Dyer B, Yu SO, Lane Brown R, Lang RA, D’Souza SP (2024) A new Opn4cre recombinase mouse line to target intrinsically photosensitive retinal ganglion cells (ipRGCs). bioRxiv doi: 10.1101/2024.04.16.589750
Objective: To generate a new Opn4cre knock-in allele [Opn4cre(DSO)], in which cre is placed immediately downstream of the Opn4 start codon.
Summary: The Opn4cre(DSO) mouse line improves the specificity of ipRGC labeling, enabling the targeted study of these cells in relation to light-regulated behaviors and physiology.
Usage: Histology and immunofluorescence.
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