la Fleur SE, Blancas-Velazquez AS, Stenvers DJ, Kalsbeek A (2024) Circadian influences on feeding behavior. Nauropharmacology 256:110007. doi: 10.1016/j.neuropharm.2024.110007 PMID: 38795953
Objective: To review the effect of deletion of different clock genes on feeding behavior.
Summary: The most prominent effect on feeding behavior has been observed in Clock mutants, where as deletion of Bmal1 and Per1/2 only disrupts the day-night rhythm, but not overall intake. Damaging leptin-sensitive cells within the ARC using saporin-leptin injections (reducing the number of POMC and AgRP cells) induced a-rhythmicity in feeding behavior when animals were held either in a light-dark rhythm or continuous darkness, providing evidence that leptin-sensitive cells of the ARC are important for circadian feeding rhythmicity.
Related Products: Leptin-SAP (Cat. #IT-47)
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