Kolster M, Sonntag A, Weise C, Correa J, Fuchs H, Walther W, Fernandez-Megia E, Weng A (2024) Broadening the scope of sapofection: Cationic peptide-saponin conjugates improve gene delivery in vitro and in vivo. ACS Appl Mater Interfaces doi: 10.1021/acsami.4c05846 PMID: 38970470
Objective: Using Saponin to enhance delivery of gene therapies to cancer cells
Summary: Saponins hold promise in enhancing the endosomal escape of gene therapy vectors into cells, thereby increasing efficacy. The Saponin, SO1861, was conjugated to either a pH-sensitive peptide linker or Saporin, and internalization of the payload was measured. Saponin was shown to enhance delivery of gene therapies to cells of an aggressively growing neuroblastoma allograft model in mice.
Related Products: Saporin (Cat. #PR-01)