Lewis R, Smith C, Nichols N (2024) Spinal TNF-α receptor expression in a rodent model of respiratory motor neuron death. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.1401
Objective: To create a model from respiratory deficit and study the role of inflammation in phrenic long-term facilitation.
Summary: Some neurodegenerative diseases are characterized by deficits in respiratory neurons, which can be modeled in rodents through the ablation of C4 TNFR1 expressing neurons. Phrenic long-term facilitation induced by acute intermittent hypoxia is observed in the model and at different times following the ablation to elucidate mechanisms of plasticity at different points of breathing deficits.
Usage: Intrapleural injection of CTB-SAP (25 ug, IT-14) in rats.
Related Products: CTB-SAP (Cat. #IT-14)