Author name: Kristen Hartman

Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo

Kolster M, Sonntag A, Weise C, Correa J, Fuchs H, Walther W, Fernandez-Megia E, Weng A (2024) Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo. ACS Appl Mater Interfaces 16(28):36095-36105. doi: 10.1021/acsami.4c05846 PMID: 38970470 Objective: Using Saponin to enhance delivery of gene therapies to cancer cells Summary: […]

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Peptide-hitchhiking for the development of nanosystems in glioblastoma

Branco F, Cunha J, Mendes M, Vitorino C, Sousa JJ (2024) Peptide-hitchhiking for the development of nanosystems in glioblastoma. ACS Nano 18(26):16359-16394. doi: 10.1021/acsnano.4c01790 PMID: 38861272 Objective: To review single and multiligand strategies to deliver therapeutic treatment to Glioblastoma (GBM). Summary: The exploration of multitargeting ligands has shown great promise in GBM treatment, particularly when

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Mitigating the functional deficit after neurotoxic motoneuronal loss by an inhibitor of mitochondrial fission

Ciuro M, Sangiorgio M, Cacciato V, Cantone G, Fichera C, Salvatorelli L, Magro G, Leanza G, Vecchio M, Valle MS, Gulino R (2024) Mitigating the functional deficit after neurotoxic motoneuronal loss by an inhibitor of mitochondrial fission. Int J Mol Sci 25(13):7059. doi: 10.3390/ijms25137059 PMID: 39000168 Objective: To use the Cholera Toxin B-Saporin (CTB-SAP) mouse

Mitigating the functional deficit after neurotoxic motoneuronal loss by an inhibitor of mitochondrial fission Read More »

State-of-the-art and new treatment approaches for spinal cord tumors

Kumawat C, Takahashi T, Date I, Tomita Y, Tanaka M, Arataki S, Komatsubara T, Flores AOP, Yu D, Jain M (2024) State-of-the-art and new treatment approaches for spinal cord tumors. Cancers (Basel) 16(13):2360. doi: 10.3390/cancers16132360 PMID: 39001422 Objective: To discuss innovative approaches in treating spinal cord tumors. Summary: Gene therapy holds the potential to modify

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Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease

Kang Y, Toyoda H, Saito M (2024) Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease. Front Cell Neurosci 18:1425645. doi: 10.3389/fncel.2024.1425645 PMID: 38994328 Summary: It remains unclear how masticatory dysfunction can induce brain degeneration similar to Alzheimer’s Disease

Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer’s disease Read More »

Engineering an antibody-discernible and functional CD45 variant on hematopoietic stem and progenitor cells via base editing

Garaudé S (2024) Engineering an antibody-discernible and functional CD45 variant on hematopoietic stem and progenitor cells via base editing. Univ Basel Thesis. Objective: To develop a system for a cell surface marker present on all hematopoietic cell to deplete malignant cells. Authors screened CD45’s extracellular domain regions with base editors and generated multiple CD45 protein

Engineering an antibody-discernible and functional CD45 variant on hematopoietic stem and progenitor cells via base editing Read More »

Approach/avoidance behavior to novel objects is correlated with the serotonergic and dopaminergic systems in the brown rat (rattus norvegicus)

Kiyokawa Y, Ootaki M, Kambe Y, Tanaka KD, Kimura G, Tanikawa T, Takeuchi Y (2024) Approach/avoidance behavior to novel objects is correlated with the serotonergic and dopaminergic systems in the brown rat (rattus norvegicus). Neuroscience 549:110-120. doi: 10.1016/j.neuroscience.2024.05.003 PMID: 38723837 Objective: To compare the dopaminergic, serotonergic, and noradrenergic systems immunohistochemically among rats. Summary: The serotonergic

Approach/avoidance behavior to novel objects is correlated with the serotonergic and dopaminergic systems in the brown rat (rattus norvegicus) Read More »

Endosomal escape in magnetic nanostructures: Recent advances and future perspectives

Shirsat SD, Londhe PV, Gaikwad AP, Rizwan M, Laha SS, Khot VM, Achal C, Tabish TA, Thorat ND (2024) Endosomal escape in magnetic nanostructures: Recent advances and future perspectives. Materials Today Advances 22:100484. doi: 10.1016/j.mtadv.2024.100484 Objective: To investigate the use of magnetic nanoparticles (MNPs) as functional nano-objects to enhance the therapeutic effects by disrupting or

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A body–brain circuit that regulates body inflammatory responses

Jin H, Li M, Jeong E, Castro-Martinez F, Zuker CS (2024) A body–brain circuit that regulates body inflammatory responses. Nature 630(8017):695-703. doi: 10.1038/s41586-024-07469-y PMID: 38692285 Objective: To show that a peripheral immune insult strongly activates the body–brain axis to regulate immune responses. Summary: Using Anti-DBH-SAP, the authors demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with

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Phytochemistry and biological activities of agrostemma genus-a review

Smakosz A, Matkowski A, Nawrot-Hadzik I (2024) Phytochemistry and biological activities of agrostemma genus-a review. Plants (Basel) 13(12):1673. doi: 10.3390/plants13121673 PMID: 38931105 Objective: In this review, papers focused on the chemical composition and bioactivity of the two accepted species of the Agrostemma genus were examined. Summary: A vast amount of data exists about the cytotoxicity

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