Leptin-SAP [IT-47, KIT-47]

a tool for eliminating cells that express leptin receptor; targeted via recombinant mouse leptin, eliminated via saporin

SKU: IT-47 Category: Host: mouse | Reactivity: Mouse, rat | Conjugate: saporin | Usage: eliminates cells |
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Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP is an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.

Leptin-SAP is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. It specifically eliminates cells that recognize and internalize leptin.

Leptin-SAP is available individually (Cat. #IT-47) or as a kit (Cat. #KIT-47) which includes Leptin-SAP and Saporin (Cat. #PR-01).

Targeting Collection (Cat. #TC-01) is sample pack of targeted toxins is useful in studying various aspects of satiety, appetite, and metabolism. It contains samples of NPY-SAP (Cat. #IT-28)Oxytocin-SAP (Cat. #IT- 46)Leptin-SAP (Cat. #IT-47), and Saporin (Cat. #PR-01).