Author name: Kristen Hartman

Extracellular vesicles: A new frontier in the theranostics of cardiovascular diseases

Fu E, Li Z (2024) Extracellular vesicles: A new frontier in the theranostics of cardiovascular diseases. iRadiology 2(3):240-259. doi: 10.1002/ird3.77 Objective: To delve into the evolving landscape of extracellular vesicles (EVs), uncovering their diagnostic and therapeutic prospects and emphasizing their growing importance in shaping the future of cardiovascular theranostics Summary: The ability of EVs to […]

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Where does the saporin payload release after internalization?

Question: Where does the saporin payload release after internalization? For example, does it require trafficking into a late endosome/lysosomal compartment?  Answer: Thank you for reaching out to us. Hopefully I can help answer some of your questions regarding what happens to saporin after being internalized.  I would first like to refer you to an article we

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Spinal TNF-α receptor expression in a rodent model of respiratory motor neuron death

Lewis R, Smith C, Nichols N (2024) Spinal TNF-α receptor expression in a rodent model of respiratory motor neuron death. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.1401 Objective: To create a model from respiratory deficit and study the role of inflammation in phrenic long-term facilitation. Summary: Some neurodegenerative diseases are characterized by deficits in respiratory neurons,

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Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons

Toledo C, Del Rio R (2024) Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.2540 Objective: To characterize cardiorespiratory function in AD patients and then to determine the role of RVLM-C1 neurons in autonomic and sleep-disordered breathing in APP/PS1 double transgenic mice, and experimental

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The progestinic drug, etonogestrel, rescues breathing in a rodent model of central chemoreflex impairment

Janes T, Cardani S, Pagliardini S (2024) The progestinic drug, etonogestrel, rescues breathing in a rodent model of central chemoreflex impairment. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.978 Objective: Assessing the efficacy of etonogestrel as a treatment to congenital hypoventilation syndrome (CCHS). Summary: Etonogestrel can stimulate breathing and CO2-chemoreflexes and could be used to treat congenital

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Tongue exercise-induced plasticity in upper airway EMG activity in a model of hypoglossal motor neuron loss

Keilholz A, Osman K, Smith C, Streeter K, Ozden I, Lever T, Nichols N (2024) Tongue exercise-induced plasticity in upper airway EMG activity in a model of hypoglossal motor neuron loss. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.1405 Objective: To study the impact of XII LMN degeneration and develop therapies to improve swallowing and breathing function/coordination.

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Longitudinal assessment of outcome measures of diaphragm motor unit connectivity as biomarkers of phrenic motor unit degeneration and compensation

Ketabforoush A, Wang M, Smith C, Arnold WD, Nichols N (2024) Longitudinal assessment of outcome measures of diaphragm motor unit connectivity as biomarkers of phrenic motor unit degeneration and compensation. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.1402 Objective: Using CTB-SAP to lesion motor neurons and measuring motor neuron connectivity and cell death, as a model for

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Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Kniffin A, Bangasser DA, Parikh V (2024) Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications. Eur J Neurosci 59(9):2155-2180. doi: 10.1111/ejn.15999 PMID: 37118907 Objective: Review current research highlighting the contributions of cholinergic septohippocampal pathway (SHP) in modulating memory encoding, consolidation, and retrieval. Summary: Authors presented evidence generated from

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications Read More »

Pollen-specific expression of ecori restriction endonuclease for bioconfinement in panicum virgatum l

Stockdale JN (2024) Pollen-specific expression of ecori restriction endonuclease for bioconfinement in panicum virgatum l. Univ Tennessee Thesis. Objective: In this study, pollen-specific promoters controlling the expression of the EcoRI endonuclease, interrupted by a catalase intron, were evaluated for efficacy to produce sterile pollen. Summary: The TaPSG719, PvPS1, Osg6B, OsRTS, and Zm13 promoters were assessed

Pollen-specific expression of ecori restriction endonuclease for bioconfinement in panicum virgatum l Read More »

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