Author name: Kristen Hartman

Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases

O’Sullivan JA, Youngblood BA, Schleimer RP, Bochner BS (2024) Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases. Semin Immunol 69:101799. doi: 10.1016/j.smim.2023.101799 PMID: 37413923 Objective: To review a subset of Siglecs and their various endogenous or synthetic sialoside ligands that regulate eosinophil and mast cell function and survival. Summary: Sialic […]

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Enhancing pancreatic cancer chemotherapy through photochemical internalisation

Rosado M, Mahamed I, Garcia-Sampedro A, MacRoberts S, Selbo P, Pereira S, Acedo P (2024) Enhancing pancreatic cancer chemotherapy through photochemical internalisation. Cancer Res 84 (17_Supplement_2):A027. doi: 10.1158/1538-7445.PANCREATIC24-A027 Objective: The aim is to use the technique called Photochemical Internalisation (PCI), a light-triggered intracellular drug delivery method which combines low dose PhotodynamicTherapy (PDT) with chemotherapy, to

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Circadian influences on feeding behavior

la Fleur SE, Blancas-Velazquez AS, Stenvers DJ, Kalsbeek A (2024) Circadian influences on feeding behavior. Nauropharmacology 256:110007. doi: 10.1016/j.neuropharm.2024.110007 PMID: 38795953 Objective: To review the effect of deletion of different clock genes on feeding behavior. Summary: The most prominent effect on feeding behavior has been observed in Clock mutants, where as deletion of Bmal1 and

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T cell death-associated gene 8-mediated distinct signaling pathways modulate the early and late phases of neuropathic pain

Dai SP, Yang CC, Chin Y, Sun WH (2024) T cell death-associated gene 8-mediated distinct signaling pathways modulate the early and late phases of neuropathic pain. iScience 27(10):110955. doi: 10.1016/j.isci.2024.110955 PMID: 39381739 Objective: To elucidate how T cell death-associated gene 8 (TDAG8)-mediated signaling modulates neuron activities in a mouse model of chronic constriction injury-induced neuropathic

T cell death-associated gene 8-mediated distinct signaling pathways modulate the early and late phases of neuropathic pain Read More »

Rational engineering of cytosolic delivery systems for protein therapeutics

Lv J, Liu X, Yin L, Cheng Y (2024) Rational engineering of cytosolic delivery systems for protein therapeutics. Acc Mater Res 5(10):1194-1209. doi: 10.1021/accountsmr.4c00149 Objective: To summarize recent advances in the rational design of cytosolic protein delivery systems. Summary: Saporin, a cell membrane-impermeable toxin, kills cancer cells by inhibiting protein synthesis. To fully utilize the

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Correction of osteopetrosis in the neonate oc/oc murine model after lentiviral vector gene therapy and non-genotoxic conditioning

Penna S, Zecchillo A, Di Verniere M, Fontana E, Iannello V, Palagano E, Mantero S, Cappelleri A, Rizzoli E, Santi L, Crisafulli L, Filibian M, Forlino A, Basso-Ricci L, Scala S, Scanziani E, Schinke T, Ficara F, Sobacchi C, Villa A, Capo V (2024) Correction of osteopetrosis in the neonate oc/oc murine model after lentiviral

Correction of osteopetrosis in the neonate oc/oc murine model after lentiviral vector gene therapy and non-genotoxic conditioning Read More »

Cholinergic neurotransmission during performance of a sustained attention task after traumatic brain injury

Moschonas EH (2024) Cholinergic neurotransmission during performance of a sustained attention task after traumatic brain injury. Univ Pittsburgh School of Medicine Thesis. Objective: To elucidate the role of basal forebrain cholinergic neurons (BFCNs) in mediating attentional performance and ACh efflux Summary: Saporin-induced lesions to the nbM impaired signal detection accuracy during performance of the Sustained

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Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss

Keilhoz A, Pathak I, Smith CL, Osman KL, Smith L, Oti G, Golzy M, Mz L, Lever TE, Nichols NL (2024) Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss. Front Neurol 15:1441529. doi: 10.3389/fneur.2024.1441529 PMID: 39296960 Objective: To investigate the effects of a strength endurance

Tongue exercise ameliorates structural and functional upper airway deficits in a rodent model of hypoglossal motor neuron loss Read More »

Enhancing monoclonal antibodies with natural products: Mechanisms and applications

Gunasekaran M, Sarvananda L, Premarathna AD, (2025) Enhancing monoclonal antibodies with natural products: Mechanisms and applications. Intelligent Pharmacy 3(1):84-89. doi: 10.1016/j.ipha.2024.09.002 Objective: To investigate the novel application of beta-glucan analogs engineered for enhanced immunomodulatory effects, targeting not only malignant cells but also the tumor microenvironment to optimize mAb penetration. Summary: By combining plant-based expression systems

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Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation

Kostenko A, Prezzavento O, de Leo G, D’Arco D, Gulion R, Caccamo A, Leanza G (2024) Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation. J Alzheimers Dis 101(3):797-811. doi: 10.3233/JAD-240618 PMID: 39240642 Objective: This study sought to assess the role of (±)-cyclopropane carboxylate (PPCC) on

Cognitive and histopathological alterations in rat models of early- and late-phase memory dysfunction: Effects of sigma-1 receptor activation Read More »

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