Fos expression in A1/C1 neurons of rats exposed to hypoxia, hypercapnia, or hypercapnic hypoxia

Kato K, Serizawa R, Yokoyama T, Nakamuta N, Yamamoto Y (2024) Fos expression in A1/C1 neurons of rats exposed to hypoxia, hypercapnia, or hypercapnic hypoxia. Neurosci Lett 843:138024. doi: 10.1016/j.neulet.2024.138024

Objective: To compare the distribution of Fos expression in catecholaminergic neurons with immunoreactivity for dopamine-β-hydroxylase (DBH) of the ventrolateral medulla exposed to hypoxia (10%O2), hypercapnia(8%CO2), and hypercapnic hypoxia (8%CO2and10%O2)

Summary: The number of double-immunoreactive neurons in hypercapnic hypoxia-exposed rats was comparable to that in the control group. The present results suggest that adrenergic C1 neurons are specifically activated by hypoxia and are involved in the regulation of respiratory and circulatory functions.

Usage: A previous study reported that cardiorespiratory responses to hypoxic exposure (8%O2), such as hyperventilation and tachycardia, disappeared after the injury of C1 neurons by an injection of the immunotoxin anti-DBH-saporin into the rostral ventrolateral medulla of rats.

Related Products: Anti-DBH-SAP (Cat. #IT-03)

See Also:

• Malheiros-Lima M et al. Depletion of rostral ventrolateral medullary catecholaminergic neurons impairs the hypoxic ventilatory response in conscious rats. Neuroscience 351:1-14, 2017.