Author name: Kristen Hartman

Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex

Bohl JM, Hassan AR, Sharpe ZJ, Kola M, Ayub M, Pandey Y, Shehu A, Ichinose T (2024) Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex. bioRxiv 2024.05.14.594181. doi: 10.1101/2024.05.14.594181 Objective: To examine the role of rod and cone photoreceptors in pupillary light reflex (PLR) by acutely ablating photoreceptors. Summary: Results demonstrate […]

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Flp-recombinase mouse line for genetic manipulation of ipRGCs

Contreras E, Liang C, Mahoney HL, Javier JL, Luce ML, Labastida Medina K, Bozza T, Schmidt TM (2024) Flp-recombinase mouse line for genetic manipulation of ipRGCs. bioRxiv 2024.05.06.592761. doi: 10.1101/2024.05.06.592761 PMID: 38766000 Objective: To report the generation and characterization of a new mouse line (Opn4FlpO), in which FlpO is expressed from the Opn4 locus, to

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Extra-hippocampal contributions to social memory: The role of septal nuclei

Shivakumar AB, Mehak SF, Jijimon F, Gangadharan G (2024) Extra-hippocampal contributions to social memory: The role of septal nuclei. Biol Psychiatry 6:835-847. doi: 10.1016/j.biopsych.2024.04.018 PMID: 38718881 Objective: Review neural circuit mechanisms that underlie social memory, with a special emphasis on the septum. Summary: Understanding the complexities of the septohippocampal axis will allow targeted therapies to

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Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats

Meng XT, Song SY, Li Y, Peng S, Zhang LC (2024) Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats. Research Square doi: 10.21203/rs.3.rs-4258857/v1 Objective: To study the effects of Dexmedetomidine (DEX) on pain modulation. Summary: Dexmedetomidine is an alpha 2-adrenergic receptor agonist with sedative, analgesic, and

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iPSC derived choroidal endothelial cell delivery using laminin-based hydrogels for the treatment of AMD

Pandala N, Han I, Meyering E, Stone EM, Mullins RF, Tucker BA (2024) iPSC derived choroidal endothelial cell delivery using laminin-based hydrogels for the treatment of AMD. ARVO Annual Meeting 65(7):1542. Objective: To demonstrate an interventional therapy for age-related macular degeneration (AMD) using a rat model. Summary: In this study, induced pluripotent stem cells (iPSCs)

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Development of chemically induced choroidal injury models for the study and treatment of AMD

Han I, Pandala N, Haefeli L, Lang MJ, Stone EM, Mullins RF, Tucker BA (2024) Development of chemically induced choroidal injury models for the study and treatment of AMD. ARVO Annual Meeting 65(7):5382. Objective: To describe the development of Age-Related Macular Degeneration (AMD) models through the targeted injury of choroidal cells in the eye. Summary:

Development of chemically induced choroidal injury models for the study and treatment of AMD Read More »

Unveiling cholera toxin binding and intoxication using enteroids and site-specific mutants

Boucher A (2024) Unveiling cholera toxin binding and intoxication using enteroids and site-specific mutants. Univ Gothenburg Thesis. Objective: To investigate the binding site requirements of cholera toxin in the human body. Summary: The cause of cholera symptoms is cholera toxin secreted by bacteria once in the small intestine. Cholera toxin has multiple binding sites that

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Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia

Matsuda T, Morigaki R, Hayasawa H, Koyama H, Oda T, Miyake K, Takagi Y (2024) Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia. Dis Model Mech 17(5):dmm050338. doi: 10.1242/dmm.050338 PMID: 38616770 Objective: To examine the influence of cerebellar abnormalities on the basal ganglia circuitry to investigate dystonia pathophysiology. Summary: Dystonia is

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Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Quiros-Ortega ME, Carretero-Rey M, Garcia-Garrido MF, López Téllez JF, Jiménez-Recuerda I, Muñoz de Leon López CA, Khan ZU (2024) Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit. CNS Neurosci Ther 30(4):e14727. doi:

Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit Read More »

A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861

Schulze FJ, Asadian-Birjand M, Pradela M, Niesler N, Nagal G, Fuchs H, (2024) A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861. BMC Biotechnol 24(1):24. doi: 10.1186/s12896-024-00854-5 PMID: 38685061 Objective: To examine whether the addition of the molecular adapter, that consists of a cell penetrating

A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861 Read More »

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