Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP eliminates leptin receptor-expressing cells and could be used as an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.
This toxin could be used to eliminate leptin receptor-expressing cells and as an excellent complement to NPY-SAP (Cat. #IT-28) and Oxytocin-SAP (Cat. #IT-46) in studying satiety, appetite, and metabolism.
Leptin-SAP specifically eliminates cells that recognize and internalize leptin in rat and mouse. It is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. There is a <65% sequence identity between primate, dog, bovine, porcine, rat, and mouse.
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