Melanopsin Rabbit Polyclonal, affinity-purified [AB-N39]


SKU: AB-N39 Category: Quantity: 50 ug | Antibody Type: affinity-purified, Polyclonal | Host: rabbit | Reactivity: mouse | Conjugate: unconjugated | Usage: immunofluorescence, staining |

Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain melanopsin. The ipRGCs, with their amazing long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Affinity-purified Anti-Melanopsin (UF008) has very high specificity to mouse ipRGCs.

Affinity-purified anti-Melanopsin (UF008) was raised against the 15 N-terminal extracellular amino acids of mouse melanopsin. This antibody does not cross-react with melanopsins of other species, it is very specific for mouse.

Applications include immunofluorescence (1 µg/ml) and targeting (targeting agent in Melanopsin-SAP, Cat. #IT-44). This antibody works in both cross-section and flat-mount staining.

Anti-Melanopsin staining on either flat-mount or cross-section staining of mouse retina. Staining of the antibody is shown in green. Blue is DAPI and tdTomato (red) signal from OPN4cre; R26Syp-tdT mouse line. Cat. #AB-N38 (neat sera) is lot #205-130 and Cat. #AB-N39 (affinity-purified) is lot #205-129.
Images supplied courtesy of Wenjin Xu, Xiarong Lu, and Ignacio Provencio at the University of Virginia.
2-photon confocal microscope image from a single z-series using AB-N39 in flat-mount mouse retina at 1:4000and an AlexaFluor-568 secondary antibody.  This image is a single optic plane through the ganglion cell layer that also shows some proximal RGC dendrites.
Image courtesy of Matthew Van Hook, Ph.D.

keywords: Melanopsin, Intrinsically photosensitive retinal ganglion cells, ipRGC, ipRGCs, UF008, Anti-Melanopsin, Anti-UF008


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Melanopsin Products:

Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

Melanopsin Rabbit Polyclonal, affinity purified (Cat. #AB-N39)

Melanopsin-SAP (Cat. #IT-44)

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