Author name: Kristen Hartman

Navigating the neurological frontier: Macromolecular marvels in overcoming blood-brain barrier challenges for advanced drug delivery

Zeynalzadeh E, Khodadadi E, Khodadadi E, Ahmadian Z, Kazeminava F, Rasoulzadehzali M, Samadi Kafil H (2024) Navigating the neurological frontier: Macromolecular marvels in overcoming blood-brain barrier challenges for advanced drug delivery. Heliyon 10(15):e35562. doi: 10.1016/j.heliyon.2024.e35562 PMID: 39170552 Objective: To understand how nanoparticles interact with the blood-brain barrier. Summary: Enhancing the bioavailability of nano formulations at […]

Navigating the neurological frontier: Macromolecular marvels in overcoming blood-brain barrier challenges for advanced drug delivery Read More »

Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function

Zhang Q, Xue J, Tang J, Wu S, Liu Z, Wu C, Liu C, Liu Y, Lin J, Han J, Liu L, Chen Y, Yang J, Li Z, Zhao L, Wei Y, Li Y, Zhuo Y (2024) Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function. Sci Adv 10(31):eado0866. doi: 10.1126/sciadv.ado0866

Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function Read More »

Longitudinal intravascular antibody labeling identified regulatory t cell recruitment as a therapeutic target in a mouse model of lung cancer

Shanahan SL, Kunder N, Inaku C, Hagan NB, Gibbons G, Mathey-Andrews N, Anandappa G, Soares S, Pauken KE, Jacks T, Schenkel JM (2024) Longitudinal intravascular antibody labeling identified regulatory t cell recruitment as a therapeutic target in a mouse model of lung cancer. J Immunol ji2400268. doi: 10.4049/jimmunol.2400268 PMID: 39082930 Objective: To develop an intravascular

Longitudinal intravascular antibody labeling identified regulatory t cell recruitment as a therapeutic target in a mouse model of lung cancer Read More »

Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma

Islam S, Gleber-Netto FO, Mulcahy CF, Glaun MDE, Srivastava S, Hunt PJ, Williams MD, Barbon CE, Spiotto M, Zhao W, Adebayo A, Akhter S, Xie T, Debnath KC, Sathishkumar HN, Myers B, Lothumalla S, Yama I, Burks JK, Gomez J, Rao X, Wang J, Woodman K, Mansour J, Arenkiel B, Osman KL, Haxton C, Lever

Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma Read More »

Unraveling mechanisms of protein encapsulation and release in coacervates via molecular dynamics and machine learning

Wang Y, Zou R, Zhou Y, Zheng Y, Peng C, Liu Y, Tan H, Fu Q, Ding M (2024) Unraveling mechanisms of protein encapsulation and release in coacervates via molecular dynamics and machine learning. Chem Sci 15(33):13442-13451. doi: 10.1039/D4SC03061C PMID: 39183928 Objective: To investigate bovine serum albumin (BSA) protein encapsulation and release within polylysine/polyglutamate (PLys/PGlu)

Unraveling mechanisms of protein encapsulation and release in coacervates via molecular dynamics and machine learning Read More »

Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry

Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T (2024) Pannexin-1 channel

Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry Read More »

Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity

Su Y, Xu J, Zhu Z, Chin J, Xu L, Yu H, Nudell V, Dash B, Moya EA, Ye L, Nimmerjahn A, Sun X (2024) Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity. Nature 631(8021):601-609. doi: 10.1038/s41586-024-07608-5 PMID: 38987587 Objective: To map a full allergen circuit from the lung to the brainstem and back to the

Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity Read More »

A non-invasive stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Bryder D, Konturk-Ciesla A, Zhang Q, Kharazi S (2024) A non-invasive stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice. Research Square doi: 10.21203/rs.3.rs-4528815/v1 Objective: To develop a murine transplantation model based on low-intensity conditioning protocols using antibody-mediated Hematopoietic stem cell. Summary: Authors demonstrate that young HSCs, once transplanted, survive and thrive

A non-invasive stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice Read More »

A glycoprotein-based surface-enhanced raman spectroscopy–lateral flow assay method for abrin and ricin detection

Xia L, Luo L, Liu J, Liu L, Han H, Xia R, Guo L, Xie J, Tang L (2024) A glycoprotein-based surface-enhanced raman spectroscopy–lateral flow assay method for abrin and ricin detection. Toxins (Basel) 16(7):312. doi: 10.3390/toxins16070312 PMID: 39057952 Objective: To generate stable and high-affinity nanotags, via an efficient freezing method, to serve as the

A glycoprotein-based surface-enhanced raman spectroscopy–lateral flow assay method for abrin and ricin detection Read More »

Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo

Kolster M, Sonntag A, Weise C, Correa J, Fuchs H, Walther W, Fernandez-Megia E, Weng A (2024) Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo. ACS Appl Mater Interfaces 16(28):36095-36105. doi: 10.1021/acsami.4c05846 PMID: 38970470 Objective: Using Saponin to enhance delivery of gene therapies to cancer cells Summary:

Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo Read More »

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