Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain melanopsin. The ipRGCs, with their amazing long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Anti-Melanopsin (UF006) has very high specificity to mouse ipRGCs.
Anti-Melanopsin (UF006) recognizes a sequence representing the 15 most N-terminal amino acids of the mouse melanopsin extracellular domain. Anti-Melanopsin (UF006) does not cross-react with melanopsins of other species, it is very specific for mouse. This antibody is routinely tested by immunofluorescence.
Applications include immunofluorescence. This antibody does NOT work in immunoblotting.
Anti-Melanopsin staining on either flat-mount or cross-section staining of mouse retina. Staining of the antibody is shown in green. Blue is DAPI and tdTomato (red) signal from OPN4cre; R26Syp-tdT mouse line. Cat. #AB-N38 (neat sera) is lot #205-130 and Cat. #AB-N39 (affinity-purified) is lot #205-129.
Images supplied courtesy of Wenjin Xu, Xiarong Lu, and Ignacio Provencio at the University of Virginia.
keywords: melanopsin, Intrinsically photosensitive retinal ganglion cells, ipRGC, ipRGCs, UF006, Anti-Melanopsin, Anti-UF006, brain, neuroscience, circadian rhythm
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