Leptin-SAP [IT-47]

a tool for eliminating cells that express leptin receptor; targeted via recombinant mouse leptin, eliminated via saporin

SKU: IT-47 Category: Product Size: 25 ug, 100 ug, 250 ug, 1 mg | Host: mouse | Reactivity: Mouse, rat | Conjugate: saporin | Usage: eliminates cells |
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Description

Leptin is a 16 kDa protein hormone that activates leptin receptors, and plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin inhibits the activity of neurons that contain neuropeptide Y (NPY) and agouti-related peptide (AgRP), and increases the activity of neurons expressing α-melanocyte-stimulating hormone (alpha-MSH), and thereby is a very influential mediator of satiety. Leptin-SAP eliminates leptin receptor-expressing cells and could be used as an excellent complement to NPY-SAP and Oxytocin-SAP in studying satiety, appetite, and metabolism.

This toxin could be used to eliminate leptin receptor-expressing cells and as an excellent complement to NPY-SAP (Cat. #IT-28) and Oxytocin-SAP (Cat. #IT-46) in studying satiety, appetite, and metabolism.

Leptin-SAP specifically eliminates cells that recognize and internalize leptin in rat and mouse. It is a chemical conjugate of the recombinant mouse leptin and the ribosome-inactivating protein, saporin. There is a <65% sequence identity between primate, dog, bovine, porcine, rat, and mouse.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

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