role of the ventral anterior cingulate cortex (vacc) in placebo analgesia. Univ Toronto Thesis. Objective: To examine whether opioid receptors in the ventral anterior cingulate cortex (vACC) were critical for the placebo response evoked by conditioning with 10 mg/kg morphine. Summary: Significant differences were observed before and after injection of

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Spinal pain processing in arthritis: Neuron and glia (inter)actions

Schaible HG, König C, Ebersberger A (2024) Spinal pain processing in arthritis: Neuron and glia (inter)actions. J Neurochem 168(11):3644-3662. doi: 10.1111/jnc.15742 PMID: 36520021 Objective: To address the mechanisms of spinal sensitization evoked by arthritis. Summary: Neutralization of spinal cytokines by intrathecal interventions attenuates mechanical hyperalgesia. This effect may in part result from local suppression of

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Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line

Kuroda M, Komatsu N, Kosai A, Hamakubo T, Abe T (2025) Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line. 37(3):450-454. doi: 10.1016/j.ajoms.2024.11.003 Objective: To confirm the antitumor effects of IT-Cetuximab (IT-Cmab= saporin-conjugated anti-EGFR antibody), which is cetuximab conjugated with a toxin, targeting salivary gland cancers—a type of cancer with

Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line Read More »

Approaches for studying neuroimmune interactions in Alzheimer’s disease

Lin CCJ, Tian Y, Tanzi RE, Jorfi M (2024) Approaches for studying neuroimmune interactions in Alzheimer’s disease. Trends Immunol S1471-4906(24)00248-5. doi: 10.1016/j.it.2024.10.002 PMID: 39537528 Objective: To examine cutting-edge strategies – encompassing animal and cellular models – used to investigate the roles of peripheral immune cells in AD. Summary: Recent studies using rodent models and innovative

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Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat

Malatiali S, Oriowo M (2024) Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat. Thyroid Res 17(1):22. doi: 10.1186/s13044-024-00211-w PMID: 39491028 Objective: To elaborate the role of AngII in thyroxine-induced renal injury and the possible protective role of Ang 1–7. Summary: Losartan is more protective than captopril against thyroxine-induced

Losartan is more effective than angiotensin (1-7) in preventing thyroxine-induced renal injury in the rat Read More »

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