Leptin-SAP [IT-47, KIT-47]

a tool for eliminating cells that express leptin receptor; targeted via recombinant mouse leptin, eliminated via saporin

SKU: IT-47 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Host: mouse | Reactivity: mouse, rat | Conjugate: saporin | Usage: eliminates cells |

Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP is an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.

Leptin-SAP is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. It specifically eliminates cells that recognize and internalize leptin.

Leptin-SAP is available individually (Cat. #IT-47) or as a kit (Cat. #KIT-47) which includes Leptin-SAP and Blank-SAP (Cat. #IT-21).

keywords: Leptin, NPY, AgRP, α-melanocyte-stimulating hormone, alpha-MSH, saporin, eating, appetite, brain, neuroscience


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