Author name: Kristen Hartman

Puberty-associated changes in Kiss1r, MC3R, and MC4R in the ewe

Thomson AC (2024) Puberty-associated changes in Kiss1r, MC3R, and MC4R in the ewe. West Virginia Univ Thesis. Objective: To examine kisspeptin receptor (Kiss1r) mRNA expression in gonadotropin releasing hormone (GnRH) neurons and melanocortin 3 and 4 receptor (MC3R/MC4R) expression in kisspeptin neurons across pubertal development. Summary: Kiss1r expression in GnRH neurons increased with development. In […]

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Cleavable peptide-triterpene conjugates for improved gene delivery

Kolster MK (2024) Cleavable peptide-triterpene conjugates for improved gene delivery. Univ Berlin Thesis. Objective: To use SO1861, a saponin triterpene, conjugated to a Saporin-encoding gene to target in vivo mice tumors. Summary: Targeted nanoplexes containing covalently conjugated SO1861 were prepared by incorporation of a targeting peptide and tested in vivo in an allograft tumor model

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Cancer Research

Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Screening targeting agents and their cell surface biomarkers for high

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An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory

Edwards CM, Guerrero IE, Thompson D, Dolezel T, Rinaman L (2024) An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory. bioRxiv 2024.04.09.588717. doi: 10.1101/2024.04.09.588717 PMID: 38645069 Objective: To investigate the role of a gut vagal afferent-to-central noradrenergic pathway in modulating the retrieval of conditioned passive avoidance memory in rats. Summary: This study

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Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models

Balukova A, Bokea K, Barber PR, Ameer-Beg SM, MacRobert AJ, Yaghini E (2024) Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models. Int J Mol Sci 25(8):4222. doi: 10.3390/ijms25084222 PMID: 38673807 Objective: To investigate the uptake and subcellular localization of TPPS2a and evaluate the photooxidative mechanism

Cellular imaging and time-domain FLIM studies of meso-tetraphenylporphine disulfonate as a photosensitising agent in 2D and 3D models Read More »

Targeted therapy for multiple myeloma: an overview on CD138-based strategies

Riccardi F, Tangredi C, Dal Bo M, Toffoli G (2024) Targeted therapy for multiple myeloma: an overview on CD138-based strategies. Front Oncol 14:1370854. doi: 10.3389/fonc.2024.1370854 PMID: 38655136 Objective: To provide an overview of the most important aspects of multiple myeloma (MM) disease and to investigate the molecular functions of CD138 in physiologic and malignant cell

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Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia

Kumbhare D, Rajagopal M, Toms J, Freelin A, Weistroffer G, McComb N, Karnam S, Azghadi A, Murnane KS, Baron MS, Holloway KL (2024) Deep brain stimulation of nucleus basalis of meynert improves learning in rat model of dementia. bioRxiv 2024.04.05.588271. doi: 10.1101/2024.04.05.588271 PMID: 38645266 Objective: To assess the effects of varying stimulation patterns and duration

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The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus

Wei J, Liu H, Zhou F, Zhang H, Zhang L (2024) The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus. Anesthesiology and Perioperative Science 2(17) doi: 10.1007/s44254-024-00051-9 Objective: To provide novel insights into the investigation of pain regulation within bidirectional regulatory pathway between the brain and cerebrospinal fluid, with

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The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations

Jiao L, Kang H, Geng Y, Liu X, Wang M, Shu K (2024) The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations. Front Aging Neurosci 16:1376764. doi: 10.3389/fnagi.2024.1376764 PMID: 38650866 Objective: To review previous animal studies of NBM lesions, NBM-DBS models, and clinical

The role of the nucleus basalis of meynert in neuromodulation therapy: A systematic review from the perspective of neural network oscillations Read More »

Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways

MacLean MR, Walker OL, Arun RP, Fernando W, Marcato P (2024) Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways. Int J Mol Sci 25(7):4102. doi: 10.3390/ijms25074102 PMID: 38612911 Objective: To provide a comprehensive overview of the therapeutic targets associated with cancer stem cells (CSCs) of solid tumors

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