Author name: Kristen Hartman

Phytochemistry and biological activities of agrostemma genus-a review

Smakosz A, Matkowski A, Nawrot-Hadzik I (2024) Phytochemistry and biological activities of agrostemma genus-a review. Plants (Basel) 13(12):1673. doi: 10.3390/plants13121673 PMID: 38931105 Objective: In this review, papers focused on the chemical composition and bioactivity of the two accepted species of the Agrostemma genus were examined. Summary: A vast amount of data exists about the cytotoxicity […]

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A body–brain circuit that regulates body inflammatory responses

Jin H, Li M, Jeong E, Castro-Martinez F, Zuker CS (2024) A body–brain circuit that regulates body inflammatory responses. Nature 630(8017):695-703. doi: 10.1038/s41586-024-07469-y PMID: 38692285 Objective: To show that a peripheral immune insult strongly activates the body–brain axis to regulate immune responses. Summary: Using Anti-DBH-SAP, the authors demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with

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The role of the ventral nucleus of the trapezoid body in the auditory prepulse inhibition of the acoustic startle reflex

Barioni NO, Beduschi RS, da Silva AV, Martins MG, Almeida-Francia CCD, Rodrigues SA, López DE, Gómez-Nieto R, Horta-Júnior JAC (2024) The role of the ventral nucleus of the trapezoid body in the auditory prepulse inhibition of the acoustic startle reflex. Hearing Research 450:109070. doi: 10.1016/j.heares.2024.109070 PMID: 38972084 Objective: To study the acoustic startle response through

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Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus

Simpson J, Starke CE, Ortiz AM, Ransier A, Darko S, Llewellyn-Lacey S, Fennessey CM, Keele BF, Douek DC, Price DA, Brenchley JM (2024) Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus. JCI Insight e174168. doi: 10.1172/jci.insight.174168 PMID: 38885329 Objective: To investigate the role of gag epitope-specific CD8+ T cells

Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus Read More »

Cholinergic interneurons in the dorsal striatum play an important role in the acquisition of duration memory

Nishioka M, Hata T (2024) Cholinergic interneurons in the dorsal striatum play an important role in the acquisition of duration memory. Eur J Neurosci 59(11):3061-3073. doi: 10.1111/ejn.16337 PMID: 38576223 Objective: To investigate duration-memory formation in the dorsal striatum. Summary: Rats were sufficiently trained using a peak-interval 20s procedure and then infused with anti-choline acetyltransferase–saporin into

Cholinergic interneurons in the dorsal striatum play an important role in the acquisition of duration memory Read More »

Rodent models of alzheimer’s disease: Past misconceptions and future prospects

Collins HM, Greenfield S (2024) Rodent models of alzheimer’s disease: Past misconceptions and future prospects. Int J Mol Sci 25(11):6222. doi: 10.3390/ijms25116222 PMID: 38892408 Objective: To outline the various apparent causes of Alzheimer’s Disease (AD) and evaluate the success or otherwise of their reproduction in rodents. Summary: To understand the pathogenesis of AD and how

Rodent models of alzheimer’s disease: Past misconceptions and future prospects Read More »

Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets

Nodal FR, Leach ND, Keating P, Dahmen JC, Zhao D, King AJ, Bajo VM (2024) Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets. Hear Res 447:109025. doi: 10.1016/j.heares.2024.109025 PMID: 38733712 Objective: To explore whether behavioral deficits are associated with changes in the response properties of cortical neurons,

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Hits and misses with animal models of narcolepsy and the implications for drug discovery

Nirogi R, Jayarajan P, Benade V, Abraham R, Goyal VK (2024) Hits and misses with animal models of narcolepsy and the implications for drug discovery. Expert Opin Drug Discov 19(6):755-768. doi: 10.1080/17460441.2024.2354293 PMID: 38747534 Objective: To review the usage of Orexin-B-SAP treated rats in the development of drug candidates for the treatment of narcolepsy. Summary:

Hits and misses with animal models of narcolepsy and the implications for drug discovery Read More »

Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing

Yang Q, Liu L, He F, Zhao W, Chen Z, Wu X, Rao B, Lin X, Mao F, Qu J, Zhang J (2024) Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing. Int J Med Sci 21(8):1472-1490. doi: 10.7150/ijms.95598 PMID: 38903914 Objective: To analyze the single-cell transcriptome in healthy and injured retinas

Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing Read More »

Cholinergic modulation of dopamine-related effects of ethanol in the rat

Loften A (2024) Cholinergic modulation of dopamine-related effects of ethanol in the rat. Univ Gothenburg Thesis. Objective: To explore the role of acetylcholine and cholinergic interneurons (CIN) in ethanol-induced dopamine (DA) release and in the reinforcing effects of ethanol. Summary: The author’s thesis supports an important role of accumbal CIN in ethanol ́s DA releasing

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