Author name: Kristen Hartman

Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding

Choi PP, Wang Q, Brenner LA, Li AJ, Ritter RC, Appleyard SM (2024) Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding. Endocrinology 165(5):bqae021. doi: 10.1210/endocr/bqae021 PMID: 38368624 Objective: To explore the role of NPY receptor-expressing neurons in regulating feeding behavior in rats. Summary: In response to glucose deficits, rats exhibit counter-regulatory […]

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American Association for Cancer Research, AACR 2024

Events /

Visit ATS April 7-10, Booth 3453 to discover how ATS products can advance your Cancer Research Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of

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Antibody Drug Conjugates to Treat Cancer

Targeting Topics /

Antibody Drug Conjugates to Treat Cancer Antibody Screening for Cancer Research and Drug Development There is a growing need for therapeutics for cancer, autoimmune diseases, blood diseases and Alzheimer’s disease. Due to their ability to bind to a specific target antigen, monoclonal antibodies are increasingly being screened for therapeutic drug development. In May 2021, the

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Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits

Nord C, Jones I, Garcia-Maestre M, Hägglund AC, Carlsson L (2024) Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn 253(10):922-939. doi: 10.1002/dvdy.707 PMID: 38546215 Objective: To demonstrate that mTORC1 mediates critical roles during neuronal lamination using the mouse retina as a model system. Summary: This study establishes a critical role for

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Increased systemic levels of centrally acting b-type natriuretic peptide are associated with chronic itch of different types

Nattkemper LA, Kim BS, Yap QV, Hoon MA, Mishra SK, Yosipovitch G (2024) Increased systemic levels of centrally acting b-type natriuretic peptide are associated with chronic itch of different types. J Invest Dermatol S0022-202X(24)00197-0. doi: 10.1016/j.jid.2024.02.026 PMID: 38522572 Objective: Examines plasma BNP levels and N-terminal pro-BNP levels in patients with differing types of chronic itch

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Functions and mechanisms of adenosine and its receptors in sleep regulation

Huang L, Zhu W, Li N, Zhang B, Dai W, Li S, Xu H (2024) Functions and mechanisms of adenosine and its receptors in sleep regulation. Sleep Med 115:210-217. doi: 10.1016/j.sleep.2024.02.012 PMID: 38373361 Objective: To summarize the current research on the functions and possible mechanisms of adenosine and its receptors in regulating sleep and homeostatic

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The gut-brain axis and cognitive control: A role for the vagus nerve

Décarie-Spain L, Hayes AMR, Lauer LT, Kanoski SE (2024) The gut-brain axis and cognitive control: A role for the vagus nerve. Semin Cell Dev Biol 156:201-209. doi: 10.1016/j.semcdb.2023.02.004 PMID: 36803834 Objective: To review evidence from rodent and human studies on how gastrointestinal vagus nerve signaling influences higher-order neurocognitive processes such as anxiety, motivation, learning, and

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Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement

Moreno-Rodríguez M, Martínez-Gardeazabal J, Bengoetxea de Tena I, Llorente-Ovejero A, Lombardero L, González de San Román E, Giménez-Llort L, Manuel I, Rodríguez-Puertas R (2024) Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement. bioRxiv 2024.03.07.583670. doi: 10.1101/2024.03.07.583670 Objective: Investigate the neuroprotective effect of treatment with the CB1 cannabinoid agonist, WIN55,212-2, against cholinergic degeneration. Summary: The endocannabinoid

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