Kolster MK (2024) Cleavable peptide-triterpene conjugates for improved gene delivery. Univ Berlin Thesis.
Objective: To use SO1861, a saponin triterpene, conjugated to a Saporin-encoding gene to target in vivo mice tumors.
Summary: Targeted nanoplexes containing covalently conjugated SO1861 were prepared by incorporation of a targeting peptide and tested in vivo in an allograft tumor model in mice. Using a suicide gene vector encoding the cytotoxic protein saporin, treatment with targeted SO1861-containing nanoplexes was observed to slow tumor growth and improve survival compared to vehicle control.
Usage: Saporin-nanocomplexes were intravaneuously injected into mice to determine transfection efficiency.
Related Products: Saporin (Cat. #PR-01)