Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP is an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.
Leptin-SAP is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. It specifically eliminates cells that recognize and internalize leptin.
keywords: Leptin, NPY, AgRP, α-melanocyte-stimulating hormone, alpha-MSH, saporin, eating, appetite, brain, neuroscience