Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP is an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.
Leptin-SAP is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. It specifically eliminates cells that recognize and internalize leptin.
Targeting Collection (Cat. #TC-01) is sample pack of targeted toxins is useful in studying various aspects of satiety, appetite, and metabolism. It contains samples of NPY-SAP (Cat. #IT-28), Oxytocin-SAP (Cat. #IT- 46), Leptin-SAP (Cat. #IT-47), and Saporin (Cat. #PR-01).