Author name: Kristen Hartman

A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861

Schulze FJ, Asadian-Birjand M, Pradela M, Niesler N, Nagal G, Fuchs H, (2024) A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861. BMC Biotechnol 24(1):24. doi: 10.1186/s12896-024-00854-5 PMID: 38685061 Objective: To examine whether the addition of the molecular adapter, that consists of a cell penetrating […]

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Cetuximab-toxin conjugate and npe6 with light enhanced cytotoxic effects in head and neck squamous cell carcinoma in vitro

Komatsu N, Kosai A, Kuroda M, Hamakubo T, Abe T (2024) Cetuximab-toxin conjugate and npe6 with light enhanced cytotoxic effects in head and neck squamous cell carcinoma in vitro. Biomedicines 12(5):973. doi: 10.3390/biomedicines12050973 PMID: 38790935 Objective: Combine the use of antibody-directed saporin and a photosensitizer to exert directed and improved cytotoxicity towards carcinoma cells as

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A pupillary contrast response in mice and humans: Neural mechanisms and visual functions

Fitzpatrick MJ, Krizan J, Hsiang JC, Shen N, Kerschensteiner D (2024) A pupillary contrast response in mice and humans: Neural mechanisms and visual functions. Neuron 112(14):2404-2422.e9. doi: 10.1016/j.neuron.2024.04.012 PMID: 38697114 Objective: To show that temporal contrast drives pupil constriction through a cell-type-specific retinal circuit in mice and humans. Summary: The pupillary contrast response enhances high

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Novel loading protocol combines highly efficient encapsulation of exogenous therapeutic toxin with preservation of extracellular vesicles properties, uptake and cargo activity

Zuppone S, Zarovni N, Noguchi K, Loria F, Morasso C, Lõhmus A, Nakase I, Vago R (2024) Novel loading protocol combines highly efficient encapsulation of exogenous therapeutic toxin with preservation of extracellular vesicles properties, uptake and cargo activity. Discov Nano 19(1):76. doi: 10.1186/s11671-024-04022-8 PMID: 38691254 Objective: Extracellular vesicles (EVs) have been investigated as carriers of

Novel loading protocol combines highly efficient encapsulation of exogenous therapeutic toxin with preservation of extracellular vesicles properties, uptake and cargo activity Read More »

A new Opn4cre recombinase mouse line to target intrinsically photosensitive retinal ganglion cells (ipRGCs)

Dyer B, Yu SO, Lane Brown R, Lang RA, D’Souza SP (2024) A new Opn4cre recombinase mouse line to target intrinsically photosensitive retinal ganglion cells (ipRGCs). bioRxiv 2024.04.16.589750. doi: 10.1101/2024.04.16.589750 PMID: 38659888 Objective: To generate a new Opn4cre knock-in allele [Opn4cre(DSO)], in which cre is placed immediately downstream of the Opn4 start codon. Summary: The

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Puberty-associated changes in Kiss1r, MC3R, and MC4R in the ewe

Thomson AC (2024) Puberty-associated changes in Kiss1r, MC3R, and MC4R in the ewe. West Virginia Univ Thesis. Objective: To examine kisspeptin receptor (Kiss1r) mRNA expression in gonadotropin releasing hormone (GnRH) neurons and melanocortin 3 and 4 receptor (MC3R/MC4R) expression in kisspeptin neurons across pubertal development. Summary: Kiss1r expression in GnRH neurons increased with development. In

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Advances and Challenges in Gene Therapy for Alzheimer’s Disease

Morroni F, Caccamo A (2024) Advances and Challenges in Gene Therapy for Alzheimer’s Disease. J Alzheimers Dis 101(s1):S417-S431. doi: 10.3233/JAD-230783 PMID: 39422937 Objective: Provide an overview of clinical and preclinical studies where gene therapy techniques have been utilized in the context of Alzheimer’s Disease (AD), highlighting their potential as novel therapeutic strategies. Summary: Gene therapy

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Cleavable peptide-triterpene conjugates for improved gene delivery

Kolster MK (2024) Cleavable peptide-triterpene conjugates for improved gene delivery. Univ Berlin Thesis. Objective: To use SO1861, a saponin triterpene, conjugated to a Saporin-encoding gene to target in vivo mice tumors. Summary: Targeted nanoplexes containing covalently conjugated SO1861 were prepared by incorporation of a targeting peptide and tested in vivo in an allograft tumor model

Cleavable peptide-triterpene conjugates for improved gene delivery Read More »

Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma

Chen S (2024) Nanocapsule-based prodrugs for targeted treatment of AIDS-associated non-hodgkin lymphoma. Univ California Thesis. Objective: To propose a novel nanocapsule based platform that encapsulates the native drugs using various monomers and crosslinkers through free radical polymerization. Summary: This encapsulation technology modifies the surface properties of the encapsulated drugs, enhancing their penetration into deeper tumor

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Estradiol’s role in timely puberty onset in the ewe 

Aerts EG (2024) Estradiol’s role in timely puberty onset in the ewe. Western Virginia Univ Thesis. Objective: To investigate the role of arcuate nucleus KNDy (kisspeptin/neurokinin B/dynorphin) neurons in regulating the timing of puberty onset and estradiol (E2) sensitivity in female sheep. Summary: Ablation of approximately 75% of KNDy neurons using NKB-SAP in the arcuate

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