Jin H, Li M, Jeong E, Castro-Martinez F, Zuker CS (2024) A body–brain circuit that regulates body inflammatory responses. Nature 630(8017):695-703. doi: 10.1038/s41586-024-07469-y PMID: 38692285
Objective: To show that a peripheral immune insult strongly activates the body–brain axis to regulate immune responses.
Summary: Using Anti-DBH-SAP, the authors demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with distinct populations of vagal neurons to inform the brain of an emerging inflammatory response. In turn, the brain tightly modulates the course of the peripheral immune response. Genetic silencing of this body–brain circuit produced unregulated and out-of-control inflammatory responses. By contrast activating this circuit affords neural control of immune responses.
Usage: Bilateral injection into the caudal nucleus of the solitary tract of mice with Anti-DBH–SAP (IT-03, 20 ng per side).
Related Products: Anti-DBH-SAP (Cat. #IT-03)