Author name: Kristen Hartman

Advances and Challenges in Gene Therapy for Alzheimer’s Disease

Morroni F, Caccamo A (2024) Advances and Challenges in Gene Therapy for Alzheimer’s Disease. J Alzheimers Dis 101(s1):S417-S431. doi: 10.3233/JAD-230783 PMID: 39422937 Objective: Provide an overview of clinical and preclinical studies where gene therapy techniques have been utilized in the context of Alzheimer’s Disease (AD), highlighting their potential as novel therapeutic strategies. Summary: Gene therapy […]

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Cancer Research

Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Screening targeting agents and their cell surface biomarkers for high

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An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory

Edwards CM, Guerrero IE, Thompson D, Dolezel T, Rinaman L (2024) An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory. bioRxiv 2024.04.09.588717. doi: 10.1101/2024.04.09.588717 PMID: 38645069 Objective: To investigate the role of a gut vagal afferent-to-central noradrenergic pathway in modulating the retrieval of conditioned passive avoidance memory in rats. Summary: This study

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Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models

Balukova A, Bokea K, Barber PR, Ameer-Beg SM, MacRobert AJ, Yaghini E (2024) Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models. Int J Mol Sci 25(8):4222. doi: 10.3390/ijms25084222 PMID: 38673807 Objective: To investigate the uptake and subcellular localization of TPPS2a and evaluate the photooxidative mechanism

Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models Read More »

Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia

Kumbhare D, Rajagopal M, Toms J, Freelin A, Weistroffer G, McComb N, Karnam S, Azghadi A, Murnane KS, Baron MS, Holloway KL (2024) Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia. bioRxiv 2024.04.05.588271. doi: 10.1101/2024.04.05.588271 PMID: 38645266 Objective: To assess the effects of varying stimulation patterns and duration

Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia Read More »

Targeted therapy for multiple myeloma: an overview on CD138-based strategies

Riccardi F, Tangredi C, Dal Bo M, Toffoli G (2024) Targeted therapy for multiple myeloma: an overview on CD138-based strategies. Front Oncol 14:1370854. doi: 10.3389/fonc.2024.1370854 PMID: 38655136 Objective: To provide an overview of the most important aspects of multiple myeloma (MM) disease and to investigate the molecular functions of CD138 in physiologic and malignant cell

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The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations

Jiao L, Kang H, Geng Y, Liu X, Wang M, Shu K (2024) The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations. Front Aging Neurosci 16:1376764. doi: 10.3389/fnagi.2024.1376764 PMID: 38650866 Objective: To review previous animal studies of NBM lesions, NBM-DBS models, and clinical

The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations Read More »

The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus

Wei J, Liu H, Zhou F, Zhang H, Zhang L (2024) The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus. Anesthesiology and Perioperative Science 2(17) doi: 10.1007/s44254-024-00051-9 Objective: To provide novel insights into the investigation of pain regulation within bidirectional regulatory pathway between the brain and cerebrospinal fluid, with

The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus Read More »

Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways

MacLean MR, Walker OL, Arun RP, Fernando W, Marcato P (2024) Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways. Int J Mol Sci 25(7):4102. doi: 10.3390/ijms25074102 PMID: 38612911 Objective: To provide a comprehensive overview of the therapeutic targets associated with cancer stem cells (CSCs) of solid tumors

Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways Read More »

Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding

Choi PP, Wang Q, Brenner LA, Li AJ, Ritter RC, Appleyard SM (2024) Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding. Endocrinology 165(5):bqae021. doi: 10.1210/endocr/bqae021 PMID: 38368624 Objective: To explore the role of NPY receptor-expressing neurons in regulating feeding behavior in rats. Summary: In response to glucose deficits, rats exhibit counter-regulatory

Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding Read More »

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