Author name: Kristen Hartman

Cholinergic neurotransmission during performance of a sustained attention task after traumatic brain injury

Moschonas EH (2024) Cholinergic neurotransmission during performance of a sustained attention task after traumatic brain injury. Univ Pittsburgh School of Medicine Thesis. Objective: To elucidate the role of basal forebrain cholinergic neurons (BFCNs) in mediating attentional performance and ACh efflux Summary: Saporin-induced lesions to the nbM impaired signal detection accuracy during performance of the Sustained […]

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Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss

Keilhoz A, Pathak I, Smith CL, Osman KL, Smith L, Oti G, Golzy M, Mz L, Lever TE, Nichols NL (2024) Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss. Front Neurol 15:1441529. doi: 10.3389/fneur.2024.1441529 PMID: 39296960 Objective: To investigate the effects of a strength endurance

Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss Read More »

Enhancing monoclonal antibodies with natural products: Mechanisms and applications

Gunasekaran M, Sarvananda L, Premarathna AD, (2025) Enhancing monoclonal antibodies with natural products: Mechanisms and applications. Intelligent Pharmacy 3(1):84-89. doi: 10.1016/j.ipha.2024.09.002 Objective: To investigate the novel application of beta-glucan analogs engineered for enhanced immunomodulatory effects, targeting not only malignant cells but also the tumor microenvironment to optimize mAb penetration. Summary: By combining plant-based expression systems

Enhancing monoclonal antibodies with natural products: Mechanisms and applications Read More »

Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation

Kostenko A, Prezzavento O, de Leo G, D’Arco D, Gulion R, Caccamo A, Leanza G (2024) Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation. J Alzheimers Dis 101(3):797-811. doi: 10.3233/JAD-240618 PMID: 39240642 Objective: This study sought to assess the role of (±)-cyclopropane carboxylate (PPCC) on

Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation Read More »

Distinct cholinergic circuits underlie discrete effects of reward on attention. Front Mol Neurosci

Runyon K, Bui T, Mazanek S, Hartle A, Marschalko K, Howe WM (2024) Distinct cholinergic circuits underlie discrete effects of reward on attention. Front Mol Neurosci. Front Mol Neurosci 17:1429316. doi: 10.3389/fnmol.2024.1429316 PMID: 39268248 Objective: Review the basic neuroanatomy of attention, reward, and cholinergic systems. Summary: Authors examined specific contexts in which attention and reward

Distinct cholinergic circuits underlie discrete effects of reward on attention. Front Mol Neurosci Read More »

Plant-derived extracellular vesicles: a synergetic combination of a drug delivery system and a source of natural bioactive compounds

Langellotto MD, Rassu G, Serri C, Demartis S, Giunchedi P, Gavini E (2024) Plant-derived extracellular vesicles: a synergetic combination of a drug delivery system and a source of natural bioactive compounds. Springer Nature 11(3):831-845. doi: 10.1007/s13346-024-01698-4 PMID: 39196501 Objective: This review intends to provide adequate tools for studying and developing drug delivery systems based on

Plant-derived extracellular vesicles: a synergetic combination of a drug delivery system and a source of natural bioactive compounds Read More »

Role of the locus coeruleus arousal promoting neurons in maintaining brain criticality across the sleep-wake cycle

Huo C, Lombardi F, Blanco-Centurion C, Shiromani PJ, Ivanov PC (2024) Role of the locus coeruleus arousal promoting neurons in maintaining brain criticality across the sleep-wake cycle. J Neurosci 44(35):e1939232024. doi: 10.1523/JNEUROSCI.1939-23.2024 PMID: 38951035 Objective: To investigate dynamics of θ- and δ-bursts during the sleep-wake cycle of rats with lesion in the wake-promoting locus coeruleus

Role of the locus coeruleus arousal promoting neurons in maintaining brain criticality across the sleep-wake cycle Read More »

From past to future: 50 years of pharmacological interventions to treat narcolepsy

Konofal E (2024) From past to future: 50 years of pharmacological interventions to treat narcolepsy. Pharmacol Biochem Behav 241:173804. doi: 10.1016/j.pbb.2024.173804 PMID: 38852786 Objective: This review article discusses the historical progression and transformative insights that have characterized the treatment of narcolepsy from its initial documentation to the present day. Summary: The research continues to push

From past to future: 50 years of pharmacological interventions to treat narcolepsy Read More »

A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch

Guo SS, Gong Y, Zhang TT, Su XY, Wu YJ, Yan YX, Cao Y, Song XL, Xie JC, Wu D, Jiang Q, Li Y, Zhao X, Zhu MX, Xu TL, Liu MG (2024) A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch. Sci Adv 10(33):eadn6272. doi: 10.1126/sciadv.adn6272 PMID: 39150998 Objective:

A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch Read More »

A cocktail of engineered chimeric antibodies targeting the central nervous system produces a broad-spectrum therapeutic effect for symptomatic rabies

Zhao L, Ren Z, Wang C, Wang H, Wu Q, Hou Q, Qi X, He W, Zhang X, Wan J , Zhoui M, Fu Z (2024) A cocktail of engineered chimeric antibodies targeting the central nervous system produces a broad-spectrum therapeutic effect for symptomatic rabies. Research Square preprint. doi: 10.21203/rs.3.rs-4838561/v1 Objective: To construct and assess

A cocktail of engineered chimeric antibodies targeting the central nervous system produces a broad-spectrum therapeutic effect for symptomatic rabies Read More »

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