Melanopsin Rabbit Polyclonal, affinity-purified [AB-N39]


SKU: AB-N39 Category: Antibody Type: affinity-purified, Polyclonal | Host: Rabbit | Reactivity: Mouse | Conjugate: unconjugated | Usage: immunocytochemistry, staining, targeting agent |

Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain melanopsin. The ipRGCs, with their amazing long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Affinity-purified Anti-Melanopsin (UF008) has very high specificity to mouse ipRGCs.

Affinity-purified anti-Melanopsin (UF008) was raised against the 15 N-terminal extracellular amino acids of mouse melanopsin. This antibody does not cross-react with melanopsins of other species, it is very specific for mouse.

2-photon confocal microscope image from a single z-series using AB-N39 in flat-mount mouse retina at 1:4000and an AlexaFluor-568 secondary antibody.  This image is a single optic plane through the ganglion cell layer that also shows some proximal RGC dendrites.
Image courtesy of Matthew Van Hook, Ph.D.

Applications include immunofluorescence (1 µg/ml) and targeting (targeting agent in Melanopsin-SAP, Cat. #IT-44). This antibody works in both cross-section and flat-mount staining.

Other Melanopsin Products:

Melanopsin Rabbit Polyclonal (Cat. #AB-N38) | Melanopsin Rabbit Polyclonal, affinity purified (Cat. #AB-N39) | Melanopsin-SAP (Cat. #IT-44)